Results 1 to 10 of about 119,022 (190)

Papel de la inflamación y la adhesión leucocitaria en la fisiopatología del daño orgánico en la hipertensión arterial. [PDF]

, 2010
La hipertensión arterial aumenta el estrés oxidativo, el cual a su vez impide una adecuada función endotelial. La disfunción endotelial es común en los pacientes hipertensos; se asocia con inflamación, incremento de algunos mediadores de la inflamación y
Castro Serna, David, Lozano Nuevo, José Juan, Rodríguez López, Leticia, Rubio Guerra, Alberto Francisco, Vargas Ayala, Germán   +4 more
core   +1 more source

A Journey into the Clinical Relevance of Heme Oxygenase 1 for Human Inflammatory Disease and Viral Clearance: Why Does It Matter on the COVID-19 Scene?

Antioxidants, 2022
Heme oxygenase 1 (HO-1), the rate-limiting enzyme in heme degradation, is involved in the maintenance of cellular homeostasis, exerting a cytoprotective role by its antioxidative and anti-inflammatory functions.
Ayelen Toro, María Sol Ruiz, Sofia Lage-Vickers, Pablo Sanchis, Agustina Sabater, Gaston Pascual, Rocio Seniuk, Florencia Cascardo, Sabrina Ledesma-Bazan, Felipe Vilicich, Elba Vazquez, Geraldine Gueron   +11 more
doaj   +1 more source

Targeting macrophage migration inhibitory factor (MIF): a promising therapy for inflammatory ocular diseases

Journal of Ophthalmic Inflammation and Infection, 2023
Inflammatory ocular diseases are characterized by the presence of a persistent inflammatory response which cause tissue injury, decrease visual acuity and in severe cases, blindness.
Alicia Vázquez, Marisol I. González, José L. Reyes   +2 more
doaj   +1 more source

Techniques to Study Inflammasome Activation and Inhibition by Small Molecules

Molecules, 2021
Inflammasomes are immune cytosolic oligomers involved in the initiation and progression of multiple pathologies and diseases. The tight regulation of these immune sensors is necessary to control an optimal inflammatory response and recover organism ...
Diego Angosto-Bazarra, Cristina Molina-López, Alejandro Peñín-Franch, Laura Hurtado-Navarro, Pablo Pelegrín   +4 more
doaj   +1 more source

Evolutionary analyses of the gasdermin family suggest conserved roles in infection response despite loss of pore-forming functionality

BMC Biology, 2022
Background Gasdermins are ancient (>500million-years-ago) proteins, constituting a family of pore-forming proteins that allow the release of intracellular content including proinflammatory cytokines.
Diego Angosto-Bazarra, Cristina Alarcón-Vila, Laura Hurtado-Navarro, María C. Baños, Jack Rivers-Auty, Pablo Pelegrín   +5 more
doaj   +1 more source

Physiological and pathophysiological functions of NLRP6: pro- and anti-inflammatory roles

Communications Biology, 2022
This review discusses emerging roles for the NLR family pyrin domain containing 6 receptor (NLRP6) in intestinal homeostasis, inflammation, cancer, the nervous system and liver disease.
Diego Angosto-Bazarra, Cristina Molina-López, Pablo Pelegrín   +2 more
doaj   +1 more source

Altered insulin secretion dynamics relate to oxidative stress and inflammasome activation in children with obesity and insulin resistance

Journal of Translational Medicine, 2023
Background Insulin resistance (IR) is considered the main driver of obesity related metabolic complications, and is related to oxidative stress and inflammation, which in turn promote each other.
Álvaro González-Domínguez, Thalía Belmonte, Jesús Domínguez-Riscart, Pablo Ruiz-Ocaña, Inés Muela-Zarzuela, Ana Saez-Benito, Raúl Montañez-Martínez, Rosa M. Mateos, Alfonso M. Lechuga-Sancho   +8 more
doaj   +1 more source

Pin-Pointing the Key Hubs in the IFN-γ Pathway Responding to SARS-CoV-2 Infection

Viruses, 2022
Interferon gamma (IFN-γ) may be potential adjuvant immunotherapy for COVID-19 patients. In this work, we assessed gene expression profiles associated with the IFN-γ pathway in response to SARS-CoV-2 infection. Employing a case-control study from SARS-CoV-
Ayelen Toro, Sofia Lage-Vickers, Juan Bizzotto, Felipe Vilicich, Agustina Sabater, Gaston Pascual, Sabrina Ledesma-Bazan, Pablo Sanchis, Maria Sol Ruiz, Ana Paula Arevalo, Jorge L. Porfido, Mercedes Abbate, Rocio Seniuk, Estefania Labanca, Nicolas Anselmino, Nora M. Navone, Daniel F. Alonso, Elba Vazquez, Martina Crispo, Javier Cotignola, Geraldine Gueron   +20 more
doaj   +1 more source

CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis

eLife, 2020
P2X7 receptor activation induces the release of different cellular proteins, such as CD14, a glycosylphosphatidylinositol (GPI)-anchored protein to the plasma membrane important for LPS signaling via TLR4.
Cristina Alarcón-Vila, Alberto Baroja-Mazo, Carlos de Torre-Minguela, Carlos M Martínez, Juan J Martínez-García, Helios Martínez-Banaclocha, Carlos García-Palenciano, Pablo Pelegrin   +7 more
doaj   +1 more source

Exploiting Interdata Relationships in Prostate Cancer Proteomes: Clinical Significance of HO-1 Interactors

Antioxidants, 2022
Prostate cancer (PCa) cells display abnormal expression of proteins resulting in an augmented capacity to resist chemotherapy and colonize distant organs. We have previously shown the anti-tumoral role of heme oxygenase 1 (HO-1) in this disease.
Sofia Lage-Vickers, Pablo Sanchis, Juan Bizzotto, Ayelen Toro, Agustina Sabater, Rosario Lavignolle, Nicolas Anselmino, Estefania Labanca, Alejandra Paez, Nora Navone, Maria P. Valacco, Javier Cotignola, Elba Vazquez, Geraldine Gueron   +13 more
doaj   +1 more source