Results 1 to 10 of about 3,477 (115)
Antioxidants, 2022 Heme oxygenase 1 (HO-1), the rate-limiting enzyme in heme degradation, is involved in the maintenance of cellular homeostasis, exerting a cytoprotective role by its antioxidative and anti-inflammatory functions.
Ayelen Toro +11 more
doaj +1 more source
Journal of Ophthalmic Inflammation and Infection, 2023 Inflammatory ocular diseases are characterized by the presence of a persistent inflammatory response which cause tissue injury, decrease visual acuity and in severe cases, blindness.
Alicia Vázquez +2 more
doaj +1 more source
Techniques to Study Inflammasome Activation and Inhibition by Small Molecules
Molecules, 2021 Inflammasomes are immune cytosolic oligomers involved in the initiation and progression of multiple pathologies and diseases. The tight regulation of these immune sensors is necessary to control an optimal inflammatory response and recover organism ...
Diego Angosto-Bazarra +4 more
doaj +1 more source
BMC Biology, 2022 Background Gasdermins are ancient (>500million-years-ago) proteins, constituting a family of pore-forming proteins that allow the release of intracellular content including proinflammatory cytokines.
Diego Angosto-Bazarra +5 more
doaj +1 more source
Physiological and pathophysiological functions of NLRP6: pro- and anti-inflammatory roles
Communications Biology, 2022 This review discusses emerging roles for the NLR family pyrin domain containing 6 receptor (NLRP6) in intestinal homeostasis, inflammation, cancer, the nervous system and liver disease.
Diego Angosto-Bazarra +2 more
doaj +1 more source
Journal of Translational Medicine, 2023 Background Insulin resistance (IR) is considered the main driver of obesity related metabolic complications, and is related to oxidative stress and inflammation, which in turn promote each other.
Álvaro González-Domínguez +8 more
doaj +1 more source
Pin-Pointing the Key Hubs in the IFN-γ Pathway Responding to SARS-CoV-2 Infection
Viruses, 2022 Interferon gamma (IFN-γ) may be potential adjuvant immunotherapy for COVID-19 patients. In this work, we assessed gene expression profiles associated with the IFN-γ pathway in response to SARS-CoV-2 infection. Employing a case-control study from SARS-CoV-
Ayelen Toro +20 more
doaj +1 more source
Veterinary Dermatology, Volume 34, Issue 5, Page 425-440, October 2023., 2023 Background – While the clinical features were described recently, the histopathological characterisation of trunk‐dominant canine pemphigus foliaceus (PF) is lacking, and whether it differs from classic facial or insecticide‐triggered PF is unknown. Hypothesis/Objectives – This study describes the histopathological findings of trunk‐dominant PF, and ...
Natalie Katharina Yvonne Gedon +6 more
wiley +1 more source
CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis
eLife, 2020 P2X7 receptor activation induces the release of different cellular proteins, such as CD14, a glycosylphosphatidylinositol (GPI)-anchored protein to the plasma membrane important for LPS signaling via TLR4.
Cristina Alarcón-Vila +7 more
doaj +1 more source
GSK3β Inhibition Prevents Macrophage Reprogramming by High-Dose Methotrexate
Journal of Innate Immunity, 2022 Methotrexate (MTX) is an antifolate drug used as a chemotherapeutic agent for acute lymphoblastic leukemia, where MTX improves patients’ prognosis. Macrophage reprogramming is being increasingly assessed as an antitumor therapeutic strategy. However, and
Israel Ríos +9 more
doaj +1 more source