Results 21 to 30 of about 127,695 (239)
GSK3β Inhibition Prevents Macrophage Reprogramming by High-Dose Methotrexate
Journal of Innate Immunity, 2022 Methotrexate (MTX) is an antifolate drug used as a chemotherapeutic agent for acute lymphoblastic leukemia, where MTX improves patients’ prognosis. Macrophage reprogramming is being increasingly assessed as an antitumor therapeutic strategy. However, and
Israel Ríos +9 more
doaj +1 more source
Veterinary Dermatology, Volume 34, Issue 4, Page 327-338, August 2023., 2023 Background – The caninised monoclonal antibody lokivetmab (LKV), directed at interleukin (IL)‐31, is very effective at controlling pruritus in most dogs with atopic dermatitis (AD). However, evidence exists that IL‐31 is not required for the induction of acute allergic skin inflammation, which might explain why this treatment is less efficacious in ...
Chie Tamamoto‐Mochizuki +4 more
wiley +1 more source
Conditioned serum in vitro treatment of chondrocyte pellets and osteoarthritic explants
Equine Veterinary Journal, Volume 55, Issue 2, Page 325-335, March 2023., 2023 Abstract Background Autologous conditioned serum (ACS) is used to treat osteoarthritis in horses, although its effects are not fully investigated. Objectives To investigate the effects of equine serum and conditioned serum on chondrocytes stimulated with interleukin (IL)‐1β and cartilage explants with mild osteoarthritis.
Maria Löfgren +8 more
wiley +1 more source
The expression of YWHAZ and NDRG1 predicts aggressive outcome in human prostate cancer
Communications Biology, 2021 Using integrative tissue-omics, Lage-Vickers, Bizzotto et al. classify prostate cancer patients into high YWHAZ and NDRG1 expression subgroups that correlate with a high and intermediate risk of disease progression.
Sofia Lage-Vickers +12 more
doaj +1 more source
Frontiers in Immunology, 2021 Background and AimsGM-CSF-dependent macrophage polarization has been demonstrated in rheumatoid arthritis (RA). Our aim was to seek diagnostic/prognostic biomarkers for undifferentiated arthritis (UA) by analyzing GM-CSF expression and source, macrophage
Sara Fuentelsaz-Romero +9 more
doaj +1 more source
Biomolecules, 2020 The inflammatory tumor microenvironment is a fertile niche accelerating prostate cancer (PCa). We have reported that heme-oxygenase (HO-1) had a strong anti-tumoral effect in PCa.
Emiliano Ortiz +8 more
doaj +1 more source
Mast Cells in Immune-Mediated Cholangitis and Cholangiocarcinoma
Cells, 2022 Cholestasis, which is impaired bile flow from the liver into the intestine, can be caused by cholangitis and/or bile duct obstruction. Cholangitis can arise from bacterial infections and cholelithiasis, however, immune-mediated cholangitis in primary ...
Marisol I. González +4 more
doaj +1 more source
Onset and duration of action of lokivetmab in a canine model of IL‐31 induced pruritus
Veterinary Dermatology, Volume 32, Issue 6, Page 681-e182, December 2021., 2021 Onset of antipruritic action of lokivetmab in dogs. Laboratory‐bred beagle dogs were dosed subcutaneously with either placebo or lokivetmab at 2.0 mg/kg on Day (D) 0. Approximately 2.5 h post‐dosing, pruritus was induced using canine interleukin (IL)‐31. Animals were observed for pruritic behaviours for a total of 2 h (3–5 h post‐treatment with placebo
Timothy J. Fleck +6 more
wiley +1 more source
Inflamación granulomatosa peneana por inyección de sustancia extraña
Revista Mexicana de Urología, 2019 La silicona líquida se ha usado desde hace varias décadas como material médico. En urología, se ha utilizado para el engrosamiento peneano, inyectándose en el tejido celular subcutáneo, lo que puede producir una reacción inflamatoria granulomatosa con ...
Garazi Gutiérrez Zurimendi +7 more
openalex +3 more sources
Veterinary Dermatology, Volume 32, Issue 4, Page 331-e92, August 2021., 2021 Background MicroRNAs (miRNA) are short, single‐stranded RNA molecules that regulate gene expression in a post‐transcriptional manner. Their expression is proposed to be tissue‐specific and alterations in miRNA expression have been detected in many diseases. Objective To compare miRNA expression in the skin of healthy Labrador and golden retrievers, and
Marie Isabel Morlang +3 more
wiley +1 more source