Results 121 to 130 of about 4,367,929 (381)

Interferon α2 and interferon γ induce the degranulation independent production of VEGF‐A and IL‐1 receptor antagonist and other mediators from human mast cells

open access: yesImmunity, Inflammation and Disease, 2018
Background Mast cells are resident immune effector cells, often studied in the context of allergic disease. Found in substantial numbers at sites of potential infection they are increased at sites of angiogenesis and can be pivotal for the sensing and ...
Sharon A. Oldford   +6 more
doaj   +1 more source

Sex-specific roles of cellular inflammation and cardiometabolism in obesity-associated depressive symptomatology. [PDF]

open access: yes, 2019
BackgroundObesity and depression are complex conditions with stronger comorbid relationships among women than men. Inflammation and cardiometabolic dysfunction are likely mechanistic candidates for increased depression risk, and their prevalence differs ...
Cabrera, Yesenia   +6 more
core   +1 more source

Sleep and inflammation in resilient aging. [PDF]

open access: yes, 2014
Sleep quality is important to health, and increasingly viewed as critical in promoting successful, resilient aging. In this review, the interplay between sleep and mental and physical health is considered with a focus on the role of inflammation as a ...
Irwin, Michael R
core   +1 more source

Inflammation and Incretins

open access: yesIndian Journal of Endocrinology and Metabolism, 2012
Nutrient excess results in systemic inflammation in diabetes contributing to insulin resistance, dyslipidaemia and increased cardiovascular risk. GLP-1 agonists and DPP-4 inhibitors, which are now well accepted therapies for diabetes may play a unique role in modulating this inflammatory process.
openaire   +4 more sources

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

Need for standardization of Influenza A virus-induced cell death in vivo to improve consistency of inter-laboratory research findings

open access: yesCell Death Discovery
The involvement of necroptosis in the control of influenza A virus (IAV) infection has been reported in multiple studies. Downstream of the nucleic acid sensor ZBP1, RIPK3 kinase activity is critically involved in the induction of necroptotic cell death ...
Teodora Oltean   +3 more
doaj   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

open access: yesFEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha

open access: yesNature Communications, 2018
Invariant natural killer T (iNKT) cells rapidly enhance cytokine secretion and effector function following activation, but the underlying mechanism is still unclear.
Srinath Govindarajan   +13 more
doaj   +1 more source

Pelvic Inflammation* [PDF]

open access: yesBJOG: An International Journal of Obstetrics & Gynaecology, 1914
n ...
openaire   +3 more sources

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