Results 121 to 130 of about 4,758,008 (341)

Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis

Nature Communications, 2019
Maintaining the intestinal barrier function requires a balance of multiple signalling pathways. Here the authors show that A20, an anti-inflammatory and anti-apoptotic protein, and Atg1611, an autophagy regulator, cross-regulate their respective protein ...
Karolina Slowicka, Inmaculada Serramito-Gómez, Emilio Boada-Romero, Arne Martens, Mozes Sze, Ioanna Petta, Hanna K. Vikkula, Riet De Rycke, Eef Parthoens, Saskia Lippens, Savvas N. Savvides, Andy Wullaert, Lars Vereecke, Felipe X. Pimentel-Muiños, Geert van Loo   +14 more
doaj   +1 more source

Muscle Specific miRNAs are induced by testosterone and independently upregulated by age.

Frontiers in Physiology, 2014
Age dependent decline in skeletal muscle function leads to impaired metabolic flexibility in elderly individuals. Physical activity and testosterone treatment have proven efficient strategies for delaying this condition.
Søren eNielsen, Thine eHvid, Meghan eKelly, Birgitte eLindegaard, Christine eDethlefsen, Kamilla eWinding, Neha eMathur, Camilla eScheele, Bente Klarlund Pedersen, Matthew J. Laye, Matthew J. Laye   +10 more
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Challenging the conventional wisdom: Re‐evaluating Smpd3's role in extracellular vesicle biogenesis

Journal of Extracellular Biology
Extracellular vesicles (EVs) are pivotal in intercellular communication, impacting diverse physiological and pathological processes. Current in vitro EV biogenesis studies often utilize pharmacological inhibitors, inducing off‐target effects and ...
Marlies Burgelman, Pieter Dujardin, Anthony Willems, Tino Hochepied, Griet Van Imschoot, Elien Van Wonterghem, Lien Van Hoecke, Charysse Vandendriessche, Roosmarijn E. Vandenbroucke   +8 more
doaj   +1 more source

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Retracted: Neuropilin-1highCD4+CD25+ Regulatory T Cells Exhibit Primary Negative Immunoregulation in Sepsis

Mediators of Inflammation, 2020
Mediators of Inflammation
doaj   +1 more source

Expression of Concern on “IκB Kinase Inhibitor VII Modulates Sepsis-Induced Excessive Inflammation and Cardiac Dysfunction in 5/6 Nephrectomized Mice”

Mediators of Inflammation, 2023
Mediators of Inflammation
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Effects of turmeric extract supplementation on inflammation and muscle damage after a half-marathon race: a randomized, double-blind, placebo-controlled trial

, 2020
Flávia Rasmussen Faria, Aline Corado Gomes, Alisson Henrique Antunes, Kênnia Rocha Rezende, Gustavo D. Pimentel, Camila Lemos Pinto Oliveira, Barbara Moura Antunes, Fábio Santos Lira, Marcelo Saldanha Aoki, João Felipe Mota   +9 more
openalex   +2 more sources

Sex Differences in the Effect of Inflammation on Subjective Social Status: A Randomized Controlled Trial of Endotoxin in Healthy Young Adults. [PDF]

, 2019
It has been established that inflammation leads to a variety of changes in social experience, but one area of social experience that has been overlooked is subjective social status.
Breen, Elizabeth C, Eisenberger, Naomi I, Irwin, Michael R, Jevtic, Ivana, Moieni, Mona, Muscatell, Keely A   +5 more
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