Results 41 to 50 of about 2,834,842 (317)
Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas
Pediatric Blood &Cancer, EarlyView.ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall +2 more
wiley +1 more source
Solobacterium moorei promotes the progression of adenomatous polyps by causing inflammation and disrupting the intestinal barrier [PDF]
Background Adenomatous polyps (APs) with inflammation are risk factors for colorectal cancer. However, the role of inflammation-related gut microbiota in promoting the progression of APs is unknown.
Zhang, Qi +15 more
core +2 more sources
Adhesion molecule-dependent mechanisms regulate the rate of macrophage clearance during the resolution of peritoneal inflammation [PDF]
, 2002 Macrophage clearance is essential for the resolution of inflammation. Much is known about how monocytes enter the inflammatory site but little is known about how resultant macrophages are cleared. We have previously demonstrated that macrophage clearance
Mutsaers, SE +17 more
core +1 more source
Health Literacy, Self‐Efficacy and Knowledge of Sickle Cell Disease Among Caregivers
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Sickle cell disease (SCD) is a hereditary blood disorder in which abnormal haemoglobin leads to severe anaemia, painful crises and organ failure. Caregivers’ health literacy (HL) – their ability to assess, understand and apply information, and interact with healthcare professionals – is crucial for managing children with SCD, yet ...
Melanie Bruinooge +6 more
wiley +1 more source
Mediators of Inflammation, 2015 Cachexia is a complex wasting syndrome associated with a marked detrimental effect upon life quality and survival in patients with cancer, chronic obstructive pulmonary disease (COPD), chronic heart failure, AIDS, and chronic kidney disease, among other conditions. Its prevalence is of around 5 to 15% in cardiac patients at end stage, rising up to 30%,
Seelaender M. +5 more
openaire +5 more sources
Autophagy and inflammation [PDF]
Clinical and Translational Medicine, 2017 AbstractAutophagy is a homeostatic mechanism involved in the disposal of damaged organelles, denatured proteins as well as invaded pathogens through a lysosomal degradation pathway. Recently, increasing evidences have demonstrated its role in both innate and adaptive immunity, and thereby influence the pathogenesis of inflammatory diseases.
Mengjia Qian +2 more
openaire +3 more sources
Nitric oxide in acute and chronic inflammation. [PDF]
, 2002 PhDNitric oxide (NO) is a signalling molecule formed when L-arginine is converted to L-citrulline by the enzyme NO synthase (NOS. NOS exists as three isoforms, ecNOS is constitutively expressed in endothelial cells and nNOS in neuronal cells, while a ...
Paul-Clark, Mark John
core
Early Impact of Childhood Opportunity on Neurocognitive Outcomes in Sickle Cell Disease
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction Neurocognitive impairment is a well‐recognized complication of sickle cell disease (SCD) that begins early in childhood and persists across development. While cerebrovascular injury contributes substantially to risk, neurocognitive deficits are also observed in children without overt or silent cerebral infarctions, suggesting ...
Julia E. LaMotte +5 more
wiley +1 more source
Biochemia Medica, 2012 Inflammation and haemostasis are interrelated pathophysiologic processes that considerably affect each other. In this bidirectional relationship, inflammation leads to activation of the haemostatic system that in turn also considerably influences inflammatory activity.
openaire +5 more sources