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Mediators of Inflammation in Pulmonary Diseases [PDF]

open access: yesMediators of Inflammation, 2015
Inflammation is supposed to play a great role in the pathogenesis of the most common diseases of the respiratory system. In Chronic Obstructive Pulmonary Disease (COPD), which is a major cause of morbidity and mortality all around the world, smoking mainly causes the initiation of the inflammatory process that leads to an impaired respiratory function.
Kostas Spiropoulos   +4 more
doaj   +4 more sources

Serum T2-High Inflammation Mediators in Eosinophilic COPD [PDF]

open access: yesBiomolecules
Eosinophils are central inflammatory cells in asthma; however, a portion of patients with chronic obstructive pulmonary disease (COPD) have blood or sputum eosinophilia, a condition termed eosinophilic COPD (eCOPD), which may contribute to the ...
Andrius Januskevicius   +5 more
doaj   +2 more sources

Combined In Silico, In Vivo, and In Vitro Studies Shed Insights into the Acute Inflammatory Response in Middle-Aged Mice [PDF]

open access: yes, 2013
We combined in silico, in vivo, and in vitro studies to gain insights into age-dependent changes in acute inflammation in response to bacterial endotoxin (LPS). Time-course cytokine, chemokine, and NO2-/NO3- data from "middle-aged" (6-8 months old) C57BL/
A Torres   +63 more
core   +28 more sources

Mediators of inflammation [PDF]

open access: yesCurrent Opinion in Immunology, 1997
Therapeutic studies and genetically engineered animals have elucidated the inflammatory roles of cytokines and chemokines in autoimmune disease. Most unexpected has been a continuum of recent evidence demonstrating that inflammatory mediators are crucial in lymphoid organ development, thus suggesting that these hitherto unrelated processes have common ...
R, Sacca, C A, Cuff, N H, Ruddle
openaire   +3 more sources

Prosaposin mediates inflammation in atherosclerosis [PDF]

open access: yesScience Translational Medicine, 2021
Prosaposin mediates inflammation in experimental and human atherosclerosis and is associated with cellular metabolism and mTOR signaling.
van Leent, Mandy M. T.   +32 more
openaire   +4 more sources

Porphyromonas gingivalis periodontal infection and its putative links with Alzheimer’s disease [PDF]

open access: yes, 2015
Periodontal disease (PD) and Alzheimer’s disease (AD) are inflammatory conditions affecting the global adult population. In the pathogenesis of PD, subgingival complex bacterial biofilm induces inflammation that leads to connective tissue degradation and
Crean, Stjohn   +4 more
core   +12 more sources

Lipid Mediators in Inflammation [PDF]

open access: yesMicrobiology Spectrum, 2016
ABSTRACTLipids are potent signaling molecules that regulate a multitude of cellular responses, including cell growth and death and inflammation/infection, via receptor-mediated pathways. Derived from polyunsaturated fatty acids (PUFAs), such as arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), each lipid displays ...
Bennett, M, Gilroy, DW
openaire   +3 more sources

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