Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
The systemic-level repercussions of cancer-associated inflammation mediators produced in the tumor microenvironment. [PDF]
Front Endocrinol (Lausanne), 2022 Aguilar-Cazares D +7 more
europepmc +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Inflammatory mediators of neuropathic pain
Revista DorBACKGROUND AND OBJECTIVES: Pro-inflammatory chemical mediators and algogenic substances seem to be confused by the sharing of their actions and by interactions in painful and inflammatory presentation.
José Oswaldo de Oliveira Júnior +2 more
doaj +1 more source
In Vitro Induction of Eryptosis by Uremic Toxins and Inflammation Mediators in Healthy Red Blood Cells. [PDF]
J Clin Med, 2022 Virzì GM +6 more
europepmc +1 more source
MO047MEGALIN/CUBILIN-LYSOSOME-MEDIATED ALBUMIN REABSORPTION IS INVOLVED IN THE TUBULAR CELL ACTIVATION OF NLRP3 INFLAMMASOME AND TUBULOINTERSTITIAL INFLAMMATION [PDF]
, 2016 Dan Liu, Bi‐Cheng Liu
openalex +1 more source
Cure of chronic viral infection and virus-induced type 1 diabetes by neutralizing antibodies [PDF]
, 2009 The use of neutralizing antibodies is one of the most successful methods to interfere with receptor–ligand interactions in vivo. In particular blockade of soluble inflammatory mediators or their corresponding cellular receptors was proven an effective ...
Christen, Urs +2 more
core
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Accelerated brain aging with opioid misuse and HIV: New insights on the role of glially derived pro-inflammation mediators and neuronal chloride homeostasis. [PDF]
Curr Opin Neurobiol, 2023 Hauser KF, Ohene-Nyako M, Knapp PE.
europepmc +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source