Results 161 to 170 of about 362,551 (290)

Synergistic effect of IL-12 and IL-18 in driving intestinal Th1-mediated inflammation in Crohn's disease

, 2000
Akira Okazawa, Takanori Kanai∥, Mamoru Watanabe, Toshiro Sate, Nagamu Inoue, Hiromasa Ishii, Masao Ikeda, Masashi Kurimoto, Toshifumi Hibi∥   +8 more
openalex   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Skin Inflammation During Contact Hypersensitivity Is Mediated by Early Recruitment of CD8+ T Cytotoxic 1 Cells Inducing Keratinocyte Apoptosis [PDF]

, 2002
Hitoshi Akiba, Jeanne Kehren, Marie-Thérèse Ducluzeau, Maya Krasteva, Françoise Horand, Dominique Kaiserlian, Fumio Kaneko, Jean‐François Nicolas   +7 more
openalex   +1 more source

SensRORing cholesterol to drive protumoral myelopoiesis

Molecular Oncology, EarlyView.
Bleve et al. uncover a cholesterol‐driven immune evasion pathway, where RORγ‐dependent myelopoiesis shapes tumor immunosuppression. Targeting RORγ and PCSK9 emerges as a strategy to boost cancer immunotherapy. Protumoral myelopoiesis is a determinant of immunoevasion and tumor spread in many malignancies.
Sara Gennari, Luigi Nezi, Teresa Manzo
wiley   +1 more source

Regulatory effect of inflammatory mediators in spinal cord injury. [PDF]

Front Immunol
Zeng WC, Zeng FJ.
europepmc   +1 more source

Macrophage-derived IL-18–mediated intestinal inflammation in the murine model of Crohn's disease

, 2001
Takanori Kanai∥, Mamoru Watanabe, Akira Okazawa, Toshiro Sato, Motomi Yamazaki, Susumu Okamoto, Hiromasa Ishii, Teruji Totsuka, Ryoichi Iiyama, Ryuichi Okamoto, Masao Ikeda, Masashi Kurimoto, Kiyoshi Takeda, Shizuo Akira, Toshifumi Hibi   +14 more
openalex   +1 more source

Inflammatory Mediators in Uveitis: Differential Induction of Cytokines and Chemokines in Th1- Versus Th2-Mediated Ocular Inflammation [PDF]

, 2002
Ellen F. Foxman, Meifen Zhang, Stephen D. Hurst, Tony Muchamuel, Defen Shen, Eric F. Wawrousek, Chi‐Chao Chan, Igal Gery   +7 more
openalex   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

From sting to STING: role of inflammation in wasp sting induced AKI - a narrative review. [PDF]

BMC Nephrol
Xu L, Zhou Z, Lv Y, Li L, Yuan H, Sun Y, Hu F.   +6 more
europepmc   +1 more source

The tumor–microbe connection

Molecular Oncology, EarlyView.
Tumor‐associated bacteria (TAB) dynamically influence cancer biology by modulating tumor progression, metastatic spread, and therapeutic efficacy. Their presence redefines the tumor microenvironment (TME) as a microbial–host interface, yet mechanistic insights remain limited. Understanding TAB colonization routes, functional impacts, and crosstalk with
Gerlanda Vella, Maria Rescigno
wiley   +1 more source