Results 21 to 30 of about 4,346,916 (366)

Molecular Mechanisms of mtDNA-Mediated Inflammation [PDF]

Cells, 2021
Besides their role in cell metabolism, mitochondria display many other functions. Mitochondrial DNA (mtDNA), the own genome of the organelle, plays an important role in modulating the inflammatory immune response. When released from the mitochondrion to the cytosol, mtDNA is recognized by cGAS, a cGAMP which activates a pathway leading to enhanced ...
De Gaetano A., Solodka K., Zanini G., Selleri V., Mattioli A. V., Nasi M., Pinti M.   +6 more
openaire   +4 more sources

INFLAMMATION AS A FUNDAMENTAL PATHOLOGICAL PROCESS: LECTURE 1 (ALTERATION, VASCULAR REACTIONS)

Байкальский медицинский журнал, 2023
Inflammation is the most widespread pathological process in medical practice. Inflammation is the basis of the vast majority of diseases. In this connection, the topic is actual for any medical student, as well as a doctor of any specialty.
Svetlana N. Serebrennikova, Igor Zh. Seminsky, Evgenia V. Guzovskaiia, Liudmila O. Gutsol   +3 more
doaj   +1 more source

Targeting neuroinflammation in Alzheimer’s disease [PDF]

, 2016
Almost 47 million people suffer from dementia worldwide, with an estimated new case diagnosed every 3.2 seconds. Alzheimer’s disease (AD) accounts for approximately 60%–80% of all dementia cases. Given this evidence, it is clear dementia represents one
Bronzuoli, MARIA ROSANNA, Iacomino, Aniello, Scuderi, Caterina, Steardo, Luca   +3 more
core   +1 more source

Basal and PGF2α-stimulated secretion of pro-inflammatory cytokines from 3T3-L1 adipocyte-like cells [PDF]

BioDiscovery, 2017
Adipocytes were recently identified as an important source of endocrine and paracrine mediators, regulating the metabolism and activity of various cell types and body functions. 3T3-L1 preadipocytes are useful model for physiological, pharmacological and
Bilyana Ilieva, Elena Marinova, Hristo Gagov, Rossitza Konakchieva   +3 more
doaj   +3 more sources

Cytokines and chemokines as regulators of skeletal muscle inflammation: presenting the case of Duchenne muscular dystrophy [PDF]

, 2013
Duchenne muscular dystrophy is a severe inherited muscle disease that affects 1 in 3500 boys worldwide. Infiltration of skeletal muscle by inflammatory cells is an important facet of disease pathophysiology and is strongly associated with disease ...
De Bleecker, Jan, De Paepe, Boel
core   +3 more sources

The crucial roles of inflammatory mediators in inflammation: A review

Veterinary World, 2018
The inflammatory response is a crucial aspect of the tissues’ responses to deleterious inflammogens. This complex response involves leukocytes cells such as macrophages, neutrophils, and lymphocytes, also known as inflammatory cells.
Layth Abdulmajeed Abdulkhaleq, Layth Abdulmajeed Abdulkhaleq, M. Assi, R. Abdullah, M. Zamri-Saad, Y. Taufiq-Yap, M. Hezmee   +6 more
semanticscholar   +1 more source

Omega-3 fatty acid-derived mediators that control inflammation and tissue homeostasis.

International Immunology, 2019
Omega-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, display a wide range of beneficial effects in humans and animals.
T. Ishihara, Mio Yoshida, M. Arita
semanticscholar   +1 more source

Specialized Pro-Resolving Mediators in Neuroinflammation: Overview of Studies and Perspectives of Clinical Applications

Molecules, 2022
Specialized pro-resolving mediators (SPMs) are lipid mediators derived from poly-unsaturated fatty acids (PUFAs) which have been demonstrated to have an important role in the inflammation environment, preventing an overreaction of the organism and ...
Mariarosaria Valente, Marta Dentoni, Fabrizio Bellizzi, Fedra Kuris, Gian Luigi Gigli   +4 more
doaj   +1 more source

Channelling inflammation: gasdermins in physiology and disease

Nature reviews. Drug discovery, 2021
Gasdermins were recently identified as the mediators of pyroptosis — inflammatory cell death triggered by cytosolic sensing of invasive infection and danger signals.
Xing Liu, S. Xia, Zhibin Zhang, Hao Wu, J. Lieberman   +4 more
semanticscholar   +1 more source

Apolipoprotein E related Co-Morbidities and Alzheimer’s disease [PDF]

, 2016
The primary goal of advancement in clinical services is to provide a health care system that enhances an individual’s quality of life. Incidence of diabetes mellitus, cardiovascular disease and associated dementia coupled with the advancing age of the ...
Akiyama, Alharbi, Armitage, Armitage, Armitage, Balin, Barbieri, Bergdahl, Berliner, Borilova Linhartova, Borrell-Pages, Bowling, Braak, Braak, Brown, Bu, Buchanan, Burt, Cambell, Cavrini, Chiu, Chukkapalli, Chukkapalli, Chukkapalli, Cole, Corder, Corrada, Curtiss, Cutler, De Oliveira, DeFronzo, DeStefano, Desvarieux, Duarte, Epel, Farrer, Forner, Foster, Freitag-Wolf, Galbraith, Gan, Gao, Genco, Grehan, Grossi, Habib, Haffajee, Hajishengalis, Hajishengalis, Haraszthy, Hardardottir, Hardy, Harold, Harper, Hayashi, Hayden, Heiduschka, Helfand, Het, Hitt, Holt, Hu, Huang, Hunter, Hutton, Imhof, Iqbal, Itzhaki, Jagannathachary, Joiner, Kamer, Kamer, Kamer, Katz, Khovidhunkit, Klein, Kliegel, Kolovou, Kornman, Kozarov, Kubota, Lalla, Lambert, Lesne, Leszcynska, Libby, Machado, Mahley, Mahley, Mahley, Mahley, Maney, Marti, McGeer, Michalowicz, Miklossy, Miklossy, Miller, Mooradian, Moutsopoulos, Nagpal, Neto, Nicoll, Noble, Okuda, Olsen, Ono, O’Brien, Papapanou, Perls, Pitas, Pizzo, Poirier, Poling, Poole, Poole, Rivera, Riviere, Rogers, Rohn, Roses, Roses, Rowe, Saito, Saunders, Scannapieco, Schuett, Shao, Singhrao, Singhrao, Singhrao, Singhrao, Small, Smit, Socransky, Soscia, Stein, Strittmatter, Strittmatter, Sullivan, Velsko, Walsh, Walsh, Watkins, Weisgraber, Wetterau, Wilson, Young   +147 more
core   +1 more source