Results 21 to 30 of about 362,551 (290)

The Involvement of Lipid Mediators in the Mechanisms of Exercise-Induced Muscle Damage

Physiologia, 2023
Lipid mediators are a class of signaling molecules that play important roles in various physiological processes, including inflammation, blood pressure regulation, and energy metabolism.
Athanasios G. Gakis, Tzortzis Nomikos, Anastassios Philippou, Smaragdi Antonopoulou   +3 more
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Resolution of inflammation: Therapeutic potential of pro-resolving lipids in Type 2 diabetes mellitus and associated renal complications

Frontiers in Immunology, 2012
The role of inflammation in the pathogenesis of type 2 diabetes mellitus (T2DM) and its associated complications is increasingly recognized. The resolution of inflammation is actively regulated by endogenously produced lipid mediators such as lipoxins ...
Emma eBorgeson, Catherine eGodson
doaj   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Pro-inflammatory and pro-resolving lipid mediators of inflammation in HIV: effect of aspirin interventionResearch in context

EBioMedicine, 2023
Summary: Background: Persons with HIV (PWH) have an increased risk of cardiovascular disease (CVD) compared to HIV-seronegative individuals (SN). Inflammation contributes to this risk but the role of lipid mediators, with central roles in inflammation ...
Jesmond Dalli, Douglas Kitch, Meagan P. O'Brien, Peter W. Hunt, Nicholas Funderburg, Daniela Moisi, Amita Gupta, Todd T. Brown, Phyllis C. Tien, Judith A. Aberg, Rupak Shivakoti   +10 more
doaj   +1 more source

Gaseous mediators in resolution of inflammation

Seminars in Immunology, 2015
There are numerous gaseous substances that can act as signaling molecules, but the best characterized of these are nitric oxide, hydrogen sulfide and carbon monoxide. Each has been shown to play important roles in many physiological and pathophysiological processes.
Wallace, John L, IANARO, ANGELA, Flannigan, Kyle L., CIRINO, GIUSEPPE   +3 more
openaire   +5 more sources

TL1A: A mediator of gut inflammation [PDF]

Proceedings of the National Academy of Sciences, 2006
In this issue of PNAS, a team of investigators led by Giorgos Bamias and Fabio Cominelli at the University of Virginia Health Science Center (Charlottesville, VA) in collaboration with the laboratory of Giorgos Kollias at the Alexander Fleming Biomedical Sciences Research Center (Athens, Greece) report on the role of TL1A (a TNF superfamily member) in ...
Howard A. Young, Michael G. Tovey
openaire   +3 more sources

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Sequential release of cytokines, lipid mediators and nitric oxide in experimental colitis

Mediators of Inflammation, 1995
The object of this study was to establish whether different pro- and anti-inflammatory mediators were formed in colonic tissue from experimental colitis depending on the course of the disease.
A. P. M. van Dijk, Z. J. Keuskamp, J. H. P. Wilson, F. J. Zijlstra   +3 more
doaj   +1 more source