Driving chronicity in rheumatoid arthritis: perpetuating role of myeloid cells [PDF]
, 2018 Acute inflammation is a complex and tightly regulated homeostatic process that includes leukocyte migration from the vasculature into tissues to eliminate the pathogen/injury, followed by a pro-resolving response promoting tissue repair.
Achuthan +115 more
core +1 more source
The Chemokine CCL2 Mediates the Seizure-enhancing Effects of Systemic Inflammation [PDF]
, 2016 Epilepsy is a chronic disorder characterized by spontaneous recurrent seizures. Brain inflammation is increasingly recognized as a critical factor for seizure precipitation, but the molecular mediators of such proconvulsant effects are only partly ...
Allegra, M +8 more
core +2 more sources
Adipokines: mediators of immunity and inflammation [PDF]
, 2020 White adipose tissue has emerged as a highly dynamic organ that releases a plethora of immune and inflammatory mediators that are involved in obesity, metabolic syndrome and immune mediated diseases.
Bansal, Tarun, Kharbanda, Rajat
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Computational evidence for an early, amplified systemic inflammation program in polytrauma patients with severe extremity injuries [PDF]
, 2019 Extremity and soft tissue injuries contribute significantly to inflammation and adverse in-hospital outcomes for trauma survivors; accordingly, we examined the complex association between clinical outcomes inflammatory responses in this setting using in ...
Abboud, Andrew +10 more
core +1 more source
Role of Extracellular Vesicles in Cell Death and Inflammation
Cells, 2021 Extracellular vesicles (EVs) have been identified as novel mediators of intercellular communication. They work via delivering the sequestered cargo to cells in the close vicinity, as well as distant sites in the body, regulating pathophysiological ...
Rahul Sanwlani, Lahiru Gangoda
doaj +1 more source
Targeting V-ATPase in human monocytes and macrophages to manipulate inflammation-related mediators [PDF]
, 2020 Inflammation is a self-defensive process by the immune system that helps the body to return to homeostasis. Professional innate immune cells with pivotal functions in the immune defense like human monocytes, M1 and M2 macrophages produce abundant levels ...
Rao, Zhigang
core +1 more source
Microglial memory of early life stress and inflammation: susceptibility to neurodegeneration in adulthood [PDF]
Neurosci Biohav Rev 2019, 2019 We review evidence supporting the role of early life programming in the susceptibility for adult neurodegenerative diseases while highlighting questions and proposing avenues for future research to advance our understanding of this fundamental process.
arxiv +1 more source
DNA damage mediates changes in neuronal sensitivity induced by the inflammatory mediators, MCP-1 and LPS, and can be reversed by enhancing the DNA repair function of APE1 [PDF]
, 2017 Although inflammation-induced peripheral sensitization oftentimes resolves as an injury heals, this sensitization can be pathologically maintained and contribute to chronic inflammatory pain.
Fehrenbacher, Jill C. +3 more
core +1 more source
Resolving an inflammatory concept: the importance of inflammation and resolution in tendinopathy [PDF]
, 2014 Injuries to the superficial digital flexor tendon (SDFT) are an important cause of morbidity and mortality in equine athletes, but the healing response is poorly understood.
Abayasekara +91 more
core +1 more source
Mast cells as the strength of the inflammatory process
Polish Journal of Pathology, 2017 The inflammatory process is a complex host defence mechanism aimed at the elimination of deleterious factors disturbing homeostasis. Inflammation consists of several interdependent stages controlled by a wide range of mediators. Those include acute phase
Joanna Pastwińska +3 more
doaj +1 more source