Results 231 to 240 of about 4,054,897 (306)

Vascular Disease, Non‐Steroidal Anti‐Inflammatory Drugs and Risk of Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives A history of vascular disease has been shown to be associated with an increased risk of Parkinson's disease, but this may be due to reverse causation. In addition, non‐steroidal anti‐inflammatory drugs are thought to reduce Parkinson's disease risk, but evidence is inconsistent and confounding by prior vascular disease is possible ...
Clare Wotton, Carol Hermon, Sarah Floud, Gillian Reeves, Isobel Barnes   +4 more
wiley   +1 more source

Extracellular ATP Signaling as a Proposed Mechanistic Link to Cellular Senescence in Cardiovascular Diseases. [PDF]

J Inflamm Res
Liu X, Zhang J, Lu J, Hu Z, Wei H, Li L, Yang Y, Liu J, Li Z, Zhang H, Zhang W.   +10 more
europepmc   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Effects of <i>Corydalis saxicola</i> Bunting total alkaloids on lipopolysaccharide-induced inflammatory responses in human oral epithelial cells. [PDF]

Biomed Rep
Qin Y, Lai Y, Wu J, Jiang Q, Su Z, Liu Z, Tao R, Yong X.   +7 more
europepmc   +1 more source

Fatty acid dysregulation in asthma: linking immunometabolic remodeling, phenotypic heterogeneity, and metabolic precision medicine. [PDF]

Front Immunol
Yuan Y, Peng Y.
europepmc   +1 more source

Mechanistic Insights Into How Acupuncture Modulates Host Immunity via the Gut Microbiota-Macrophage Axis. [PDF]

Immun Inflamm Dis
Yang T, Li M, Wu X.
europepmc   +1 more source