Results 141 to 150 of about 371,945 (298)

Dual‐Functional Ingestible Passive Capsules for High‐Throughput Intestinal Sampling with Sealed Containment and Targeted Drug Delivery

Advanced Robotics Research, EarlyView.
To address challenges in high‐throughput intestinal sampling with sealed containment and target drug delivery, we developed a dual‐functional ingestible passive capsule with a dual‐triggered control system based on pH‐response and mechanical actuation.
Libing Huang, Houyu Ling, Xizong Chen, Yufei Duan, Yu Liu, Shuntian Cai, Yandan Ren, Wenlong Li, Lei Ren, Miao Wang   +9 more
wiley   +1 more source

Colonic Tissue Expression of MAdCAM‐1 Is Not Predictive of Vedolizumab Responsiveness in Inflammatory Bowel Disease

Clinical and Translational Science
We assessed the predictive value of MAdCAM‐1 expression on response to vedolizumab in patients with inflammatory bowel disease. This was a retrospective, single‐center, cohort study including 109 patients with pretreatment inflammation who completed at ...
Nikhil Reddy, Jeremy A. Klein, Nikita Thomas, Dejan Micic, Zifeng Deng, David T. Rubin, Russell D. Cohen, Sushila Dalal, Britt Christensen, Haider I. Haider, Vesta Valuckaite, Katherine R. Meckel, Marc Bissonnette, Christopher R. Weber, Joel Pekow   +14 more
doaj   +1 more source

Tumbling Magnetic Microrobots for Targeted In Vivo Drug Delivery in the GI Tract

Advanced Robotics Research, EarlyView.
We introduce a microrobot design and integrated system for on‐demand targeted drug release in the gastrointestinal tract. The microrobot has an embedded magnet for actuation with external magnetic fields and is visualized in real time using ultrasound. It has two drug release ports sealed with a thermally sensitive wax. Local heating of the wax using a
Aaron C. Davis, Luis Carlos Sanjuan Acosta, Shubh P. Mehta, Baiyan Qi, Yang Yang, Luis Solorio, Craig J. Goergen, David J. Cappelleri   +7 more
wiley   +1 more source

Association of extraintestinal manifestations of inflammatory bowel disease in a province of western Hungary with disease phenotype: Results of a 25-year follow-up study

, 2003
AIM: IBD is a systemic disease associated with a large number of extraintestinal manifestations (EIMs). Our aim was to determine the prevalence of EIMs in a large IBD cohort in Veszprem Province in a 25-year follow-up study.
Dávid, Gyula, Balogh, Zsuzsanna, Tollas, Árpád, Lakatos, Péter László, Pandur, Tünde, Kuronya, Pál, Lakatos, László   +6 more
core  

High Humidity Exacerbates Psoriasiform Skin Disease Relapse by Increasing Tissue‐Resident Memory T Cells via Altering Skin Microbiota

Advanced Science, EarlyView.
We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang, Yuchao Chen, Chuanjian Lu, Huazhen Liu, Fenglian Qin, Sisi Dai, Feifei Qiu, Haiming Chen, Weihui Lu, Jonathan S. Bromberg, Zhenhua Dai   +10 more
wiley   +1 more source

Pharmacological treatment of inflammatory bowel disease

, 2015
Pharmacological therapy of inflammatory bowel disease with their potential side effect. Supportive therapy and surgical treatment methods.Epidemiology , etiology and pathogenesis. Complication in pregnant women.
Njikam Chamna, Laurence
core  

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

The resolvin D2 and omega-3 polyunsaturated fatty acid as a new possible therapeutic approach for inflammatory bowel diseases

Scientific Reports
Inflammatory bowel diseases (IBD) are idiopathic disorders characterized by chronic gastrointestinal inflammation. Given conventional therapies’ adverse effects and clinical failures, novel approaches are being investigated.
Fabio Henrique Mendonça Chaim, Lívia Bitencourt Pascoal, Marina Moreira de Castro, Bruna Biazon Palma, Bruno Lima Rodrigues, João José Fagundes, Marciane Milanski, Luiz Roberto Lopes, Raquel Franco Leal   +8 more
doaj   +1 more source

Inflammatory bowel disease: clinical aspects and treatments

, 2014
Marc Fakhoury,1 Rebecca Negrulj,2 Armin Mooranian,2 Hani Al-Salami2 1Biomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering and Artificial Cells and Organs Research Center, Faculty of Medicine, McGill University,
Al-Salami H, Fakhoury M, Negrulj R, Mooranian A   +3 more
core  

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source