Results 231 to 240 of about 3,225,863 (285)

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

Coordinated Interferon-γ/Tumor Necrosis Factor Axis Drives Selective Loss of Activated Enteric Glia in Inflammatory Bowel Diseases. [PDF]

Cell Mol Gastroenterol Hepatol
Bubeck M, Penkert KA, Limberger H, Acera MG, Plattner C, Ziegler S, Muppirala A, Forster P, Jakob M, Gamez-Belmonte R, Erkert L, Kulkarni S, Günther C, Atreya R, Kühl AA, Hegazy AN, Hildner K, Trajanoski Z, Siegmund B, Neurath MF, IBDome Consortium, Rao M, Progatzky F, Lie DC, Becker C, Romagnani C, Ludwig LS, Klose CSN, Patankar JV.   +28 more
europepmc   +1 more source

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

The role of hepcidin in the inflammatory and iron homeostasis axis in inflammatory bowel diseases: a systematic review. [PDF]

Transl Gastroenterol Hepatol
Parreira LF, Teixeira AVR, Siqueira SSN, Siqueira NSN, de Castro MM, Genaro LM, Pereira IM, Gallina NC, Leal RF.   +8 more
europepmc   +1 more source

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source

A review of inflammatory bowel diseases in humans and pets: treatment strategies. [PDF]

Vet Res Forum
Abtahi Froushani SM, Hasani SJ, Ghaderi M, Mahmoudzadeh L.   +3 more
europepmc   +1 more source

Recent Advances in the Utilization of Dietary-Derived Exosome-like Nanoparticles in Inflammatory Bowel Diseases. [PDF]

Foods
Lin Z, Cui Y, Wang J, Yu Y, Tan C.
europepmc   +1 more source

Dysfunction of mitochondria in intestinal epithelial cells: a key player in the pathogenesis of inflammatory bowel diseases. [PDF]

Gastroenterol Rep (Oxf)
Pang J, Jiang M, Jia Y, Li L, Li Y, Zhang H, Chen Y, Chen K, Lin H, Chen J, Li J, Shen Y, Xiang Z, Zhang H.   +13 more
europepmc   +1 more source

Multicenter experience using tofacitinib for treatment of refractory pediatric inflammatory bowel diseases in the United States. [PDF]

J Pediatr Gastroenterol Nutr
Young DD, Murphy JE, Chavannes M, Dotson JL, Tung J, Chang E, Pasternak B, Crawford E, McGreal N, Moses J, Kim SC.   +10 more
europepmc   +1 more source

The multifaceted role of sirtuins in inflammatory bowel diseases. [PDF]

Am J Physiol Gastrointest Liver Physiol
Samant SA, Hyoju SK, Alverdy JC, Gupta MP.   +3 more
europepmc   +1 more source