Results 151 to 160 of about 291,938 (249)

Clinical Significance and Prognostic Value of TLR4 and AGER in Inflammatory Breast Cancer. [PDF]

Cancers (Basel)
Paiva LDAS, Teles ACF, Souza JDS, Oliveira PRA, Alves BES, Coelho MTB, Cajado AG, Maia IFVC, Silva PGB, Cavalcante DIM, Cunha MDPSS, Arruda LM, Lima-Júnior RCP, Rogatto SR, Wong DVT.   +14 more
europepmc   +1 more source

The E3 Ligase RNF115 Aggravates Pathological Cardiac Hypertrophy via Ubiquitin‐Mediated Degradation of SPTBN1

Advanced Science, EarlyView.
In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu, Shiqing Chen, Ji Chen, Liuliu Ruan, Bowen Li, Weijian Chu, Shichen Huang, Dian Yu, Jing Tian, Yuhan Zhao, Yi Han, Xin Tang, Yong Ji   +12 more
wiley   +1 more source

Exome sequencing reveals new insights into the germline landscape of inflammatory breast cancer among Tunisian patients. [PDF]

J Transl Med
Boujemaa M, Hamdi Y, Guidara S, Souissi A, Bouaziz H, Mejri N, Aloulou S, Mahjoub N, Chaabane K, Hakim H, Boussen H, Dhiab TB, Kamoun S, Ayadi R, Driss M, Ayadi A, Radouani F, Fakhkhari M, Khyatti M, Abdelhak S, Sadki K, Boubaker MS, Rebai A, Cherif B.   +23 more
europepmc   +1 more source

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source

Development of a multi-institutional dataset to validate a novel inflammatory breast cancer diagnostic score. [PDF]

J Natl Cancer Inst
Lynce F, Niman SM, Kai M, Ryan S, Troll E, Li L, Miller KD, Jagsi R, Mason G, Overmoyer BA, Le-Petross HTC, Nakhlis F, Krishnamurthy S, Harrison BT, Sun SX, Yeh ED, Bellon JR, Warren LE, Stauder MC, Regan MM, Woodward WA.   +20 more
europepmc   +1 more source

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

Comparative outcomes of operable non-inflammatory and non-metastatic inflammatory breast cancer in Morocco: a retrospective cohort study. [PDF]

Front Oncol
Ismaili N, Guessous F, El Majjaoui S.
europepmc   +1 more source

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

Integrative analysis of bulk and single-cell transcriptomics identifies factors related to immunosuppressive microenvironment to predict unfavorable prognosis in inflammatory breast cancer. [PDF]

Front Immunol
Feng K, Li X, Li X, Liu J, Zhang R, Chen H, Zhang Y, He J, Zhang H.   +8 more
europepmc   +1 more source

Spatiotemporal Targeting Randle Cycle and Immune Checkpoint for Potent Antitumor Therapy

Advanced Science, EarlyView.
A glucose oxidase‐based nanogel (GOX‐NG) system using catechol‐functionalized alginate, exhibits enhanced tumor penetration, prolonged retention, and sustained glucose depletion in the tumor microenvironment. When combined with a fatty acid oxidation inhibitor, it implements dual metabolic suppression, thereby enhancing ROS‐induced immunogenic cell ...
Yuan Gao, Zijian Gong, Yixuan Fu, Jianan Zheng, Xiao Sang, Binglin Chen, Qinzhi Su, Weiping Gao, Fei Duan, Jinqi Wei, Xuliang Deng, Xinyu Liu   +11 more
wiley   +1 more source