Results 61 to 70 of about 1,114,936 (208)

Microglial Labeling in Mouse Spinal Cord Injury: A Review of Timing, Efficacy, and Specificity

Glia, Volume 74, Issue 12, December 2026.
The transcriptional profile of microglia is significantly altered after spinal cord injury (SCI). When choosing a marker to label microglia after SCI, it is important to consider its specificity for microglia and its stability of expression. ABSTRACT Traumatic spinal cord injury (SCI) is a complex and disabling condition with no curative therapy ...
Ruth Colbert, Julia Di Stefano, Dearbhaile Dooley   +2 more
wiley   +1 more source

Idiopathic multifocal choroiditis

Journal of Ophthalmic & Vision Research, 2016
Idiopathic multifocal choroiditis (MFC) and/or punctate inner choroidopathy (PIC) describe a chronic progressive bilateral inflammatory chorioretinopathy that predominantly affect healthy myopic white women with no known associated systemic or ocular ...
Ali Tavallali, Lawrence A Yannuzzi
doaj   +1 more source

Macrophages inhibit neovascularization in a murine model of age-related macular degeneration. [PDF]

PLoS Medicine, 2006
Age-related macular degeneration (AMD) is the leading cause of blindness in people over 50 y of age in at least three continents. Choroidal neovascularization (CNV) is the process by which abnormal blood vessels develop underneath the retina.
Rajendra S Apte, Jennifer Richter, John Herndon, Thomas A Ferguson   +3 more
doaj   +1 more source

Ocular Manifestations of Metabolic Syndrome: A Systemic Vascular Phenotype

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 9809-9818, November 2026.
ABSTRACT Context Metabolic syndrome (MetS) is defined by central obesity, insulin resistance, hypertension and dyslipidemia. MetS affects over one‐third of US adults. Beyond its cardiovascular burden, MetS has clinically relevant associations with ocular health and may contribute to a systemic vascular and neuro‐metabolic phenotype involving the retina,
Ron T. Varghese, Ansu A. John
wiley   +1 more source

Inflammatory choroidal neovascular membrane in posterior uveitis-pathogenesis and treatment

Indian Journal of Ophthalmology, 2010
Choroidal neovascular membrane (CNVM) formation is a well-documented sight-threatening complication of posterior segment intraocular inflammation (PSII). The aim of this article is to review the basic and clinical science literature on the pathogenesis of CNVM formation in PSII and to present results of a case series.
Dhingra Narendra, Kelly Susan, Majid Mohammed, Bailey Claire, Dick Andrew   +4 more
openaire   +3 more sources

Data_Sheet_1_Caffeine Inhibits Choroidal Neovascularization Through Mitigation of Inflammatory and Angiogenesis Activities.PDF

, 2021
Adenosine receptors (AR) are widely expressed in a variety of tissues including the retina and brain. They are involved in adenosine-mediated immune responses underlying the onset and progression of neurodegenerative diseases.
Ismail S. Zaitoun (11561584), Christine M. Sorenson (8763522), Colleen M. McDowell (9268234), Yong-Seok Song (5905106), Ryan M. McAdams (10151084), Zafer Gurel (558017), Nader Sheibani (135061), Debra L. Fisk (9307406), Barbara A. Hanna (11561587), Soesiawati R. Darjatmoko (4715220), Shoujian Wang (680228)   +10 more
core   +1 more source

Microglial repopulation restricts ocular inflammation and choroidal neovascularization in mice

Frontiers in Immunology
IntroductionAge-related macular degeneration (AMD) is a prevalent, chronic and progressive retinal degenerative disease characterized by an inflammatory response mediated by activated microglia accumulating in the retina.
Yinting Song, Yuefeng Liao, Tong Liu, Yanxian Chen, Yanxian Chen, Fei Wang, Zixia Zhou, Weili Zhang, Jinying Li   +8 more
doaj   +1 more source

RPE disruption and hyper-transmission are early signs of secondary CNV with punctate inner choroidopathy in structure-OCT

BMC Ophthalmology, 2021
Purpose To study whether retinal pigment epithelium (RPE) disruption and choroidal hyper-transmission on spectral-domain optical coherence tomography (SD-OCT) are signs of inflammatory neovascularization (CNV) in punctate inner choroidopathy (PIC ...
Yanru Chen, Qian Chen, Xiaoxin Li, Minghan Li   +3 more
doaj   +1 more source

From Molecular Targets to Advanced Delivery Systems: Aptamers for Precision Ocular Therapeutics

Advanced Therapeutics, Volume 9, Issue 10, October 2026.
Aptamer‐based strategies are revolutionizing ocular disease management through highly specific molecular recognition of disease specific molecular targets. This review systematically integrates therapeutic aptamer sequences, diagnostic aptasensor platforms, and targeted delivery strategies, highlighting design principles, ocular bioavailability ...
Minal Thacker, Ka‐Ying Wong, Liping Zhou, Man‐Sau Wong, Juewen Liu   +4 more
wiley   +1 more source

Nanoprobe‐Enabled Precision Imaging and Panoramic Boundary Delineation in Retinoblastoma

Cancer Innovation, Volume 5, Issue 5, October 2026.
This review highlights that nanoprobe‐enabled multimodal imaging, combined with targeted probe design and AI‐assisted analysis, significantly enhances the precise visualization and boundary delineation of retinoblastoma. It further outlines key challenges and directions for translating high‐performance imaging nanoprobes into clinical practice.
Xuefei He, Precious Amarachi Ikwuagwu, Wenjing Pang, Aomen Chen, Lingchao Xiang, Feng Chen, Chen Xu, Aiguo Wu   +7 more
wiley   +1 more source