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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a clinically heterogeneous neurodegenerative disease requiring reliable biomarkers to improve patient stratification and trial design. While serum neurofilament light chain (sNfL) reflects neuroaxonal stress and disease aggressiveness, troponin T (TnT) may capture complementary aspects of ...
Julia Sellin +8 more
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The inflammatory response to anthralin
Clinical and Experimental Dermatology, 1984Summary The inflammatory dose-response of the skin to topical anthralin was measured in patients with psoriasis, and compared with the response in a group consisting of normal subjects and patients with unrelated skin diseases. Wide individual variation was demonstrated but there was no significant difference between individuals with and without ...
C M, Lawrence, D, Howel, S, Shuster
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The inflammatory response in the CNS
Neuropathology and Applied Neurobiology, 1992In recent years it has been recognized that cells of the mononuclear phagocyte lineage, macro‐phages and microglia, are a major component of gliosis. We review here studies on the kinetics of the myelomonocytic response to acute excitotoxin induced neuronal degeneration and following the injection of endotoxin (LPS) into the parenchyma of the central ...
Perry, V.H., Andersson, P.B.
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The spectrum of inflammatory responses
Science, 2021Inflammation is an integral part of animal biology. It provides critical protection from adverse environmental factors by enforcing the defense of homeostasis and the functional and structural integrity of tissues and organs. Recent advances have uncovered a broad range of biological processes that involve inflammatory control, calling for a renewed ...
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Prostaglandins and the Inflammatory Response
Clinics in Laboratory Medicine, 1983Prostaglandins not only mediate the classic signs of inflammation but also help to regulate the function of cellular constituents in an inflammatory reaction. Clinical and experimental evidence of the role of prostaglandins as mediators is highlighted.
J S, Bomalaski +2 more
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Lactoferrin and the Inflammatory Response
1994Polyclonal antibodies were prepared to purified breast milk lactoferrin and used in an ELISA to measure plasma concentrations in investigations of various aspects of the inflammatory response. They were also used, in situ, to evaluate granulocyte lactoferrin content in disease states.
R D, Baynes, W R, Bezwoda
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Inflammatory Responses to Biomaterials
American Journal of Clinical Pathology, 1995Implanted biomedical devices are of increasing importance in modern medical care. However, surprisingly little is known of the factors that determine biocompatibility of the materials used in these devices. These materials, although generally inert and non-toxic, can mediate a variety of adverse reactions, including inflammation, fibrosis, coagulation,
L, Tang, J W, Eaton
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Mechanisms of the inflammatory response
Best Practice & Research Clinical Anaesthesiology, 2004The physiological alterations induced by acute inflammation present significant management challenges for anaesthesiologists. Major surgery, trauma, burns and sepsis all have large inflammatory components. Acute inflammation is characterized by vasodilatation, fluid exudation and neutrophil infiltration. These processes are activated and amplified by a
Edward R, Sherwood +1 more
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Platelets and the Inflammatory Response
Clinics in Laboratory Medicine, 1983The involvement of platelets with inflammatory mediators, synthesized and/or released on contact with inflammatory signals, has recently been defined. Localized interactions of platelets and neutrophils with the blood vessel wall and with each other represent another part platelets play in the modulation of inflammatory responses.
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The inflammatory response to endotoxin
The Journal of Pathology, 1979A typical inflammatory response resulted from the intravenous injection of endotoxin (E. coli) into living rabbits. Each rabbit was studied at three levels: the microvasculature and supporting tissue in the ear chamber was observed microscopically (up to X200) before, during, and at regular intervals following the injection of endotoxin; leucocyte and ...
M L, Goodman, B A, Way, J W, Irwin
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