Results 81 to 90 of about 8,132,737 (308)

Mitochondrial and lipid metabolism rewiring during HEV infection

Cellular and Molecular Life Sciences
Hepatitis E virus (HEV), a leading cause of acute and chronic viral hepatitis, poses a persistent global health challenge. A deeper mechanistic understanding of virus–host interactions is critical for identifying therapeutic targets to mitigate HEV ...
Quentin Glaziou, Qian Chen, Jordi Gouilly, Ming Wu, Marie Duhamel, Michel Salzet, Jacques Izopet, Reem Al Daccak, Hicham El Costa, Nabila Jabrane-Ferrat   +9 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The associations between p,p’-DDE levels and plasma levels of lipoproteins and their subclasses in an elderly population determined by analysis of lipoprotein content

Lipids in Health and Disease, 2020
Background Lipoproteins at aberrant levels are known to play a role in cardiovascular disease. The metabolite of the insecticide dichlorodiphenyltrichloroethane (DDT), p,p’-dichlorodiphenyldichloroethylene (p,p’-DDE), physically associates with lipids ...
Juliann Jugan, P. Monica Lind, Samira Salihovic, Jordan Stubleski, Anna Kärrman, Lars Lind, Michele A. La Merrill   +6 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

An Overview of Ischemia–Reperfusion Injury: Review on Oxidative Stress and Inflammatory Response

, 2022
Ischemia-reperfusion is a common health problem leading to several health conditions. The pathophysiology of ischemia-reperfusion is quite complex. Oxidative stress and inflammatory response contribute to ischemia-reperfusion mechanisms.
TANYELİ, AYHAN, Tuncer Nacar, ERASLAN, ERSEN, NACAR, TUNCER, ÖZBEK ŞEBİN, SAİME, Mustafa Can Güler, GÜZEL ERDOĞAN, DERYA, Ayhan Tanyeli, Fazile Nur Ekinci Akdemir, GÜLER, MUSTAFA CAN, Ersen Eraslan, Derya Güzel Erdoğan, EKİNCİ AKDEMİR, FAZİLE NUR, Saime Özbek Şebin   +13 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

CARD8 polymorphisms among bacterial meningitis patients in North-West Ethiopia

BMC Infectious Diseases
Background The severity of infectious disease outcomes is dependent on the virulence factors of the pathogen and the host immune response. CARD8 is a major regulator of the innate immune proinflammatory response and has been suggested to modulate the ...
Meseret Belayneh, Mesfin Mengesha, Berhane A. Idosa, Surafel Fentaw, Biniyam Moges, Zelalem Tazu, Meseret Assefa, Örjan Garpenholt, Alexander Persson, Eva Särndahl, Ebba Abate, Olof Säll, Baye Gelaw   +12 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Genetic dysbiosis: the role of microbial insults in chronic inflammatory diseases [PDF]

, 2014
Thousands of bacterial phylotypes colonise the human body and the host response to this bacterial challenge greatly influences our state of health or disease. The concept of infectogenomics highlights the importance of host genetic factors in determining
Syed Tariq Sadiq, Nibali, L, Luigi Nibali, Henderson, B, Sadiq, ST, Brian Henderson, Donos, N, Nikos Donos   +7 more
core   +2 more sources

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source