Results 191 to 200 of about 10,871 (266)

Cross‐Organ Multi‐Omics Profiling of Systemic Alterations in 5xFAD Mice and Changes Associated with Huanglian Jiedu Decoction Treatment

open access: yesAdvanced Science, EarlyView.
Cross‐organ multi‐omics reveals coordinated inflammatory and metabolic disturbances in 5xFAD mice. Huanglian Jiedu Decoction improves cognition and alleviates brain and liver abnormalities. Complementary hepatocyte–microglia conditioned‐medium experiments suggest PPAR‐γ involvement in treatment‐associated changes in microglial inflammation, providing ...
Wenya Gao   +10 more
wiley   +1 more source

Enhancing Surface Icephobic Performance via Spontaneous Fracture Characteristics of Ice Crystals Regulated by Structural Scale Under Shear Flow Conditions

open access: yesAdvanced Science, EarlyView.
Aerodynamic shear induces spontaneous ice fracture and detachment on hydrophobic surfaces, governed by the interplay between initial ice‐crystal size, growth orientation, and interfacial adhesion. Unexpectedly, microstructural anchoring on superhydrophobic surfaces suppresses ice shedding.
Jiawei Jiang   +8 more
wiley   +1 more source

Adaptive Cellular Responsiveness to Electrical Stimulation at the Skin‐Electrode Interface

open access: yesAdvanced Science, EarlyView.
This study presents an adaptive bioelectronic response in which sustained electrical stimulation (ES) upregulates voltage‐gated calcium channels (VGCCs) and enhances cellular sensitivity to subsequent ES at the skin‐device interface. VGCC‐associated adaptive sensitization promotes regenerative wound‐healing responses in vivo, including accelerated ...
Yeon Jae Chang   +11 more
wiley   +1 more source

Desertification monitoring in arid oasis environment using Google Earth Engine, machine learning, and field-based hydrogeological assessment. [PDF]

open access: yesSci Rep
Moumane A   +8 more
europepmc   +1 more source

A Mechanistic Dissection of Multifaceted Complement Attack in Age‐Related Macular Degeneration Reveals the Superiority of C3 Inhibition

open access: yesAdvanced Science, EarlyView.
Complement‐mediated RPE degeneration extends beyond terminal MAC injury. A four‐hit mechanism emerges in which C3a and C5a disrupt mitochondrial function, while C3b and MAC compromise the phagolysosomal system. Upstream C3 inhibition suppresses this full spectrum of pathogenic effectors, providing broader cellular protection than C5 blockade.
Zhidong Chen   +3 more
wiley   +1 more source

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