Results 31 to 40 of about 570,997 (263)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Malignant rhabdoid tumor of the kidney (MRTK) is a rare, aggressive tumor seen in young children. The optimal timing of resection for locally advanced tumors is not well‐defined. The purpose of this study is to evaluate modern oncologic outcomes and the impact of surgical timing. Methods A multicenter retrospective review was performed
Hannah N. Rinehardt +76 more
wiley +1 more source
NONLINEAR RESPONSE ANALYSIS OF DOUBLE DISK RUBBING ROTOR-OIL FILM BEARING SYSTEM
Jixie qiangdu, 2020 In order to describe rotor-bearing system more accurately and to consider the influence of nonlinear oil film force and rubbing force,this paper establishes a single disk rubbing rotor-bearing system model with nonlinear support,and deduces the ...
LIU JunJie +3 more
doaj
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction Patients with ovarian cancer often present with massive ascites, leading to significant protein loss during surgical procedures. Although cell‐free concentrated ascites reinfusion therapy (CART) is used in palliative settings to mitigate protein loss, its application in intraoperative settings remains unexplored.
Yutaka Yoneoka +7 more
wiley +1 more source
, 2013 We describe a mechanism for performing probabilistic reasoning in influence diagrams using interval rather than point valued probabilities. We derive the procedures for node removal (corresponding to conditional expectation) and arc reversal (corresponding to Bayesian conditioning) in influence diagrams where lower bounds on probabilities are stored at
Fertig, Kenneth W., Breese, John S.
openaire +2 more sources
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
APPROPRIATE ALLOCATION OF CONTINGENCY USING RISK ANALYSIS METHODOLOGY
Civil Engineering Dimension, 2004 Many cost overruns in the world of construction are attributable to either unforeseen events or foreseen events for which uncertainty was not appropriately accommodated.
Andi Andi
doaj
The impact of visualization on flexible Bayesian reasoning
Avances de Investigación en Educación Matemática, 2017 There is wide consensus that visualizations of statistical information can support Bayesian reasoning. This article focusses on the conceptual understanding of Bayesian reasoning situations and investigates whether the tree diagram or the unit square is
Katharina Böcherer-Linder +2 more
doaj +1 more source