Results 51 to 60 of about 603,763 (263)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Assessing the feasibility of use of SCAD software to build influence line of the bending moment [PDF]
Строительство уникальных зданий и сооружений, 2014 This article describes a method for building the influence line of bending moments in statically indeterminate 2d frame using SCAD software. The result is compared with the bending moment diagram obtained in SCAD software. Then there is an analysis
Aleksey Vladimirovich Savchenko +2 more
doaj
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
APPROPRIATE ALLOCATION OF CONTINGENCY USING RISK ANALYSIS METHODOLOGY
Civil Engineering Dimension, 2004 Many cost overruns in the world of construction are attributable to either unforeseen events or foreseen events for which uncertainty was not appropriately accommodated.
Andi Andi
doaj
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Analysis of Gear Dynamic Characteristic of Oil Churning Resistance under Stochastic Disturbance
Jixie chuandong, 2022 Oil churning lubrication is an important lubrication method of gear system. Considering the viscoelasticity of the lubricant oil will result in additional resistance upon gears immersed in the oil while running at high-speed，and the gear system can get ...
Wenyu Liu +4 more
doaj
The impact of visualization on flexible Bayesian reasoning
Avances de Investigación en Educación Matemática, 2017 There is wide consensus that visualizations of statistical information can support Bayesian reasoning. This article focusses on the conceptual understanding of Bayesian reasoning situations and investigates whether the tree diagram or the unit square is
Katharina Böcherer-Linder +2 more
doaj +1 more source