Results 61 to 70 of about 603,763 (263)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Magnetic phase diagram of YbRh_{2}Si_{2}: The influence of hyperfine interactions
Physical Review ResearchWe report the determination of the magnetic phase diagram of the heavy fermion metal YbRh_{2}Si_{2} in magnetic fields up to 70 mT applied perpendicular to the crystallographic c axis.
J. Knapp +8 more
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Фармацевтичний журнал, 2019 The results obtained based on the random balance method are usually presented using scattering diagrams. Their number corresponds to the number of criteria for evaluation, since both impact factors and evaluation criteria can be measured by different ...
I. Revyatskyy, O. Barchuk
doaj +1 more source
Nonlinear Model and Dynamic Behavior of Photovoltaic Grid-Connected Inverter
Applied Sciences, 2020 A photovoltaic grid-connected inverter is a strongly nonlinear system. A model predictive control method can improve control accuracy and dynamic performance.
Zhi-Xian Liao +7 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Jixie chuandong, 2019 In order to study the influence of the random perturbation of time-varying mesh stiffness on the dynamics of the helical gearing system, based on Newton's law, a stochastic dynamics model of a six-degree-of-freedom helical gear system is established and ...
Yiyi Tou +4 more
doaj
Investigation of the Thermodynamic Process of the Refrigerator Compressor Based on the m-θ Diagram
Energies, 2017 The variation of refrigerant mass in the cylinder of refrigerator compressor has a great influence on the compressor’s thermodynamic process. In this paper, the m-θ diagram, which represents the variation of refrigerant mass in compressor cylinder (m ...
Tao Wang +3 more
doaj +1 more source