Results 81 to 90 of about 570,997 (263)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Fundamental study of cornering limit characteristics of motorcycles during braking and driving

Nihon Kikai Gakkai ronbunshu, 2017
Sport riding performance on racing circuits and other locations is seen as an important element in the marketability of motorcycles. In sport riding, some riders start a turn while braking or start acceleration (driving) while turning.
Hideki SAKAI
doaj   +1 more source

Gait Influence Diagrams in Parkinson’s Disease

IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2017
Previous studies have shown that gait patterns differ between Parkinson's disease (PD) patients and controls. However, almost all these studies focused only on univariate time series of a single variable. This approach cannot reveal detailed information of foot loading dynamics and the cooperative relationships of different anatomical plantar foot ...
Peng, Ren, Esin, Karahan, Chao, Chen, Ruixue, Luo, Yayuan, Geng, Jorge Francisco, Bosch Bayard, Maria L, Bringas, Dezhong, Yao, Keith M, Kendrick, Pedro A, Valdes-Sosa   +9 more
openaire   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Nonlinear Dynamic Analysis of Rotor Rub-Impact System

Shock and Vibration, 2019
A dynamic model of a double-disk rub-impact rotor-bearing system with rubbing fault is established. The dynamic differential equation of the system is solved by combining the numerical integration method with MATLAB.
Youfeng Zhu, Zibo Wang, Qiang Wang, Xinhua Liu, Hongyu Zang, Liang Wang   +5 more
doaj   +1 more source

Qualitative Possibilistic Influence Diagrams

, 2008
Influence diagrams (IDs) are one of the most commonly used graphical decision models for reasoning under uncertainty. The quantification of IDs which consists in defining conditional probabilities for chance nodes and utility functions for value nodes is not always obvious.
Wided GuezGuez, Amor, Nahla Ben, Mellouli, Khaled   +2 more
openaire   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Bifurcation dynamics of Sherman neuron under magnetic flow effect

Journal of Measurement Science and Instrumentation, 2023
The bifurcation behavior of Sherman neuron system under the influence of magnetron memristor is analyzed. Taking the membrane potential reversal voltages VCa and VK of islet β-cell neuron model as bifurcation parameters, the inter-spike interval ...
LI Tao, WU Kaijun, ZHENG Huan, YAN Mingjun   +3 more
doaj  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source