Results 131 to 140 of about 3,083,563 (312)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Investigation on status quo of self management of perimenopausal women and its influencing factors

Huli yanjiu, 2016
Objective:To know the status quo of self management of perimenopausal women and its influencing factors.Methods:A total of 417 perimenopausal women were investigated by filling out general situation questionnaire and selfdesigned selfmanagement scale for
LI Hua, WANG Hui
doaj  

Physical fitness status and associated determinants among Chinese children aged 9–12 years in Shandong province: a population-based cross-sectional study

Scientific Reports
Children’s physical fitness is a critical determinant of lifelong health, yet comprehensive investigations into its multi-level influencing factors remain limited, particularly in developing regions.
Wance Wang, Zhihao Huang, Jiahao Gong, Qianqian Li, Guangwen Liu, Renkai Ge   +5 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

INTEREST OF ENTRANCE TO HIGHER EDUCATION FOR CLASS XII STUDENTS OF AUTOMOTIVE AND ELECTRONIC SKILLS PROGRAM AT STATE VOCATIONAL HIGH SCHOOL 1 SEYEGAN [PDF]

, 2011
This study aims to find out the interest of entrance to higher education for Class XII Students of Automotive and Electronic Skills Program at State Vocational High School 1 Seyegan and find out the factors that interest influencing of entrance to higher
Suhirno, Suhirno
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, Volume 20, Issue 6, Page 1429-1452, June 2026.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Exploring thirst incidence and risk factors in patients undergoing general anesthesia after extubation based on ERAS principles: a cross sectional study

BMC Anesthesiology
Background This study aims to comprehend the levels of dry mouth and thirst in patients after general anesthesia, and to identify the factors influencing them. Methods The study included all patients transferred to the Post Anesthesia Care Unit (PACU) at
Zhihe Zeng, Xinge Lu, Ye Sun, Zhaoyang Xiao   +3 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Factors Influencing Breastfeeding in a Hospital Setting [PDF]

, 2010
Breastfeeding is promoted across the globe as the optimum method of infant feeding (World Health Organization, WHO, 2003). Though there is a plethora of published benefits of breastfeeding for baby and mother, breastfeeding rates are below the national ...
Smith, Mary
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, Volume 20, Issue 6, Page 1626-1642, June 2026.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source