Results 1 to 10 of about 1,128,950 (338)

Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic

Nature, 2009
In March and early April 2009, a new swine-origin influenza A (H1N1) virus (S-OIV) emerged in Mexico and the United States. During the first few weeks of surveillance, the virus spread worldwide to 30 countries (as of May 11) by human-to-human ...
Gavin J. D. Smith, Dhanasekaran Vijaykrishna, J. Bahl, S. Lycett, M. Worobey, O. Pybus, Siu-Kit Ma, Chung Lam Cheung, J. Raghwani, S. Bhatt, J. Peiris, Y. Guan, A. Rambaut   +12 more
semanticscholar   +1 more source

Antiviral therapy and prophylaxis of acute respiratory infections

Детские инфекции (Москва), 2016
Thearticle presents the results of years of studies (including biochemical and immunological) of the effectiveness of application and prophylaxis (in relation to nosocomial infections) and the safety of antiviral chemical preparation Arbidol in 694 ...
L. V. Osidak, E. G. Golovacheva, E. A. Dondurey, O. I. Afanasyeva, E. V. Obraztsova, V. P. Drinevsky, E. S. Goncharova, V. F. Suhovetskaya, K. K. Milkint   +8 more
doaj   +1 more source

In vitro activity of human recombinant interferon gamma against SARS-CoV-2 virus

Вопросы вирусологии, 2023
Introduction. The development of drugs against SARS-CoV-2 continues to be crucial for reducing the spread of infection and associated mortality.
Yu. V. Nikolaeva, A. V. Galochkina, A. A. Shtro, S. A. Berns   +3 more
doaj   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents

New England Journal of Medicine, 2018
BACKGROUND Baloxavir marboxil is a selective inhibitor of influenza cap‐dependent endonuclease. It has shown therapeutic activity in preclinical models of influenza A and B virus infections, including strains resistant to current antiviral agents ...
F. Hayden, N. Sugaya, N. Hirotsu, N. Lee, M. D. de Jong, A. Hurt, T. Ishida, H. Sekino, Kota Yamada, S. Portsmouth, K. Kawaguchi, T. Shishido, M. Arai, K. Tsuchiya, T. Uehara, A. Watanabe   +15 more
semanticscholar   +1 more source

Changes in RNA secondary structure affect NS1 protein expression during early stage influenza virus infection

Virology Journal, 2019
RNA secondary structures play a key role in splicing, gene expression, microRNA biogenesis, RNA editing, and other biological processes. The importance of RNA structures has been demonstrated in the life cycle of RNA-containing viruses, including the ...
Irina Baranovskaya, Mariia Sergeeva, Artem Fadeev, Renata Kadirova, Anna Ivanova, Edward Ramsay, Andrey Vasin   +6 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

A Diffusion Approximation for an Epidemic Model [PDF]

, 2006
Influenza is one of the most common and severe diseases worldwide. Devastating epidemics actuated by a new subtype of the influenza A virus occur again and again with the most important example given by the Spanish Flu in 1918/19 with more than 27 ...
Dargatz, Christiane
core   +3 more sources

Influenza and obesity: its odd relationship and the lessons for COVID-19 pandemic

Acta Diabetologica, 2020
Aims Analyze the relationship between obesity and influenza. Methods Basal hormone milieu, defective response of both innate and adaptive immune system and sedentariness are major determinants in the severity of influenza viral infection in obese ...
L. Luzi, M. Radaelli
semanticscholar   +1 more source

Clinical and laboratory presentation of the influenza А (H1N1pdm 2009) in children and adults during the period of 2009-2013 in St. Petersburg

Вопросы вирусологии, 2015
Comparative analysis of the clinical laboratory data from 419 children and 468 adults hospitalized during the pandemic of A (H1N1pdm 2009) and pre- and post-pandemic periods (2010-2013) showed that the clinical presentation of the pandemic influenza in ...
L. V. Osidak, V. V. Gonchar, L. V. Voloshuk, E. G. Golovacheva, N. A. Сulikova, E. A. Dondurey, O. I. Afanasjeva, V. F. Suhovezkaia, K. K. Milkint, E. V. Obraztsova, A. L. Mushkatina, N. I. Konovalova, М. М. Pisareva, Е. S. Goncharova, S. N. Galkina, V. P. Drinevsky, A. Go   +16 more
doaj