Results 91 to 100 of about 8,955,500 (341)

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Enhanced passive surveillance of influenza vaccination in England, 2016−2017– an observational study using an adverse events reporting card

Human Vaccines & Immunotherapeutics, 2019
Influenza is a major public health burden, mainly prevented by vaccination. Recommendations on influenza vaccine composition are updated annually and constant benefit-risk monitoring is therefore needed.
Simon de Lusignan, Filipa Ferreira, Silvia Damaso, Rachel Byford, Sameera Pathirannehelage, Anne Yeakey, Ivelina Yonova, Anne Schuind, Gael Dos Santos   +8 more
doaj   +1 more source

Enhancement of the Influenza Surveillance System in the Russian Federation: the Main Results of the Sentinel Surveillance for Influenza and other Acute Respiratory Viral Infections

Эпидемиология и вакцинопрофилактика, 2017
Existing influenza surveillance system is constantly improved to obtain comprehensive information for understanding of continuously changing situation with the influenza, which is a consequence of the highest variability of the pathogen, its ability to ...
A. A. Sominina, E. A. Smorodintseva, K. A. Stolyarov, A. A. Mel'nikova   +3 more
doaj   +1 more source

Human influenza virus recognition of sialyloligosaccharides [PDF]

FEBS Letters, 1995
Sialic acids are essential components of cell‐surface receptors utilized by influenza viruses. To evaluate the recognition of asialic sugar parts of the receptor, three representative strains of human influenza A and B viruses were tested for their binding of a panel of sialyloligosaccharides.
A.M. Sakharov, N. V. Bovin, Alexander B. Tuzikov, V. E. Piskarev, A.S. Gambaryan, Mikhail Matrosovich, Igor A. Yamskov, Nikolay E. Nifant'ev   +7 more
openaire   +3 more sources

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Antiviral responses by Swine primary bronchoepithelial cells are limited compared to human bronchoepithelial cells following influenza virus infection. [PDF]

PLoS ONE, 2013
Swine generate reassortant influenza viruses because they can be simultaneously infected with avian and human influenza; however, the features that restrict influenza reassortment in swine and human hosts are not fully understood.
Mary J Hauser, Daniel Dlugolenski, Marie R Culhane, David E Wentworth, S Mark Tompkins, Ralph A Tripp   +5 more
doaj   +1 more source

SARS-CoV-2 Variants in Lebanon: Evolution and Current Situation

Biology, 2021
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has seen a worldwide spread since its emergence in 2019, including to Lebanon, where 534,968 confirmed cases (8% of the population) and 7569 deaths have been reported as of 14 May 2021 ...
Nancy Fayad, Walid Abi Habib, Ahmed Kandeil, Rabeh El-Shesheny, Mina Nabil Kamel, Youmna Mourad, Jacques Mokhbat, Ghazi Kayali, Jimi Goldstein, Jad Abdallah   +9 more
doaj   +1 more source

Viral factors in influenza pandemic risk assessment [PDF]

, 2016
The threat of an influenza A virus pandemic stems from continual virus spillovers from reservoir species, a tiny fraction of which spark sustained transmission in humans.
Barclay, Wendy, Beauchemin, Catherine A.A., Bedford, Trevor, Belser, Jessica A., Cobey, Sarah, Friedrich, Thomas C., Handel, Andreas, Herfst, Sander, Kasson, Peter M., Lipsitch, Marc, Lloyd-Smith, James O., Maurer-Stroh, Sebastian, Murcia, Pablo R., Raman, Rahul, Riley, Steven, Roche, Benjamin, Russell, Charles J., Russell, Colin A., Wilke, Claus O.   +18 more
core   +4 more sources

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

Molecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche, Renske Imschoot, Béatrice Lintermans, Lode Denolf, Joachim Taminau, Charlotte Fieuws, Geert Berx, Kris Gevaert, Kathleen B. M. Claes   +8 more
wiley   +1 more source

Incidence and viral aetiologies of acute respiratory illnesses (ARIs) in the United States: a population-based study. [PDF]

, 2016
We conducted prospective, community-wide surveillance for acute respiratory illnesses (ARIs) in Rochester, NY and Marshfield, WI during a 3-month period in winter 2011.
Albertin, C, Blumkin, A, Donahue, JG, Gallivan, S, Lofthus, GK, Schnabel, KC, Shay, DK, Szilagyi, PG, Thompson, MG, Treanor, JJ   +9 more
core   +1 more source