Эпидемиология и вакцинопрофилактика, 2017 Existing influenza surveillance system is constantly improved to obtain comprehensive information for understanding of continuously changing situation with the influenza, which is a consequence of the highest variability of the pathogen, its ability to ...
A. A. Sominina +3 more
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Antiviral responses by Swine primary bronchoepithelial cells are limited compared to human bronchoepithelial cells following influenza virus infection. [PDF]
PLoS ONE, 2013 Swine generate reassortant influenza viruses because they can be simultaneously infected with avian and human influenza; however, the features that restrict influenza reassortment in swine and human hosts are not fully understood.
Mary J Hauser +5 more
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
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Estimating the impact of influenza vaccination and antigenic drift on influenza-related morbidity and mortality in England & Wales using hidden Markov models [PDF]
Influenza causes substantial morbidity and mortality in some influenza sea- sons, especially among the elderly. Influenza seasons dominated by circula- tion of influenza A/H3N2 virus tend to result in more morbidity and mor- tality than seasons ...
Mann, Andrea Gail
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
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African Network for Influenza Surveillance and Epidemiology [PDF]
JID: Influenza in Africa -- Country highlight: Rwanda -- Map of CDC influenza activities -- Calendar of upcoming ...
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Qualitative evaluation of a molecular point-of-care testing study for influenza in UK primary care
BJGP OpenBackground: Influenza contributes to the surge in winter infections and the consequent winter pressures on the health service. Molecular point-of-care testing (POCT) for influenza may improve patient management by providing rapid and accurate clinical ...
Charis Xuan Xie +12 more
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Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
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Evolution of an Eurasian avian-like influenza virus in naïve and vaccinated pigs [PDF]
, 2012 The latest human influenza pandemic highlights the ability of influenza viruses to jump species barriers and emerge in new hosts, as well as the role of pigs in generating viruses with pandemic potential.
Pablo R Murcia +67 more
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Avian Influenza virus glycoproteins restrict virus replication and spread through human airway epithelium at temperatures of the proximal airways. [PDF]
PLoS Pathogens, 2009 Transmission of avian influenza viruses from bird to human is a rare event even though avian influenza viruses infect the ciliated epithelium of human airways in vitro and ex vivo.
Margaret A Scull +7 more
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