Results 201 to 210 of about 325,943 (270)

Transcriptomic Profiling Unveils EDN3+ Meningeal Fibroblasts as Key Players in Sturge‐Weber Syndrome Pathogenesis

Advanced Science, EarlyView.
Sturge‐Weber syndrome (SWS) is characterized by leptomeningeal vascular malformations, leading to seizures and stroke. Analysis of 119 446 brain cells from SWS patients uncovered distinct cell heterogeneity and identified an EDN3⁺ meningeal fibroblast cluster, with WNT5A emerging as a potential key driver of SWS progression and a promising therapeutic ...
Daosheng Ai, Tianyue Ming, Xiaoli Li, Shu Wang, Zhanying Bi, Jinyi Zuo, Zizhang Cheng, Weijin Sun, Mingguo Xie, Fengzhi Li, Xiongfei Wang, Xueling Qi, Guoming Luan, Woo‐ping Ge, Yuguang Guan   +14 more
wiley   +1 more source

Comprehensive Insights into Highly Pathogenic Avian Influenza H5N1 in Dairy Cattle: Transmission Dynamics, Milk-Borne Risks, Public Health Implications, Biosecurity Recommendations, and One Health Strategies for Outbreak Control. [PDF]

Pathogens
Owusu H, Sanad YM.
europepmc   +1 more source

Artesunate Inhibits Neointimal Hyperplasia by Promoting IRF4 Associated Macrophage Polarization

Advanced Science, EarlyView.
This study shows that macrophage interferon regulatory factor 4 (IRF4) improved arterial injury‐induced neointimal hyperplasia by promoting of M2 polarization via up‐regulating krüppel‐like factor 4 (KLF4) in rodent and nonhuman primate models. Notably, artesunate is identified as a potent inducer of IRF4 in macrophages, and proposed as a promising ...
Jinlin Miao, Yule Yong, Zhaohui Zheng, Kui Zhang, Wei Li, Jiayi Liu, Siyi Zhou, Juan‐juan Qin, Haoyang Sun, Yatao Wang, Xianghui Fu, Xing Luo, Siyu Chen, Zhi‐Gang She, Jingjing Cai, Ping Zhu   +15 more
wiley   +1 more source

Antibody function predicts viral control in newborn monkeys immunised with an influenza virus HA stem nanoparticle. [PDF]

Nat Commun
Crofts KF, Holbrook BC, Page CL, Gillespie RA, D'Agostino RB, Sangesland M, Ornelles DA, Kanekiyo M, Alexander-Miller MA.   +8 more
europepmc   +1 more source

Inhibition of Aberrant Activated Fibroblast‐Like Synoviocytes in Rheumatoid Arthritis by Leishmania Peptide via the Regulation of Fatty Acid Synthesis Metabolism

Advanced Science, EarlyView.
LACK156‐173 is internalized into RA‐FLSs via CAPN2‐mediated endocytosis and inhibits the aggressive phenotype of RA‐FLSs by restoring dysregulated fatty acid synthesis metabolism mediated by overexpressed FASN. The findings suggest that targeting the restoration of fatty acid metabolism could potentially alleviate synovial invasion and joint damage in ...
Jianling Su, Xuemei Fan, Yaoyao Zou, Guangtao Fu, Shiqi Feng, Xiaoxue Wang, Yongmei Yu, Lin Li, Zhenhua Bian, Rongrong Huang, Linmang Qin, Jiping Chen, Qin Zeng, Kai Yan, Caiyue Gao, Zhexiong Lian, Xin Li, Yang Li   +17 more
wiley   +1 more source

Impact of COVID-19 on Respiratory Virus Infections in Children, Japan, 2018-2023. [PDF]

Immun Inflamm Dis
Takashita E, Shimizu K, Kawakami C, Momoki T, Saikusa M, Ozawa H, Kumazaki M, Usuku S, Tanaka N, Senda R, Okubo I, Fujisaki S, Nagata S, Morita H, Miura H, Watanabe K, Nakauchi M, Matsuzaki Y, Watanabe S, Hasegawa H, Kawaoka Y.   +20 more
europepmc   +1 more source

Nanotherapy for Neural Retinal Regeneration

Advanced Science, EarlyView.
Nanotechnology enhances ophthalmic treatments by improving drug delivery and regenerating ocular tissues, combating vision loss from retinal diseases through innovative nano‐systems. This review outlines ocular anatomy, pathology, immune microenvironment, and barriers, detailing nanocarrier characteristics, classification, and preparation methods, and ...
Chuyao Yu, Li Dong, Yujia Lv, Xuhan Shi, Ruiheng Zhang, Wenda Zhou, Haotian Wu, Heyan Li, Yitong Li, Zhou Li, Dan Luo, Wen‐Bin Wei   +11 more
wiley   +1 more source

Whole Genome Sequencing and Genetic Diversity of Respiratory Viruses Detected in Children With Acute Respiratory Infections: A One-Year Cross-Sectional Study in Senegal. [PDF]

J Med Virol
Ndiaye AJS, Cortaderona S, Delorme L, Beye M, Kacel I, Bossi V, Lo G, Leye N, Padane A, Diop-Ndiaye H, Kane CT, Diagne NR, Sokhna C, Mboup S, Fournier PE.   +14 more
europepmc   +1 more source

Muscle‐Derived Small Extracellular Vesicles Mediate Exercise‐Induced Cognitive Protection in Chronic Cerebral Hypoperfusion

Advanced Science, EarlyView.
sEVs have a critical role in orchestrating interorgan crosstalk and mediating exercise‐induced therapeutic effects. Lin et al. demonstrates that sEVs miR‐17/20a‐5p mediates the muscle‐brain crosstalk and emphasizes the central role of mTOR signaling in executing molecular programs that can protect brain health in response to exercise. Abstract Physical
Huawei Lin, Lianhua Yin, Weilin Liu, Rui Li, Tao Jiang, Minguang Yang, Yajun Cao, Sinuo Wang, Yan Yu, Cong Chen, Xiaoqin Guo, Wenju Wang, Huanhuan Liu, Yaling Dai, Jiamin Yan, Yanting Lin, Yanyi Ding, Chendong Ruan, Lei Yang, Tiecheng Wu, Jing Tao, Lidan Chen   +21 more
wiley   +1 more source

Recent Advances in Nose and Lung Organoid Models for Respiratory Viral Research. [PDF]

Viruses
Svensson L, Nordgren J, Lundkvist Å, Hagbom M.   +3 more
europepmc   +1 more source