Results 101 to 110 of about 1,229,759 (371)

Barriers of Influenza Vaccination Intention and Behavior – A Systematic Review of Influenza Vaccine Hesitancy, 2005 – 2016

PLoS ONE, 2017
Background Influenza vaccine hesitancy is a significant threat to global efforts to reduce the burden of seasonal and pandemic influenza. Potential barriers of influenza vaccination need to be identified to inform interventions to raise awareness ...
Philipp Schmid, Dorothee Rauber, C. Betsch, Gianni Lidolt, Marie-Luisa Denker   +4 more
semanticscholar   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Clinical and laboratory presentation of the influenza А (H1N1pdm 2009) in children and adults during the period of 2009-2013 in St. Petersburg

Вопросы вирусологии, 2015
Comparative analysis of the clinical laboratory data from 419 children and 468 adults hospitalized during the pandemic of A (H1N1pdm 2009) and pre- and post-pandemic periods (2010-2013) showed that the clinical presentation of the pandemic influenza in ...
L. V. Osidak, V. V. Gonchar, L. V. Voloshuk, E. G. Golovacheva, N. A. Сulikova, E. A. Dondurey, O. I. Afanasjeva, V. F. Suhovezkaia, K. K. Milkint, E. V. Obraztsova, A. L. Mushkatina, N. I. Konovalova, М. М. Pisareva, Е. S. Goncharova, S. N. Galkina, V. P. Drinevsky, A. Go   +16 more
doaj  

Strategies for mitigating an influenza pandemic

Nature, 2006
Development of strategies for mitigating the severity of a new influenza pandemic is now a top global public health priority. Influenza prevention and containment strategies can be considered under the broad categories of antiviral, vaccine and non ...
N. Ferguson, D. Cummings, C. Fraser, James Cajka, P. Cooley, D. Burke   +5 more
semanticscholar   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Respiratory Syncytial Virus Risk Profile in Hospitalized Infants and Comparison with Influenza and COVID-19 Controls in Valladolid, Spain, 2010–2022

Infectious Diseases and Therapy
Introduction We aimed to describe the risk profile of RSV infections among children aged ≤ 24 months in Valladolid from January 2010 to August 2022 and to compare them with influenza and COVID-19 controls.
Mariana Haeberer, Martin Mengel, Rong Fan, Marina Toquero-Asensio, Alejandro Martin-Toribio, Qing Liu, Yongzheng He, Sonal Uppal, Silvia Rojo-Rello, Marta Domínguez-Gil, Cristina Hernán-García, Virginia Fernández-Espinilla, Jessica E. Atwell, Javier Castrodeza Sanz, José M. Eiros, Ivan Sanz-Muñoz   +15 more
doaj   +1 more source

In vitro activity of human recombinant interferon gamma against SARS-CoV-2 virus

Вопросы вирусологии, 2023
Introduction. The development of drugs against SARS-CoV-2 continues to be crucial for reducing the spread of infection and associated mortality.
Yu. V. Nikolaeva, A. V. Galochkina, A. A. Shtro, S. A. Berns   +3 more
doaj   +1 more source

Substitutions near the hemagglutinin receptor-binding site determine the antigenic evolution of influenza A H3N2 viruses in U.S. swine [PDF]

, 2014
Swine influenza A virus is an endemic and economically important pathogen in pigs, with the potential to infect other host species. The hemagglutinin (HA) protein is the primary target of protective immune responses and the major component in swine ...
A. L. Vincent, Anderson, Bao, Bowman, Brown, Centers for Disease Control and Prevention, Core Team R, D. F. Burke, Darriba, De Jong, E. Skepner, Edgar, Feng, Fouchier, Garten, Gauger, Harmon, Hinshaw, Houser, Karasin, Kawaoka, Khurana, Kitikoon, Koel, Lewis, Lindstrom, Lorusso, Loving, Maddison, Miller, Montalvao, Myers, N. S. Lewis, Nelson, Nelson, Nfon, Olsen, P. Kitikoon, Paradis, Pena, Polewicz, PyMOL, Röhm, Salmon, Shinde, Skowronski, Smith, Smith, Stamatakis, T. K. Anderson, Tong, Tong, Vincent, Vincent, Vincent, Vincent, Webby, Webby, Ye   +58 more
core   +1 more source

Parental Hesitancy About Routine Childhood and Influenza Vaccinations: A National Survey

Pediatrics, 2020
In this study, we assessed the prevalence of hesitancy about routine childhood and childhood influenza vaccination among a nationally representative sample of US parents.
A. Kempe, Alison W. Saville, Christina Albertin, G. Zimet, Abigail Breck, L. Helmkamp, S. Vangala, L. Dickinson, Cynthia M. Rand, S. Humiston, P. Szilagyi   +10 more
semanticscholar   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source