Results 141 to 150 of about 1,187,611 (390)

Next-generation influenza vaccines: opportunities and challenges

Nature reviews. Drug discovery, 2020
Seasonal influenza vaccines lack efficacy against drifted or pandemic influenza strains. Developing improved vaccines that elicit broader immunity remains a public health priority.
Chih-Jen Wei, M. Crank, J. Shiver, B. Graham, J. Mascola, G. Nabel   +5 more
semanticscholar   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

PROBLEMS OF ISOLATION, IDENTIFICATION AND ANTIGENIC CHARACTERIZATION OF RECENT HUMAN A(H3N2) INFLUENZA VIRUSES

Вопросы вирусологии, 2018
Human A (H3N2) influenza viruses are distinguished by a high rate of evolution and regularly cause epidemics around the world. Their ability to adapt and to escape from the host's immune response and to change their receptor specificity is very high ...
P. A. Petrova, N. I. Konovalova, D. M. Danilenko, A. D. Vasilieva, M. Yu. Eropkin   +4 more
doaj   +1 more source

Week 1 Influenza Forecast for the 2012-2013 U.S. Season [PDF]

arXiv, 2013
This is part of a series of weekly influenza forecasts made during the 2012-2013 influenza season. Here we present results of forecasts initiated following assimilation of observations for Week 1 (i.e. the forecast begins January 6, 2013) for municipalities in the United States. These forecasts were performed on January 11, 2013. Results from forecasts
arxiv  

Where has all the influenza gone? The impact of COVID-19 on the circulation of influenza and other respiratory viruses, Australia, March to September 2020

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2020
The coronavirus disease pandemic was declared in March 2020, as the southern hemisphere’s winter approached. Australia expected co-circulation of severe acute respiratory syndrome coronavirus 2, influenza and other seasonal respiratory viruses.
S. Sullivan, S. Carlson, Allen Cheng, Monique Chilver, D. Dwyer, Melissa J Irwin, J. Kok, K. Macartney, J. MacLachlan, C. Minney-Smith, David W Smith, N. Stocks, Janette Taylor, I. Barr   +13 more
semanticscholar   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Increasing Herd Immunity with Influenza Revaccination [PDF]

arXiv, 2013
Seasonal influenza is a significant public health concern in the United States and globally. While influenza vaccines are the single most effective intervention to reduce influenza morbidity and mortality, there is considerable debate surrounding the merits and consequences of repeated seasonal vaccination.
arxiv  

Establishment of a diagnostic model to distinguish coronavirus disease 2019 from influenza A based on laboratory findings [PDF]

arXiv, 2020
Background: Coronavirus disease 2019 (COVID-19) and Influenza A are common disease caused by viral infection. The clinical symptoms and transmission routes of the two diseases are similar. However, there are no relevant studies on laboratory diagnostic models to discriminate COVID-19 and influenza A.
arxiv  

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

Incidence of COVID-19 among Vaccinated with Sputnik V and CoviVac Vaccines (Results of the Telephone Survey for the Epidemic Season 2021–2022 in St. Petersburg)

Эпидемиология и вакцинопрофилактика
Relevance. The emergence of a new SARS-COV-2 coronavirus in early 2020 radically changed the seasonal pattern of influenza and other acute respiratory infections worldwide.
M. K. Erofeeva, O. V. Gashinskaya, Zh. V. Buzitskaya, T. G. Zubkova, E. V. Shakhlanskaya, M. A. Stukova, D. A. Lioznov   +6 more
doaj   +1 more source