Results 161 to 170 of about 31,793 (207)
Advanced Materials Technologies, EarlyView.An all‐in‐one microfluidic platform consists of two‐layered PDMS channels integrated with a hydrogel microwell array. This platform enables flow‐driven tumor cell capture, enhanced spheroid formation within the microwells, and advective drug testing. ABSTRACT Effective cancer drug screening requires platforms that replicate the physiological complexity
Omar M. Rahman +2 more
wiley +1 more source
Advanced Materials Technologies, EarlyView.Scalable manufacturing challenges and limited potency remain two of the most intransigent issues limiting clinical translation of EV therapeutics. Mechanical cues can induce phenotypic changes and increased vesiculation in EV source cells without the use of extraneous reagents, chemicals, and/or cargo, thereby potentially drastically improving the ...
Emily H. Powsner +10 more
wiley +1 more source
BLOC: Buildable and Linkable Organ on a Chip
Advanced Materials Technologies, EarlyView.We developed a “Buildable and Linkable Organ on a Chip” (BLOC) that can construct diverse microphysiological systems (MPSs). The BLOC is standardized to the same size and has one of the functions of “Culture,” “Control,” or “Analysis.” Users can freely configure various MPSs, including developing perfusion, cytotoxicity analysis, and biochemical ...
Yusuke Kimura +7 more
wiley +1 more source
An Accessible Microfluidic Platform for the Generation of Polarized Brain Organoids
Advanced Materials Technologies, EarlyView.This study presents an accessible double‐gradient microfluidic device that enables controlled morphogen delivery and spatially polarized differentiation in brain organoids. By integrating a pump‐free design and stable fabrication method, the platform generates dorsal–ventral neuronal asymmetry, offering a reproducible and versatile approach to model ...
Daniel Pérez‐Calixto +6 more
wiley +1 more source
Advanced Materials Technologies, EarlyView.Modeling the blood–brain tumor barrier is challenging due to complex interactions between brain microvasculature and glioma cells. We present two‐photon polymerized 3D micro‐porous capillary‐like structures that support endothelial alignment, cytoskeletal organization, and pericyte‐endothelial‐glioma tri‐cultures.
Nastaran Barin +9 more
wiley +1 more source
Avian influenza and influenza pandemics.
Bulletin of the World Health Organization, 2004 Stefano Lazzari, Klaus Stöhr
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Der Internist, 2021
Influenza is the infectious disease with the highest population-based mortality. It mainly affects those aged 60 years and older, mainly due to immune senescence, which also favors complicated courses and compromises vaccine effectiveness. Therefore, various approaches have been developed for more immunogenic vaccines, which are now available for use ...
Anja, Kwetkat +3 more
openaire +2 more sources
Influenza is the infectious disease with the highest population-based mortality. It mainly affects those aged 60 years and older, mainly due to immune senescence, which also favors complicated courses and compromises vaccine effectiveness. Therefore, various approaches have been developed for more immunogenic vaccines, which are now available for use ...
Anja, Kwetkat +3 more
openaire +2 more sources
Expert Opinion on Pharmacotherapy, 2000
The currently available antiviral drugs rimantadine and amantadine are effective only for influenza A viruses. Another class of influenza antiviral drugs is the neuraminidase inhibitors, which selectively inhibit both influenza A and B viruses. Recent studies have found the neuraminidase inhibitors zanamivir and oseltamivir to be 67-82% effective in ...
M D, Khare, M, Sharland
+7 more sources
The currently available antiviral drugs rimantadine and amantadine are effective only for influenza A viruses. Another class of influenza antiviral drugs is the neuraminidase inhibitors, which selectively inhibit both influenza A and B viruses. Recent studies have found the neuraminidase inhibitors zanamivir and oseltamivir to be 67-82% effective in ...
M D, Khare, M, Sharland
+7 more sources
Infectious Disease Clinics of North America, 1998
Influenza viruses are unique in their ability to cause recurrent epidemics and truly global pandemics during which acute febrile respiratory disease occurs explosively in all age groups. Epidemics of varying severity occur almost annually in temperate climates and are punctuated by the much less frequent but more dramatic occurrence of pandemic ...
Cox, N. J., Fukuda, K.
openaire +4 more sources
Influenza viruses are unique in their ability to cause recurrent epidemics and truly global pandemics during which acute febrile respiratory disease occurs explosively in all age groups. Epidemics of varying severity occur almost annually in temperate climates and are punctuated by the much less frequent but more dramatic occurrence of pandemic ...
Cox, N. J., Fukuda, K.
openaire +4 more sources
DMW - Deutsche Medizinische Wochenschrift, 2013
Yearly epidemics and occasional pandemics with Influenza have been observed for several hundred years. During the last pandemic the reported deaths due to confirmed influenza was lower than expected. New epidemiologic analyses demonstrate that the severity has probably been underestimated. In addition, cohort data from severely ill patients support the
B, Salzberger, W, Jilg
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Yearly epidemics and occasional pandemics with Influenza have been observed for several hundred years. During the last pandemic the reported deaths due to confirmed influenza was lower than expected. New epidemiologic analyses demonstrate that the severity has probably been underestimated. In addition, cohort data from severely ill patients support the
B, Salzberger, W, Jilg
openaire +4 more sources