Results 171 to 180 of about 387,738 (257)

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

A cross-sectional survey of general practitioners' influenza vaccination willingness and influencing factors based on the reasoned action approach. [PDF]

Hum Vaccin Immunother
Ma Y, Li Y, Chen M, Ren J, Xu L.
europepmc   +1 more source

Electroacupuncture Improves the Learning and Memory by Modulating Hippocampal Glucose Metabolism through IGF1/IGF1R Signaling in Alzheimer's Disease

Advanced Science, EarlyView.
Electroacupuncture (EA) ameliorates learning and memory function in 5×FAD mice by regulating the brain glucose metabolic network. This neuroprotective effect is closely related to enhancing neuronal energy utilization via the IGF1/IGF1R signaling pathway.
Shengxiang Liang, Qingqing Zhang, Xiuxiu Wang, Lixin Peng, Xinru Ji, Jiawei Wang, Yusi Zhang, Jiayang Huang, Junchao Yang, Shiqi Zhan, Yiping Xiao, Weilin Liu, Lidian Chen   +12 more
wiley   +1 more source

Intravital Multimodal Imaging of Human Cortical Organoid Transplantation in a Mouse Model of Chronic Stroke

Advanced Science, EarlyView.
A multimodal intravital imaging platform enables longitudinal tracking of human cortical organoids transplanted into chronic stroke lesions. By combining surgical microscopy, MRI, bioluminescence imaging, and two‐photon fluorescence microscopy, the platform captures graft placement, viability dynamics, and cellular‐scale morphology in vivo, offering a ...
Jinghui Wang, Guanda Qiao, Honglin Tan, Colleen Russel, Baixuan Yang, Mengyang Jacky Li, Kexin Wang, Jiadi Xu, Chengyan Chu, Miroslaw Janowski, Tian‐Ming Fu, Piotr Walczak, Yajie Liang   +12 more
wiley   +1 more source

Antiviral Resistance in Influenza: Clinical and Public Health Implications. [PDF]

Influenza Other Respir Viruses
Ngiam JN, Koh MCY, Hayden FG.
europepmc   +1 more source

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

Advanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu, Bingwei Wang, Zhijie Su, Xiaoxv Han, Miao He, Yun Zhao, Yujia Hou, Daotong Li, Weiguang Zhang, Lihua Qin, Ke Wang, Yanchun Li, Yi Yan, Siwang Yu, Xiaoshuai Huang, Tairan Yuwen, Jianyuan Luo, Ruimao Zheng   +17 more
wiley   +1 more source

Influenza Activity and Estimated Vaccine Effectiveness During the 2025-2026 Influenza Season.

JAMA Netw Open
Azziz-Baumgartner E, Budd A, Lee JS, Iuliano AD, Ellington SR, Levine MZ, Zheng XY, Gubareva L, Adams K, DeCuir J, Bozio CH, Reed C, Kirby MK, Rambo-Martin B, Jones JM, Biggerstaff M, Garg S, Davis CT, Shimabukuro TT, Burns E, Kondor R, Olsen SJ, Dugan VG, VISION Coauthors, Irving SA, Naleway AL, Dascomb K, Sheffield T, DeSilva MB, Tartof SY, Sy LS, Klein NP, Zerbo O, Grannis SJ, Dixon BE, Stockwell MS, Stephens AB, Ong TC, Barron MA, Ball SW, Weber ZA, Reeves EL, Ray CS.   +42 more
europepmc   +1 more source

Assessment of human immunity to A/H3N2 influenza subclade K during 2025 emergence. [PDF]

EBioMedicine
Harvey R, Welsh C, Byrne AM, Greenwood D, Stevenson-Leggett P, Galiano M, Bailey D, Chan YW, Boateng J, Wolmuth-Gordon H, Whitaker H, Brown KE, Jeffery-Smith A, Allen A, Amirthanlingam G, Fossum E, Vikse EL, Rohringer A, Hungnes O, Bragstad K, Swanton C, Williams B, Gandhi S, Gamblin S, Carr EJ, Lewis NS, Wall EC, Wu MY, Crick Serology Pipeline, Legacy Investigators.   +29 more
europepmc   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Efficacy and Safety of Kanggan Mixture for Influenza: Protocol for a Multicenter Open-Label Randomized Controlled Trial. [PDF]

JMIR Res Protoc
Gao Y, Ge Y, Wang Q, Sun Z, Dong S, Tang Y, Zhang G, Zhou X, He H.   +8 more
europepmc   +1 more source