Results 81 to 90 of about 1,187,611 (390)

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

In vitro activity of human recombinant interferon gamma against SARS-CoV-2 virus

Вопросы вирусологии, 2023
Introduction. The development of drugs against SARS-CoV-2 continues to be crucial for reducing the spread of infection and associated mortality.
Yu. V. Nikolaeva, A. V. Galochkina, A. A. Shtro, S. A. Berns   +3 more
doaj   +1 more source

Iowa Influenza Surveillance Network Final Report 2006-2008 [PDF]

, 2007
The Iowa Influenza Surveillance Network (IISN) tracks the overall activity, age groups impacted, outbreaks, type and strain, and severity of seasonal influenza. In the 2006-2007 season the network had more than 90 reporting sites that included physicians,

core  

Student-centered interventions the key to student health care worker influenza vaccination [PDF]

, 2016
Objectives: To investigate influenza vaccination uptake rates, attitudes and motivations towards influenza vaccination among student health care workers (HCWs).
Kelly, D, Macey, D, Mak, D, Nyandoro, M
core   +3 more sources

Influenza

Disease-a-Month, 2007
n ...
openaire   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Antiviral therapy and prophylaxis of acute respiratory infections

Детские инфекции (Москва), 2016
Thearticle presents the results of years of studies (including biochemical and immunological) of the effectiveness of application and prophylaxis (in relation to nosocomial infections) and the safety of antiviral chemical preparation Arbidol in 694 ...
L. V. Osidak, E. G. Golovacheva, E. A. Dondurey, O. I. Afanasyeva, E. V. Obraztsova, V. P. Drinevsky, E. S. Goncharova, V. F. Suhovetskaya, K. K. Milkint   +8 more
doaj   +1 more source

Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

Science, 2009
Generation of Swine Flu As the newly emerged influenza virus starts its journey to infect the world's human population, the genetic secrets of the 2009 outbreak of swine influenza A(H1N1) are being revealed.
R. Garten, C. Davis, C. Russell, B. Shu, S. Lindstrom, A. Balish, W. Sessions, Xiyan Xu, E. Skepner, V. Deyde, M. Okomo-Adhiambo, L. Gubareva, J. Barnes, Catherine Bender Smith, S. Emery, M. Hillman, P. Rivailler, James A. Smagala, M. de Graaf, D. Burke, R. Fouchier, C. Pappas, C. Alpuche-Aranda, H. Lopez-Gatell, Hiram Olivera, Irma López, Christopher A. Myers, D. Faix, P. Blair, Cindy Yu, Kimberly M Keene, P. D. Dotson, D. Boxrud, A. Sambol, S. Abid, K. St. George, T. Bannerman, A. Moore, D. J. Stringer, Patricia Blevins, Gail J. Demmler-Harrison, M. Ginsberg, P. Kriner, S. Waterman, S. Smole, H. Guevara, E. Belongia, P. A. Clark, S. Beatrice, R. Donis, J. Katz, L. Finelli, C. Bridges, M. Shaw, D. Jernigan, T. Uyeki, Derek J. Smith, A. Klimov, N. Cox   +58 more
semanticscholar   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Moving epidemic method (MEM) applied to virology data as a novel real time tool to predict peak in seasonal influenza healthcare utilisation. The Scottish experience of the 2017/18 season to date [PDF]

, 2018
Scotland observed an unusual influenza A(H3N2)- dominated 2017/18 influenza season with healthcare services under significant pressure. We report the application of the moving epidemic method (MEM) to virology data as a tool to predict the influenza ...
Bishop, Jennifer, Cameron, Ross L., Marques, Diogo F.P., McMenamin, Jim, Murray, Josephine L.K., Potts, Alison, Reynolds, Arlene J., Robertson, Chris, von Wissmann, Beatrix, William, Naoma   +9 more
core   +2 more sources