Results 111 to 120 of about 138,269 (246)
Pharmacy‐Based Immunization Delivery: A Comprehensive History and Current Challenges
ABSTRACT Pharmacists and their teams have a long history of involvement with vaccines. This paper describes the contributions of pharmacy‐based immunization delivery in the United States from the 1800's to date. Early activities centered around storage and distribution of antitoxins and vaccines. From the 1950s through the early 1990s, pharmacists were
Jean‐Venable R. Goode +4 more
wiley +1 more source
Organoids: From Bench to Bedside Applications
Organoids, as a groundbreaking biomedical research platform, utilize adult stem cells (ASCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) as sources. By integrating specific growth and differentiation signals within an extracellular matrix (e.g., Matrigel), organoids guide cells to self‐assemble into three‐dimensional ...
Kelin Li +6 more
wiley +1 more source
This systematic review synthesizes global evidence on the integration of One Health into national health systems. It identifies key system‐level barriers, including governance fragmentation, financing constraints, workforce limitations, and policy gaps, alongside emerging opportunities such as institutional support and multisectoral collaboration.
Md. Shahidul Islam +2 more
wiley +1 more source
ABSTRACT Introduction Swine may act as ‘epidemiological bridges’ and reservoirs for the emergence of novel zoonotic influenza viruses with pandemic potential. While bidirectional exchange of influenza A viruses at the swine–human interface is well recognised, data on the extent of interspecies transmission are limited.
Solveig Jore +7 more
wiley +1 more source
MVP Inhibits Influenza A Virus‐Induced Ferroptosis by Targeting IRF1 and Increasing FSP1 Activity
During IAV infection, MVP inhibits IRF1 polyubiquitination, thereby relieving IRF1‐mediated transcriptional inhibition of FSP1. Consequently, this leads to an upregulation of FSP1 expression, thereby reinforcing the inhibition of ferroptosis. In addition, the MVP can promote myristoylation and ubiquitination of FSP1, enabling its membrane localization ...
Yingbo Chen +12 more
wiley +1 more source
Increased Numbers of CD4+ T‐Cells in the Hypocretin/Orexin Region of Narcolepsy Type 1
Narcolepsy type 1 (NT1) is presumed to be an autoimmune disorder caused by hypothalamic loss of hypocretin (Hcrt; orexin). In postmortem NT1 brains, we observed an 11‐fold increase of CD4+ T‐cells in the Hcrt region compared with control hypothalami, without a corresponding rise in CD8+ T‐cells.
Ling Shan +5 more
wiley +1 more source
The Effect of Voluntary Staying at Home on Japanese Female Suicide During the COVID‐19 Pandemic
ABSTRACT In Japan, female suicide increased during the COVID‐19 pandemic. This study evaluated how pandemic‐related home confinement affected female suicide. We employed a shift‐share instrumental variable design to assess whether differential exposure to the pandemic caused changes in suicide incidence.
Yoko Ibuka +3 more
wiley +1 more source
Whispers of Pathogens; Social Contagion in Infectious Disease Dynamics: A Review
ABSTRACT Background and Aims Infectious disease dynamics are deeply intertwined with social structures, behaviors, and information systems. This narrative review examines how social factors conceptualized through the integrated lens of “social contagion” within a syndemic framework shape infectious disease patterns from January 2000 to January 2024 ...
Sayed Mortaza Fayez
wiley +1 more source
ABSTRACT Background With the re‐emergence of monkeypox (Mpox), it is vital for communities to assess and effectively respond to emerging outbreaks. This paper aims to review the potential of clade I Mpox to result in a widespread outbreak by assessing genetically enhanced virulence, transmission, and clinical manifestations.
Md. Ashrafur Rahman +5 more
wiley +1 more source
Vaccination Coverage Against Coronavirus Disease 2019 (COVID‐19) in Brazil's Indigenous Population
ABSTRACT Indigenous populations in Brazil were prioritized for coronavirus disease 2019 (COVID‐19) vaccination due to their increased vulnerability. The aim of the study was to describe COVID‐19 vaccination coverage among Indigenous population across Brazilian regions and Special Indigenous Health Districts (DSEIs; acronym for Distritos Sanitários ...
Nathália Mariana Santos Sansone +5 more
wiley +1 more source

