Results 281 to 290 of about 3,100,016 (354)

A Simple and Efficient Stereoselective Synthesis of a 2,3‐Difluorosialic Acid‐Based Influenza Virus Neuraminidase Inhibitor

open access: yesChemistry – A European Journal, Volume 31, Issue 16, March 17, 2025.
A new simple approach for the exquisitely stereo‐controlled introduction of the C‐3 equatorial fluorine on neuraminic acid derivatives by incorporation of steric bulk at C‐4. Through this size‐controlled method, we have elaborated a novel synthetic route that exclusively produces the potent anti‐influenza drug candidate; 2,3‐difluoro‐zanamivir analogue
Ibrahim M. El‐Deeb, Mark von Itzstein
wiley   +1 more source

Recent Cutting‐Edge Technologies for the Delivery of Peptide Nucleic Acid

open access: yesChemistry – A European Journal, EarlyView.
This review provides an overview of PNA cellular delivery methods, starting with traditional peptide‐based systems and progressing to advanced approaches using nanoparticles, liposomes, and calixarene. It highlights how these innovative strategies have opened the way for more effective and efficient PNA delivery, ultimately enhancing the potential for ...
Concetta Avitabile   +4 more
wiley   +1 more source

Influenza A virus rapidly adapts particle shape to environmental pressures. [PDF]

open access: yesNat Microbiol
Partlow EA   +5 more
europepmc   +1 more source

Lewis‐X‐Containing Triterpenoid Saponins Inhibit DC‐SIGN‐ and L‐SIGN‐Mediated Transfer of HIV‐1 Infection

open access: yesChemistry – A European Journal, EarlyView.
The convergent synthesis of Lewis‐X‐containing betulinic acid and echinocystic acid saponins (1 and 2) is presented. The synthetic saponins were shown to inhibit, at the low micromolar range, the DC‐SIGN‐ and L‐SIGN‐mediated transfer of HIV‐1 infection to CD4‐positive cells, whereas free Lewis‐X, aglycones, and structurally similar triterpenoid ...
Oscar Javier Gamboa Marin   +5 more
wiley   +1 more source

Influenza A hemagglutinin virus-like particles confer protection against influenza B virus infection. [PDF]

open access: yesEmerg Microbes Infect
Mao J   +7 more
europepmc   +1 more source

A truncation mutant of adenomatous polyposis coli impairs apical cell extrusion through elevated epithelial tissue tension

open access: yesCytoskeleton, EarlyView.
Abstract Tissue tension encompasses the mechanical forces exerted on solid tissues within animal bodies, originating from various sources such as cellular contractility, interactions with neighboring cells and the extracellular matrix. Emerging evidence indicates that an imbalance in such forces can influence structural organization, homeostasis, and ...
Wan J. Gan   +7 more
wiley   +1 more source

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