Results 301 to 310 of about 945,008 (390)

Targeted NanoBiT Screening Identifies a Novel Interaction Between SNAPIN and Influenza A Virus M1 Protein. [PDF]

Biology (Basel)
Zhang X, Wang H, Zhao C, Shi W, Wen F, Qiang H, Liu S, Li P, Chen X, Zhang C, Huang J, Wang Y, Zhang Z, Ma S.   +13 more
europepmc   +1 more source

Forsythoside E Alleviates Liver Injury by Targeting PKM2 Tetramerization to Promote Macrophage M2 Polarization

Advanced Science, EarlyView.
Here, the study shows for the first time that Forsythoside E (FE) can promote PKM2 tetramerization by binding to its K311 site. Furthermore, it induces metabolic reprogramming of macrophages and inhibits NLRP3 expression. Finally, it can alleviate sepsis‐induced liver injury by promoting M2 anti‐inflammatory polarization.
Bingxin Wu, Xuechun Yu, Yanling Li, Lin An, Rongrong Zhang, Rong Zhang, Fan Zhang, Zhongqiu Liu, Caiyan Wang   +8 more
wiley   +1 more source

Matrix protein 1 (M1) of influenza A virus: structural and functional insights. [PDF]

Emerg Microbes Infect
Zhu Y, Sun Y, Deng X, Cao P, Li S, Yu H, Sheng S, Cong Y, Cong Y.   +8 more
europepmc   +1 more source

Autocrine Netrin‐1 Signaling in Hepatic Stellate Cells Drives Liver Fibrosis and Diet‐Induced Metabolic Dysfunction‐Associated Steatohepatitis in Mice

Advanced Science, EarlyView.
Netrin‐1 expression is upregulated in hepatic stellate cells (HSCs) during metabolic dysfunction–associated steatohepatitis and injury‐mediated liver fibrosis. Secreted Netrin‐1 establishes an autocrine positive feedback loop by binding to UNC5B receptors on HSCs.
Jiahui Zhao, Yajie Peng, Hongyan Lei, Tianyi Wang, Huajuan Wang, Bo Wang, Jin Li, Xiaoying Li, Xuelian Xiong   +8 more
wiley   +1 more source

The (digestive) path less traveled: influenza A virus and the gastrointestinal tract. [PDF]

mBio
Bullock TA, Pappas C, Uyeki TM, Brock N, Kieran TJ, Olsen SJ, Davis TC, Tumpey TM, Maines TR, Belser JA.   +9 more
europepmc   +1 more source

Impact of the polymerase acidic protein E199K substitution in influenza A viruses on baloxavir susceptibility

Emi Takashita, Yoshihiro Yasui, Asaka Ikegaya, Kanju Saka, Noriyuki Maeshiro, Hiroko Morita, Shiho Nagata, Seiichiro Fujisaki, Hideka Miura, Noriko Kishida, Kazuya Nakamura, Masayuki Shirakura, Shinji Watanabe, Hideki Hasegawa, Kazuya Mitsuhashi, Asami Ohnishi, Tomoko Takahashi, Yuko Suzuki, Minako Ato, Youko Fujiya, Naomi Ogawa, Nozomi Saito, Miyako Kon, Ayari Ikeda, Asaka Okubo, Yuki Wakabayashi, Akira Wakatsuki, Rina Kubota, Yoshiyuki Makino, Yasuo Kaburagi, Hitomi Yahata, Tomofumi Seno, Mami Nagashima, Kohei Shimizu, Chie Akaboshi, Yumiko Nagasawa, Kaori Imura, Miho Kitazume, Michiko Takeuchi, Erina Miyajima, Isako Onoda, Hirosato Ehara, Ryota Akaike, Takahisa Shimada, Nao Kobashi, Nobushige Sakai, Masahiro Nishioka, Yusuke Sato, Masakazu Suzuki, Takuya Yano, Asa Tanino, Kazuko Nakagawa, Saeko Morikawa, Hideki Mizutani, Tomohiro Oshibe, Ai Mori, Saya Yamamoto, Shiho Nagase, Yutaka Ueda, Yurie Kanba, Manabu Ishii, Yukie Shimazu, Yasutsugu Kawahara, Mitsuhiro Kameyama, Mizuki Yamamoto, Yukari Tsuchida, Sayako Yoshida, Wataru Satou, Yuri Kondo, Michihiko Miyamoto, Sonoko Izumida, Ukyo Osoegawa, Yumika Takaki, Mayumi Kadoguchi, Minoru Ikeda, Nami Tsuru   +75 more
openalex   +1 more source

Avian Influenza A Virus [PDF]

, 2020
openaire   +1 more source

GlycoChat Uncovers Glycan–Lectin Circuits in the Tumor Microenvironment of Pancreatic Cancer

Advanced Science, EarlyView.
Aberrant glycosylation drives cancer progression, yet its role in the tumor microenvironment remains unclear. We developed GlycoChat to map glycan–lectin circuits at single‐cell resolution. We discovered that cancer cells induce immunosuppressive macrophage differentiation and impair phagocytosis through interactions with CLEC10A and SIGLEC3 ...
Dinh Xuan Tuan Anh, Sunanda Keisham, Arun Burramsetty, Lalhaba Oinam, Koichiro Kumano, Akihiro Kuno, Osamu Shimomura, Tatsuya Oda, Hiroaki Tateno   +8 more
wiley   +1 more source

Development of a Combined Clinical and Research-Developed Testing Strategy for Highly Pathogenic Avian Influenza A Virus H5. [PDF]

Open Forum Infect Dis
Adams GC, Devlin JE, Klontz E, Laing RA, Branda JA, Chowdhury N, Kwon S, Sabeti PC, Stachler E, Thiriveedhi V, Shenoy ES, Lemieux JE, Turbett SE.   +12 more
europepmc   +1 more source

Parallel Genome‐Wide CRISPR Screens Reveal SORL1 and ZFYVE19 as Sequential Host Determinants of Salmonella Infection

Advanced Science, EarlyView.
To distinguish how Salmonella invades cells vs how it survives long‐term, a parallel CRISPR screening platform is developed. This approach reveals the host proteins that the bacterium exploits at different stages of infection. The study identifies SORL1 as a novel host factor for invasion and demonstrates that blocking it with an antibody effectively ...
Sehee Yun, Seoyeon Kim, Seonggyu Kim, Minsoo Noh, Dae‐Kyum Kim, Eun‐Jin Lee, Hunsang Lee   +6 more
wiley   +1 more source