Results 51 to 60 of about 947,263 (392)

Direct RNA Sequencing of the Coding Complete Influenza A Virus Genome

Scientific Reports, 2018
For the first time, a coding complete genome of an RNA virus has been sequenced in its original form. Previously, RNA was sequenced by the chemical degradation of radiolabeled RNA, a difficult method that produced only short sequences.
Matthew W. Keller, Benjamin L. Rambo-Martin, Malania M. Wilson, Callie A. Ridenour, Samuel S. Shepard, T. Stark, Elizabeth B. Neuhaus, V. Dugan, D. Wentworth, J. Barnes   +9 more
semanticscholar   +1 more source

Influenza A virus uncoating [PDF]

, 2020
Influenza A virus (IAV) is an enveloped virus of the Orthomyxoviridae with a negative-sense single-stranded RNA genome. During virus cell entry, viral and cellular cues are delivered in a stepwise manner within two distinct cellular compartments-the endosomes and the cytosol.
openaire   +4 more sources

Substitutions near the hemagglutinin receptor-binding site determine the antigenic evolution of influenza A H3N2 viruses in U.S. swine [PDF]

, 2014
Swine influenza A virus is an endemic and economically important pathogen in pigs, with the potential to infect other host species. The hemagglutinin (HA) protein is the primary target of protective immune responses and the major component in swine ...
A. L. Vincent, Anderson, Bao, Bowman, Brown, Centers for Disease Control and Prevention, Core Team R, D. F. Burke, Darriba, De Jong, E. Skepner, Edgar, Feng, Fouchier, Garten, Gauger, Harmon, Hinshaw, Houser, Karasin, Kawaoka, Khurana, Kitikoon, Koel, Lewis, Lindstrom, Lorusso, Loving, Maddison, Miller, Montalvao, Myers, N. S. Lewis, Nelson, Nelson, Nfon, Olsen, P. Kitikoon, Paradis, Pena, Polewicz, PyMOL, Röhm, Salmon, Shinde, Skowronski, Smith, Smith, Stamatakis, T. K. Anderson, Tong, Tong, Vincent, Vincent, Vincent, Vincent, Webby, Webby, Ye   +58 more
core   +1 more source

Human-Origin Influenza A(H3N2) Reassortant Viruses in Swine, Southeast Mexico

Emerging Infectious Diseases, 2019
The genetic diversity of influenza A viruses circulating in swine in Mexico complicates control efforts in animals and presents a threat to humans, as shown by influenza A(H1N1)pdm09 virus. To describe evolution of swine influenza A viruses in Mexico and
Martha I. Nelson, Carine K. Souza, Nídia S. Trovão, Andres Diaz, Ignacio Mena, Albert Rovira, Amy L. Vincent, Montserrat Torremorell, Douglas Marthaler, Marie R. Culhane   +9 more
doaj   +1 more source

Influenza A virus ribonucleoproteins form liquid organelles at endoplasmic reticulum exit sites

Nature Communications, 2018
Influenza A virus has an eight-partite RNA genome that during viral assembly forms a complex containing one copy of each RNA. Genome assembly is a selective process driven by RNA-RNA interactions and is hypothesized to lead to discrete punctate ...
Marta Alenquer, Sílvia Vale-Costa, T. Etibor, Filipe Ferreira, A. L. Sousa, M. Amorim   +5 more
semanticscholar   +1 more source

Influenza pathogenesis: mechanisms of modulation by agent proteins

Журнал инфектологии, 2015
Modern concepts of the influence of the proteins from viruses-etiological agents of flu – Influenzavirus A, B and C (Orthomyxoviridae) – on the development of different elements of the main disease pathogenesis are analyzed in the review.
M. Yu. Shchelkanov, A. F. Popov, A. I. Simakova, I. V. Zenin, E. S. Proshina, I. M. Kirillov, K. A. Dmitrenko, D. V. Shevchuk   +7 more
doaj   +1 more source

Drug resistance in influenza A virus: the epidemiology and management

Infection and Drug Resistance, 2017
Influenza A virus (IAV) is the sole cause of the unpredictable influenza pandemics and deadly zoonotic outbreaks and constitutes at least half of the cause of regular annual influenza epidemics in humans.
M. Hussain, Henry D. Galvin, T. Haw, Ashley N Nutsford, M. Husain   +4 more
semanticscholar   +1 more source

STUDIES ON THE VIRUS OF INFLUENZA [PDF]

Journal of Experimental Medicine, 1936
1. Evidence is presented indicating the presence of a filtrable virus in the nasopharyngeal secretions of individuals suffering from influenza. 2. An attempt to transfer influenza from one human being to another by means of filtered nasopharyngeal washings resulted in the production in the inoculated volunteer of a common cold.
Katherine C. Mills, A. R. Dochez, Yale Kneeland   +2 more
openaire   +3 more sources

Canalization of the evolutionary trajectory of the human influenza virus [PDF]

, 2011
Since its emergence in 1968, influenza A (H3N2) has evolved extensively in genotype and antigenic phenotype. Antigenic evolution occurs in the context of a two-dimensional 'antigenic map', while genetic evolution shows a characteristic ladder-like ...
A Kucharski, A Monto, A Park, A Rambaut, Andrew Rambaut, B Adams, B Finkelman, C Viboud, CA Russell, D Weinreich, DJ Smith, E Goldstein, E O'Dea, E Volz, F Carrat, F Tria, G Chowell, G Hirst, IG Barr, J Gog, J Lin, J O'Brien, J Truscott, J Voeten, K Koelle, K Koelle, K Koelle, K Koelle, M Recker, Mercedes Pascual, MI Nelson, NM Ferguson, R Bush, S Bhatt, S Gould, S Kryazhimskiy, S Park, T Bedford, T Bedford, Trevor Bedford, V Gupta, WM Fitch, YI Wolf, Z Yang   +43 more
core   +5 more sources

Multicenter Evaluation of the QIAstat-Dx Respiratory Panel for the Detection of Viruses and Bacteria in Nasopharyngeal Swab Specimens [PDF]

, 2020
The QIAstat-Dx Respiratory Panel (QIAstat-Dx RP) is a multiplex in vitro diagnostic test for the qualitative detection of 20 pathogens directly from nasopharyngeal swab (NPS) specimens. The assay is performed using a simple sample-to-answer platform with
Granato, Paul, Hannet, Irene, Hansen, Glen, Leber, Amy L., Lisby, Jan Gorm, Pareja, Josep, Relich, Ryan F., Schneider, Uffe Vest, Young, Stephen   +8 more
core   +1 more source