Results 81 to 90 of about 945,008 (390)

Persistent Leukoencephalopathy Following H1N1 Infection Associated With a Novel MYRF Variant (p.Gly735Asp)

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Mutations in myelin regulatory factor (MYRF) are linked to demyelinating disorders. We report a 38‐year‐old male who developed acute symmetric leukoencephalopathy mimicking a stroke following an influenza A virus infection. While clinical symptoms markedly improved with corticosteroids, MRI revealed persistent white matter lesions, contrasting
Jinghan Hu, Leiyun Huang, Wan Zhu, Min Peng, Qiang Gong, Jing Qian   +5 more
wiley   +1 more source

Evaluation of recombinant influenza virus-simian immunodeficiency virus vaccines in macaques [PDF]

, 2009
There is an urgent need for human immunodeficiency virus (HIV) vaccines that induce robust mucosal immunity. Influenza A viruses (both H1N1 and H3N2) were engineered to express simian immunodeficiency virus (SIV) CD8 T-cell epitopes and evaluated ...
Alcantara, Sheilajen, De Rose, Robert, Doherty, Peter C., Hurt, Aeron, Kent, Stephen J., Laurie, Karen, Loh, Liyen, Moffat, Jessica M., Reece, Jeanette C., Sexton, Amy, Stambas, John, Turner, Stephen J.   +11 more
core   +2 more sources

Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition

Scientific Reports, 2016
The inflammasome NLRP3 is activated by pathogen associated molecular patterns (PAMPs) during infection, including RNA and proteins from influenza A virus (IAV).
M. Tate, James D. H. Ong, J. Dowling, J. McAuley, A. Robertson, E. Latz, G. Drummond, M. Cooper, P. Hertzog, A. Mansell   +9 more
semanticscholar   +1 more source

FeDSNP‐Pa Nanoassemblies: A Triple‐Action Therapeutic Strategy Targeting Oxidative Stress, Inflammation, and Pyroptosis for Retinal Ganglion Cell Protection in Glaucoma

Advanced Functional Materials, EarlyView.
FeDSNP‐Pa, a metallized nanoparticle loaded with sodium pyruvate (Pa), exerts triple therapeutic effects by scavenging reactive oxygen species (ROS), suppressing inflammatory responses, and inhibiting pyroptosis signaling pathways. This multifunctional neuroprotective strategy protecting retinal ganglion cells (RGCs) from elevated intraocular pressure ...
Yukun Wu, Xue Li, Tong Wu, Dan Ji, Yugang Bai, Xuezhi Zhou   +5 more
wiley   +1 more source

Influenza virus in human exhaled breath: an observational study. [PDF]

PLoS ONE, 2008
Recent studies suggest that humans exhale fine particles during tidal breathing but little is known of their composition, particularly during infection.We conducted a study of influenza infected patients to characterize influenza virus and particle ...
Patricia Fabian, James J McDevitt, Wesley H DeHaan, Rita O P Fung, Benjamin J Cowling, Kwok Hung Chan, Gabriel M Leung, Donald K Milton   +7 more
doaj   +1 more source

Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus

Proceedings of the National Academy of Sciences of the United States of America, 2016
Significance In addition to neutralizing antigens, antibodies are also capable of stimulating cellular responses through Fc–Fc receptor interactions.
Wenqian He, G. Tan, Caitlin E. Mullarkey, Amanda J. Lee, M. Lam, F. Krammer, Carole J Henry, P. Wilson, A. Ashkar, P. Palese, Matthew S. Miller   +10 more
semanticscholar   +1 more source

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

Use of National Pneumonia Surveillance to Describe Influenza A(H7N9) Virus Epidemiology, China, 2004–2013

Emerging Infectious Diseases, 2013
In mainland China, most avian influenza A(H7N9) cases in the spring of 2013 were reported through the pneumonia of unknown etiology (PUE) surveillance system.
Nijuan Xiang, Fiona Havers, Tao Chen, Ying Song, Wenxiao Tu, Leilei Li, Yang Cao, Bo Liu, Lei Zhou, Ling Meng, Zhiheng Hong, Rui Wang, Yan Niu, Jianyi Yao, Kaiju Liao, Lianmei Jin, Yanping Zhang, Qun Li, Marc-Alain Widdowson, Zijian Feng   +19 more
doaj   +1 more source

Viral factors in influenza pandemic risk assessment [PDF]

, 2016
The threat of an influenza A virus pandemic stems from continual virus spillovers from reservoir species, a tiny fraction of which spark sustained transmission in humans.
Barclay, Wendy, Beauchemin, Catherine A.A., Bedford, Trevor, Belser, Jessica A., Cobey, Sarah, Friedrich, Thomas C., Handel, Andreas, Herfst, Sander, Kasson, Peter M., Lipsitch, Marc, Lloyd-Smith, James O., Maurer-Stroh, Sebastian, Murcia, Pablo R., Raman, Rahul, Riley, Steven, Roche, Benjamin, Russell, Charles J., Russell, Colin A., Wilke, Claus O.   +18 more
core   +4 more sources

Giant Magnetoresistance-based Biosensor for Detection of Influenza A Virus

Frontiers in Microbiology, 2016
We have developed a simple and sensitive method for the detection of influenza A virus based on giant magnetoresistance (GMR) biosensor. This assay employs monoclonal antibodies to viral nucleoprotein (NP) in combination with magnetic nanoparticles (MNPs)
V. Krishna, Kai Wu, Andrés Perez, Jianping Wang   +3 more
semanticscholar   +1 more source