Results 91 to 100 of about 928,120 (339)
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Virology Journal, 2023 Background Influenza A viruses have undergone rapid evolution with virulent; however, complete and comprehensive data on gene evolution and amino acid variation of HA and NA in immunosuppressed patients was few.
Yafen Liu +8 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2016 Significance In addition to neutralizing antigens, antibodies are also capable of stimulating cellular responses through Fc–Fc receptor interactions.
Wenqian He +10 more
semanticscholar +1 more source
Favipiravir, an anti-influenza drug against life-threatening RNA virus infections
Pharmacology and Therapeutics, 2020 Favipiravir has been developed as an anti-influenza drug and licensed as an anti-influenza drug in Japan. Additionally, favipiravir is being stockpiled for 2 million people as a countermeasure for novel influenza strains.
K. Shiraki, T. Daikoku
semanticscholar +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Results of Epidemiological Monitoring Bird Flu in Kyrgyz Republic
Эпидемиология и вакцинопрофилактика, 2016 The results of the study with modern molecular genetic research methods the circulation in the Kyrgyzstan territory avian flu virus in waterfowl and humans.
K. T. Kasymbekova +3 more
doaj +1 more source
Monomeric Nucleoprotein of Influenza A Virus
PLoS Pathogens, 2013 Isolated influenza A virus nucleoprotein exists in an equilibrium between monomers and trimers. Samples containing only monomers or only trimers can be stabilized by respectively low and high salt. The trimers bind RNA with high affinity but remain trimmers, whereas the monomers polymerise onto RNA forming nucleoprotein-RNA complexes.
Chenavas, Sylvie +8 more
openaire +9 more sources
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
BMC Infectious Diseases, 2019 Background Influenza is a global infectious disease with a large burden of illness and high healthcare costs. Those who experience greater burden of disease include younger and older people, and pregnant women.
Kam Cheong Wong +2 more
doaj +1 more source
An unbiased genetic screen reveals the polygenic nature of the influenza virus anti-interferon response. [PDF]
, 2014 Influenza A viruses counteract the cellular innate immune response at several steps, including blocking RIG I-dependent activation of interferon (IFN) transcription, interferon (IFN)-dependent upregulation of IFN-stimulated genes (ISGs), and the activity
Asensio, VJ +7 more
core +2 more sources