Results 1 to 10 of about 9,717 (178)

Comparative Pathogenicity and Transmissibility of the H7N9 Highly Pathogenic Avian Influenza Virus and the H7N9 Low Pathogenic Avian Influenza Virus in Chickens [PDF]

Viruses, 2019
There were five outbreaks of H7N9 influenza virus in humans in China since it emerged in 2013, infecting >1000 people. The H7N9 low pathogenic influenza virus was inserted into four amino acids in the HA protein cleavage site to mutate into the H7N9 ...
Hao Yu, Kunpeng Zhang, Xumeng Ye, Wenqing Wang, Wenbo Wu, Xia Wang, Yun Guan, Zhuoliang He, Yong Wang, Peirong Jiao   +9 more
doaj   +5 more sources

Pathogenicity of the Novel A/H7N9 Influenza Virus in Mice [PDF]

mBio, 2013
A novel avian-origin influenza A/H7N9 virus infecting humans was first identified in March 2013 and, as of 30 May 2013, has caused 132 human infections leading to 33 deaths.
Chris Ka Pun Mok, Horace Hok Yeung Lee, Michael Chi Wai Chan, Sin Fun Sia, Maxime Lestra, John Malcolm Nicholls, Huachen Zhu, Yi Guan, Joseph Malik Sriyal Peiris   +8 more
doaj   +5 more sources

Pathogenesis of Influenza A(H7N9) Virus in Aged Nonhuman Primates. [PDF]

J Infect Dis, 2020
Abstract The avian influenza A(H7N9) virus has caused high mortality rates in humans, especially in the elderly; however, little is known about the mechanistic basis for this. In the current study, we used nonhuman primates to evaluate the effect of aging on the pathogenicity of A(H7N9) virus.
Fukuyama S, Iwatsuki-Horimoto K, Kiso M, Nakajima N, Gregg RW, Katsura H, Tomita Y, Maemura T, da Silva Lopes TJ, Watanabe T, Shoemaker JE, Hasegawa H, Yamayoshi S, Kawaoka Y.   +13 more
europepmc   +4 more sources

Biological features of novel avian influenza A (H7N9) virus [PDF]

Nature, 2013
Human infection associated with a novel reassortant avian influenza H7N9 virus has recently been identified in China. A total of 132 confirmed cases and 39 deaths have been reported. Most patients presented with severe pneumonia and acute respiratory distress syndrome.
Jie Dong, George Fu Gao, Dayan Wang
exaly   +3 more sources

Identifying key bird species and geographical hotspots of avian influenza A (H7N9) virus in China [PDF]

Infectious Diseases of Poverty, 2018
Background In China since the first human infection of avian influenza A (H7N9) virus was identified in 2013, it has caused serious public health concerns due to its wide spread and high mortality rate.
Benyun Shi, Xiao-Ming Zhan, Jin-Xin Zheng, Hongjun Qiu, Dan Liang, Yan-Ming Ye, Guo-Jing Yang, Yang Liu, Jiming Liu   +8 more
doaj   +2 more sources

Evolution and Antigenic Differentiation of Avian Influenza A(H7N9) Virus, China. [PDF]

Emerg Infect Dis
We characterized the evolution and molecular characteristics of avian influenza A(H7N9) viruses isolated in China during 2021-2023. We systematically analyzed the 10-year evolution of the hemagglutinin gene to determine the evolutionary branch. Our results showed recent antigenic drift, providing crucial clues for updating the H7N9 vaccine and disease ...
Liu Y, Chen Y, Yang Z, Lin Y, Fu S, Chen J, Xu L, Liu T, Niu B, Huang Q, Liu H, Zheng C, Liao M, Jia W.   +13 more
europepmc   +4 more sources

Role of Neuraminidase in Influenza A(H7N9) Virus Receptor Binding. [PDF]

J Virol, 2017
ABSTRACT Influenza A(H7N9) viruses have caused a large number of zoonotic infections since their emergence in 2013. They remain a public health concern due to the repeated high levels of infection with these viruses and their perceived pandemic potential.
Benton DJ, Wharton SA, Martin SR, McCauley JW.   +3 more
europepmc   +3 more sources

Enhanced Replication of Highly Pathogenic Influenza A(H7N9) Virus in Humans. [PDF]

Emerg Infect Dis, 2018
Para aclarar la amenaza planteada por la aparición de la infección por el virus de la influenza A(H7N9) altamente patógena entre los humanos, caracterizamos el complejo de polimerasa viral. La polimerasa básica 2-482R, la polimerasa básica 2-588V y la polimerasa ácida-497R mejoraron individual o aditivamente la actividad de la polimerasa del virus, lo ...
Yamayoshi S, Kiso M, Yasuhara A, Ito M, Shu Y, Kawaoka Y.   +5 more
europepmc   +5 more sources

Entry properties and entry inhibitors of a human H7N9 influenza virus. [PDF]

PLoS ONE, 2014
The recently identified human infections with a novel avian influenza H7N9 virus in China raise important questions regarding possible risk to humans. However, the entry properties and tropism of this H7N9 virus were poorly understood.
Youhui Si, Jianguo Li, Yuqiang Niu, Xiuying Liu, Lili Ren, Li Guo, Min Cheng, Hongli Zhou, Jianwei Wang, Qi Jin, Wei Yang   +10 more
doaj   +4 more sources

H7N9 Influenza Virus in China [PDF]

Cold Spring Harbor Perspectives in Medicine, 2020
In early 2013, human infections caused by a novel H7N9 avian influenza virus (AIV) were first reported in China; these infections caused severe disease and death. The virus was initially low pathogenic to poultry, enabling it to spread widely in different provinces, especially in live poultry markets.
Chengjun, Li, Hualan, Chen
openaire   +2 more sources