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H7N9 avian influenza virus - search and re-search

Emerging Microbes & Infections, 2013
In February 2013, two patients with severe pneumonia and pulmonary dysfunction were admitted to Shanghai Fifth Hospital affiliated with Fudan University. The first patient, an 87-year-old man became ill on February 19th and died on February 27th. The second patient, also male and 27 years old, became ill on February 27th and died on March 4th.
Wen, Yu-Mei, Klenk, Hans-Dieter
openaire   +2 more sources

Characterization and Immunogenicity of Influenza H7N9 Vaccine Antigens Produced Using a Serum-Free Suspension MDCK Cell-Based Platform

Viruses, 2022
Human infections with avian-origin H7N9 influenza A viruses were first reported in China, and an approximately 38% human mortality rate was described across six waves from February 2013 to September 2018.
Min-Yuan Chia, Chun-Yang Lin, Po-Ling Chen, Chia-Chun Lai, Tsai-Chuan Weng, Wang-Chou Sung, Alan Yung-Chih Hu, Min-Shi Lee   +7 more
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Adaptation of novel H7N9 influenza A virus to human receptors [PDF]

Scientific Reports, 2013
AbstractThe emergence of the novel H7N9 influenza A virus (IAV) has caused global concerns about the ability of this virus to spread between humans. Analysis of the receptor-binding properties of this virus using a recombinant protein approach in combination with fetuin-binding, glycan array and human tissue-binding assays demonstrates increased ...
Dortmans, JCFM, Dekkers, J, Wickramasinghe, INA, Verheije, MH, Rottier, PJM, van Kuppeveld, FJM, de Vries, E, de Haan, CAM   +7 more
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Structural Investigations and Binding Mechanisms of Oseltamivir Drug Resistance Conferred by the E119V Mutation in Influenza H7N9 Virus

Molecules, 2022
The use of vaccinations and antiviral medications have gained popularity in the therapeutic management of avian influenza H7N9 virus lately. Antiviral medicines are more popular due to being readily available. The presence of the neuraminidase protein in
Samuel C. Ugbaja, Sphamandla E. Mtambo, Aganze G. Mushebenge, Patrick Appiah-Kubi, Bahijjahtu H. Abubakar, Mthobisi L. Ntuli, Hezekiel M. Kumalo   +6 more
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A cross-sectional study of avian influenza in one district of Guangzhou, 2013. [PDF]

PLoS ONE, 2014
Since Feb, 2013, more than 100 human beings had been infected with novel H7N9 avian influenza virus. As of May 2013, several H7N9 viruses had been found in retail live bird markets (LBMs) in Guangdong province of southern China where several human cases ...
Haiming Zhang, Cong Peng, Xiaodong Duan, Dan Shen, Guanghua Lan, Wutao Xiao, Hai Tan, Ling Wang, Jialei Hou, Jiancui Zhu, Riwen He, Haibing Zhang, Lilan Zheng, Jianyu Yang, Zhen Zhang, Zhiwei Zhou, Wenhua Li, Mailing Hu, Jinhui Zhong, Yuhua Chen   +19 more
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Evaluation of MDCK cell-derived influenza H7N9 vaccine candidates in ferrets.

PLoS ONE, 2015
Avian-origin influenza A (H7N9) viruses emerged as human pathogens in China in early 2013 and have killed >100 persons. Influenza vaccines are mainly manufactured using egg-based technology which could not meet the surging demand during influenza ...
Min-Yuan Chia, Alan Yung-Chih Hu, Yu-Fen Tseng, Tsai-Chuan Weng, Chia-Chun Lai, Jun-Yang Lin, Po-Ling Chen, Ya-Fang Wang, Sin-Ru Chao, Jui-Yuan Chang, Yi-Shiuh Hwang, Chia-Tsui Yeh, Cheng-Ping Yu, Yee-Chun Chen, Ih-Jen Su, Min-Shi Lee   +15 more
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Toward Predicting Pandemic Potential: A Comparative Analysis of Virus‐Host Interactions Between Diverse Influenza A Viruses and the Human Innate Immune System

PROTEOMICS, EarlyView.
ABSTRACT Zoonotic infections caused by influenza A viruses (IAVs) of animal origin are a major public health concern, as they may represent the initial step toward the emergence of a pandemic strain. The host range of IAVs is shaped by species‐specific virus‐host interactions, and several host barriers have been identified that restrict the adaptation ...
Antoine Gerodez, Melanie Dos Santos, Mikaël Attia, Killian De Geest, Ibrahim Hamid, Rodrigue Tesse, Ilham Fdillate, Marc Boschmans, Steven Van Borm, Mieke Steensels, Benedicte Lambrecht, Lionel Tafforeau, Caroline Demeret, Cyril Barbezange   +13 more
wiley   +1 more source

Epidemiologic Characteristics of Cases for Influenza A(H7N9) Virus Infections in China [PDF]

Clinical Infectious Diseases, 2013
China's National Health and Family Planning Commission announced 3 deaths caused by avian-origin influenza A(H7N9) virus in March, which was the first time that the H7N9 strain has been found in humans.
Zhang, Wenyi, Wang, Liya, Hu, Wenbiao, Ding, Fan, Sun, Hailong, Li, Shenlong, Huang, Liuyu, Li, Chengyi   +7 more
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Two‐Dimensional Materials For Lateral Flow Assays: A Critical Review of Functional Roles and Translational Challenges

VIEW, EarlyView.
2D nanosheets, with large surface area, excellent optical/electrical properties, and high specificity, combine with lateral flow assay strips to enable rapid, readable detection, boosting the strips’ development and applications. Abstract Lateral flow assays (LFAs) are widely used for point‐of‐care diagnostics, but their detection capability remains ...
Weimin Xu, Ruping Liu, Na Gao, Jianxiao Zhu, Haowen Jiang, Shouzheng Jiao, Zhicheng Sun, Kai Shen, Gaolian Xu, Minghua Du, Ziyan Li, Yang Wang   +11 more
wiley   +1 more source

Development of a real-time RT-PCR method for the detection of newly emerged highly pathogenic H7N9 influenza viruses

Journal of Integrative Agriculture, 2017
In 2013, a human influenza outbreak caused by a novel H7N9 virus occurred in China. Recently, the H7N9 virus acquired multiple basic amino acids at its hemagglutinin (HA) cleavage site, leading to the emergence of a highly pathogenic virus.
Xiu-rong WANG, Lin-lin GU, Jian-zhong SHI, Hai-feng XU, Ying ZHANG, Xian-ying ZENG, Guo-hua DENG, Cheng-jun LI, Hua-lan CHEN   +8 more
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