Results 61 to 70 of about 9,717 (178)

Exosome‐Mediated Delivery of PROTACs for Targeted Protein Degradation in Cancer, Neurodegenerative, Infectious, and Inflammatory Diseases

Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are heterobifunctional molecules that hijack the ubiquitin‐proteasome system to drive catalytic, sub‐stoichiometric degradation of disease‐associated proteins, offering a mechanistic advantage over occupancy‐driven inhibitors and access to ‘undruggable’ targets.
Sruti Bagchi Ghosh, Rumpa Banerjee, Hailah M. Almohaimeed, Amany I. Almars, Tahani Ahmad ALMatrafi, Fayez M. Saleh, Zuhair M. Mohammedsaleh, Kranti Kiran Reddy Ealla, Ajoy Kumer, Bikram Dhara   +9 more
wiley   +1 more source

Palmitic Acid Promotes Antiviral Innate Immunity via ZDHHC20‐Mediated CMPK2 Palmitoylation

Advanced Science, Volume 13, Issue 37, 3 July 2026.
Metabolites have important functions in innate immune activation and regulation. Wang et al. uncover metabolic regulation of antiviral immunity through CMPK2 palmitoylation, which regulates CMPK2 mitochondrial localization and is promoted by ZDHHC20 but reversed by PPT1, inhibition of which antagonizes viral infection in mice.
Yujia Wang, Zenghui Cui, Yunkai Zhang, Zhiqing Li, Xuetao Cao   +4 more
wiley   +1 more source

Ecology of Low Pathogenicity Avian Influenza Virus H7 in Wild Birds in South‐Eastern Australia Prior to Emergence of High Pathogenicity Avian Influenza H7 in Poultry

Influenza and Other Respiratory Viruses, Volume 20, Issue 7, July 2026.
ABSTRACT Background Adding to the global burden of high pathogenicity avian influenza (HPAI) H5N1, five HPAI H7 outbreaks occurred globally in 2024. Of these, three occurred in South‐East Australia, with the independent emergence of HPAI H7N9, H7N8 and H7N3, resulting in the destruction of 2 million poultry.
Michelle Wille, Paul Eden, Silvia Ban de Gouvea Pedroso, Ian G. Barr, Allison Crawley, Kyeelee Driver, Victoria Jimenez, Peter D. Kirkland, Peter T. Mee, Matthew J. Neave, Kim O'Riley, Andrew J. Read, Vittoria Stevens, Teri Visentin, Andrew C. Breed, Marcel Klaassen   +15 more
wiley   +1 more source

Is avian influenza A (H7N9) virus staggering its way to humans?

Journal of the Formosan Medical Association, 2013
Human infections by a new avian influenza A (H7N9) virus have been reported. As of April 23, 2013, there were 108 confirmed cases including 22 deaths in China.
Guang-Wu Chen, Michael M.C. Lai, Suh-Chin Wu, Shih-Cheng Chang, Li-Min Huang, Shin-Ru Shih   +5 more
doaj   +1 more source

Three‐Dimensional Magnetic Multi‐Metallic Nanozymes With Colorimetric and Catalytic Amplification for Rapid and Highly‐Sensitive Detection of Influenza A

Exploration, Volume 6, Issue 3, June 2026.
The application of nanozymes in LFIA greatly improved the situation of insufficient colorimetric signals by catalytic reaction. 3D magnetic multi‐metallic nanozymes integrated the characteristics of great magnetism, enhanced colorimetric signal, and outstanding POD‐like activity, and were applied to LFIA for rapid and accurate detection of Influenza A ...
Zhenzhen Liu, Pengyou Zhou, Xiaofei Jia, Xiaoxian Liu, Yong Yang, Yansong Sun, Rui Xiao   +6 more
wiley   +1 more source

PCR for Detection of Oseltamivir Resistance Mutation in Influenza A(H7N9) Virus

Emerging Infectious Diseases, 2014
Sensitive molecular techniques are needed for rapid detection of the R292K oseltamivir-resistant mutant of influenza A(H7/N9) virus strain to monitor its transmission and guide antiviral treatment.
Wei Wang, Zhigang Song, Wencai Guan, Yi Liu, Xiaonan Zhang, Lei Xu, Jianhua Li, Zhenghong Yuan, Yunwen Hu   +8 more
doaj   +1 more source

Transmission of H7N9 influenza virus in mice by different infective routes [PDF]

Virology Journal, 2014
On 19 February 2013, the first patient infected with a novel influenza A H7N9 virus from an avian source showed symptoms of sickness. More than 349 laboratory-confirmed cases and 109 deaths have been reported in mainland China since then. Laboratory-confirmed, human-to-human H7N9 virus transmission has not been documented between individuals having ...
Bao, Linlin, Xu, Lili, Zhu, Hua, Deng, Wei, Chen, Ting, Lv, Qi, Li, Fengdi, Yuan, Jing, Xu, Yanfeng, Li, Yanhong, Liu, Jiangning, Yao, Yanfeng, Yu, Pin, Chen, Honglin, Qin, Chuan, Huang, Lan   +15 more
openaire   +5 more sources

Development and Validation of a Nomogram to Predict Respiratory Failure With Influenza

Immunity, Inflammation and Disease, Volume 14, Issue 6, June 2026.
ABSTRACT Purpose Influenza‐induced respiratory failure is a severe complication of influenza that can rapidly progress to multi‐organ failure or even death due to severe impairment of pulmonary ventilation or gas exchange function. Early prediction and intervention can decrease the mortality in patients with respiratory failure. Methods A comprehensive
Mingzhen Zhao, Yi Li, Hongxiang Fu, Guanghui Jia, Xing Zhao, Yu Sun, Xingbin Li, Hongbo Zhang, Zhiwei Zhao   +8 more
wiley   +1 more source

Applying Baculovirus Surface Display Technology for Influenza Cytokine Profiling, Serological Detection and Antiviral Screening

Microbial Biotechnology, Volume 19, Issue 6, June 2026.
By displaying the hemagglutinin (HA) or neuraminidase (NA) proteins of influenza viruses on the surface of baculoviruses and infected insect cells, a safe and flexible pseudovirus system capable of performing cytokine analysis, serological detection and antiviral drug screening is established.
Li‐Yun Cheng, Zheng Yu Phan, Chi‐Wei Wang, Ching‐Fen Shen, Ping‐Chung Kuo, Hao‐Ze Li, Yu‐Chan Chao, Chih‐Hsuan Tsai   +7 more
wiley   +1 more source

Environmental Sampling for Avian Influenza A(H7N9) in Live-Poultry Markets in Guangdong, China. [PDF]

PLoS ONE, 2015
To provide an increased understanding of avian influenza A(H7N9) activity in live-poultry market in space and time and hence improve H7N9 epidemic control, an ongoing environmental sampling program in multiple live-poultry markets across Guangdong, China
Min Kang, Jianfeng He, Tie Song, Shannon Rutherford, Jie Wu, Jinyan Lin, Guofeng Huang, Xiaohua Tan, Haojie Zhong   +8 more
doaj   +1 more source