Results 1 to 10 of about 10,448 (161)

A System Based-Approach to Examine Host Response during Infection with Influenza A Virus Subtype H7N9 in Human and Avian Cells [PDF]

Cells, 2020
Although the influenza A virus H7N9 subtype circulates within several avian species, it can also infect humans with a severe disease outcome. To better understand the biology of the H7N9 virus we examined the host response to infection in avian and human
Biruhalem Taye, Hui Chen, Richard J Sugrue   +2 more
exaly   +7 more sources

Virus subtype-specific suppression of MAVS aggregation and activation by PB1-F2 protein of influenza A (H7N9) virus

PLoS Pathogens, 2020
Human infection with avian influenza A (H5N1) and (H7N9) viruses causes severe respiratory diseases. PB1-F2 protein is a critical virulence factor that suppresses early type I interferon response, but the mechanism of its action in relation to high ...
Pak-Hin Hinson Cheung, Tak-Wang Terence Lee, Honglin Chen   +2 more
exaly   +6 more sources

Development of an Inactivated H7N9 Subtype Avian Influenza Serological DIVA Vaccine Using the Chimeric HA Epitope Approach

Microbiology Spectrum, 2021
H7N9 avian influenza virus (AIV) is an emerging zoonotic pathogen, and it is necessary to develop a differentiating infected from vaccinated animals (DIVA) vaccine for the purpose of eradication. H7N9 subtype AIV hemagglutinin subunit 2 glycoprotein (HA2)
Sujuan Chen, Tao Qin, Hongwei Ma
exaly   +4 more sources

Visual detection of human infection with influenza A (H7N9) virus by subtype-specific reverse transcription loop-mediated isothermal amplification with hydroxynaphthol blue dye [PDF]

Clinical Microbiology and Infection, 2013
A rapid and sensitive H7 and N9 subtype-specific reverse transcription loop-mediated isothermal amplification assay was developed respectively for visual detection of human-infected influenza A (H7N9) virus. The reaction was performed in one step in a single tube at 63°C for 60 min with the addition of hydroxynaphthol blue dye before amplification. The
Xiong Ding
exaly   +4 more sources

An Investigational Antiviral Drug, DAS181, Effectively Inhibits Replication of Zoonotic Influenza A Virus Subtype H7N9 and Protects Mice From Lethality [PDF]

Journal of Infectious Diseases, 2014
Human infections caused by avian influenza A virus type subtype H7N9 have been associated with substantial morbidity and mortality. Emergence of virus variants carrying markers of decreased susceptibility to neuraminidase inhibitors was reported.
Henju Marjuki, Vasiliy P Mishin, Julie Villanueva   +2 more
exaly   +4 more sources

Development of Rapid Immunochromatographic Test for Hemagglutinin Antigen of H7 Subtype in Patients Infected with Novel Avian Influenza A (H7N9) Virus

PLoS ONE, 2014
Since human infection with the novel H7N9 avian influenza virus was identified in China in March 2013, the relatively high mortality rate and possibility of human-to-human transmission have highlighted the urgent need for sensitive and specific assays for diagnosis of H7N9 infection.We developed a rapid diagnostic test for the novel avian influenza A ...
Cheng-Feng Qin, Emmanuel Enoch Dzakah, Xiao-Chun Luo   +2 more
exaly   +6 more sources

Accelerated Evolution of H7N9 Subtype Influenza Virus under Vaccination Pressure [PDF]

Virologica Sinica, 2021
No avian H7N9 outbreaks have occurred since the introduction of H7N9 inactivated vaccine in the fall of 2017. However, H7N9 is still prevalent in poultry. To surveil the prevalence, genetic characteristics, and antigenic changes of H7N9, over 7000 oropharyngeal and cloaca swab specimens were collected from live poultry markets and farms in 15 provinces
Yifan Wu, Jingkai Hu, Xuanjiang Jin, Xiao Li, Jinfeng Wang, Mengmeng Zhang, Jianglin Chen, Shumin Xie, Wenbao Qi, Ming Liao, Weixin Jia   +10 more
openaire   +3 more sources

The Character of Influenza Virus the H7 Subtype and Alert to Novel Influenza Virus H7N9 Subtype Virus

Indonesian Bulletin of Animal and Veterinary Sciences, 2014
Influenza virus subtype H7 influenza viruses as well as other influenza virus geographically divided into two distinct genetic lineages, North American (H7N2, H7N3) or Eurasian (H7N7 and H7N3). Unlike the AI virus subtypes H5, since 1997 until now, all the infections caused by the H5 virus has Neuraminidase subtype 1 but H7 subtype of AI virus that ...
NLP Indi Dharmayanti, Bahri S
openaire   +2 more sources

OBTAINING MRNA ENCODING HEMAGGLUTININ OF INFLUENZA A VIRUS SUBTYPE H7N9 BY IN VITRO TRANSCRIPTION AND EVALUATION OF THE EFFICIENCY OF TRANSLATION OF THE OBTAINED MRNA IN THE EUKARYOTIC CELL LINE A549

X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023: Cб. тез., 2023
RNA-based vaccines are the newest promising alternative to traditional approaches to treat viral diseases. In this study, we obtained mRNA encoding the hemagglutinin of influenza A subtype H7N9 by in vitro transcription and evaluated the efficiency of its translation on the A549 cell line.
O.A. Dobrovolskaya, E.A. Elpaeva, V.V. Vysochinskaya   +2 more
openaire   +2 more sources

Direct airway delivery of a humanized anti-H7N9 neutralizing antibody broadly protects against divergent H7 influenza viruses in the mouse model [PDF]

Journal of Virology
Passive administration of broadly neutralizing anti-influenza monoclonal antibodies (mAbs) before or after virus infection can prevent or alleviate disease.
Wang Yu, Xiaozheng He, Jiangyan Zhao, Yunlong Dou, Tingyu Hu, Xia Chen, Xuran Ma, Xiaoquan Wang, Shunlin Hu, Jiao Hu, Xiufan Liu, Zenglei Hu   +11 more
doaj   +2 more sources