Results 31 to 40 of about 10,711 (202)

The PA-X host shutoff site 100 V exerts a contrary effect on viral fitness of the highly pathogenic H7N9 influenza A virus in mice and chickens

Virulence
Several viruses, including influenza A virus (IAV), encode viral factors to hijack cellular RNA biogenesis processes to direct the degradation of host mRNAs, termed “host shutoff.” Host shutoff enables viruses to simultaneously reduce antiviral responses
Xia Chen, Ming Kong, Chunxi Ma, Manyu Zhang, Zenglei Hu, Min Gu, Xiaoquan Wang, Ruyi Gao, Shunlin Hu, Yu Chen, Xiaowen Liu, Daxin Peng, Xiufan Liu, Jiao Hu   +13 more
doaj   +2 more sources

Potential geographic distribution of the novel avian-origin influenza A (H7N9) virus. [PDF]

PLoS ONE, 2014
BackgroundIn late March 2013, a new avian-origin influenza virus emerged in eastern China. This H7N9 subtype virus has since infected 240 people and killed 60, and has awakened global concern as a potential pandemic threat.
Gengping Zhu, A Townsend Peterson
doaj   +2 more sources

A cross-sectional study of avian influenza in one district of Guangzhou, 2013. [PDF]

PLoS ONE, 2014
Since Feb, 2013, more than 100 human beings had been infected with novel H7N9 avian influenza virus. As of May 2013, several H7N9 viruses had been found in retail live bird markets (LBMs) in Guangdong province of southern China where several human cases ...
Haiming Zhang, Cong Peng, Xiaodong Duan, Dan Shen, Guanghua Lan, Wutao Xiao, Hai Tan, Ling Wang, Jialei Hou, Jiancui Zhu, Riwen He, Haibing Zhang, Lilan Zheng, Jianyu Yang, Zhen Zhang, Zhiwei Zhou, Wenhua Li, Mailing Hu, Jinhui Zhong, Yuhua Chen   +19 more
doaj   +1 more source

Route of Inoculation Determines Symptom Profile and Replication Dynamics After low Pathogenic Avian Influenza A(H7N9) Virus Infection in Ferrets. [PDF]

Influenza Other Respir Viruses
ABSTRACT Background Although influenza A viruses (IAVs) are respiratory pathogens, infections may occur via nonrespiratory routes. However, the effects of different routes of exposure on the course of infection and disease are not well characterized.
Wong SS, Zanin M, Song MS, Contreras C, Fabrizio TP, Hong EK, Kim HK, Na W, Webby RJ, Yoon SW.   +9 more
europepmc   +2 more sources

Cross-reactivity between avian influenza A (H7N9) virus and divergent H7 subtypic- and heterosubtypic influenza A viruses [PDF]

Scientific Reports, 2016
AbstractThe number of human avian H7N9 influenza infections has been increasing in China. Understanding their antigenic and serologic relationships is crucial for developing diagnostic tools and vaccines. Here, we evaluated the cross-reactivities and neutralizing activities among H7 subtype influenza viruses and between H7N9 and heterosubtype influenza
Li Guo, Dayan Wang, Hongli Zhou, Chao Wu, Xin Gao, Yan Xiao, Lili Ren, Gláucia Paranhos-Baccalà, Yuelong Shu, Qi Jin, Jianwei Wang   +10 more
openaire   +2 more sources

An analysis of microbiota-targeted therapies in patients with avian influenza virus subtype H7N9 infection [PDF]

BMC Infectious Diseases, 2014
Abstract Background Selective prophylactic decontamination of the digestive tract is a strategy for the prevention of secondary nosocomial infection in patients with avian influenza virus subtype H7N9 infection. Our aim was to summarize the effectiveness of these therapies in re-establishing a stable and diverse ...
Lu, Haifeng, Zhang, Chunxia, Qian, Guirong, Hu, Xinjun, Zhang, Hua, Chen, Chunlei, Liang, Weifeng, Gao, Hainv, Yang, Yunmei, Li, Lanjuan   +9 more
openaire   +2 more sources

Nucleic acid-based detection of influenza A virus subtypes H7 and N9 with a special emphasis on the avian H7N9 virus [PDF]

Eurosurveillance, 2014
In 2013, a novel influenza A virus of subtype H7N9 was transmitted from avian sources to humans in China, causing severe illness and substantial mortality. Rapid and sensitive diagnostic approaches are the basis of epidemiological studies and of utmost importance for the detection of infected humans and animals.
Pohlmann, A., Harder, T., Grund, C., Kalthoff, D., Hoffmann, B., Beer, M., Bogs, J.   +6 more
openaire   +2 more sources

AS03-adjuvanted H7N9 inactivated split virion vaccines induce cross-reactive and protective responses in ferrets

npj Vaccines, 2021
Human infections with avian H7N9 subtype influenza viruses are a major public health concern and vaccines against H7N9 are urgently needed for pandemic preparedness.
Daniel Stadlbauer, Leon de Waal, Edith Beaulieu, Shirin Strohmeier, Edwin J. B. Veldhuis Kroeze, Philippe Boutet, Albert D. M. E. Osterhaus, Florian Krammer, Bruce L. Innis, Raffael Nachbagauer, Koert J. Stittelaar, Corey P. Mallett   +11 more
doaj   +1 more source

Development of a Reverse Transcription Loop-Mediated Isothermal Amplification Method for the Rapid Detection of Subtype H7N9 Avian Influenza Virus [PDF]

BioMed Research International, 2014
A novel influenza A (H7N9) virus has emerged in China. To rapidly detect this virus from clinical samples, we developed a reverse transcription loop-mediated isothermal amplification (RT-LAMP) method for the detection of the H7N9 virus. The minimum detection limit of the RT-LAMP assay was 0.01 PFU H7N9 virus, making this method 100-fold more sensitive ...
Bao, Hongmei, Zhao, Yuhui, Wang, Yunhe, Xu, Xiaolong, Shi, Jianzhong, Zeng, Xianying, Wang, Xiurong, Chen, Hualan   +7 more
openaire   +2 more sources

Avian-to-Human Receptor-Binding Adaptation of Avian H7N9 Influenza Virus Hemagglutinin

Cell Reports, 2019
Summary: Since 2013, H7N9 avian influenza viruses (AIVs) have caused more than 1,600 human infections, posing a threat to public health. An emerging concern is whether H7N9 AIVs will cause pandemics among humans. Molecular analysis of hemagglutinin (HA),
Ying Xu, Ruchao Peng, Wei Zhang, Jianxun Qi, Hao Song, Sheng Liu, Haiyuan Wang, Min Wang, Haixia Xiao, Lifeng Fu, Zheng Fan, Yuhai Bi, Jinghua Yan, Yi Shi, George F. Gao   +14 more
doaj   +1 more source