Results 51 to 60 of about 114,195,449 (202)

Generation of replication-proficient Influenza Virus NS1 point mutants with interferon-hyperinducer phenotype [PDF]

, 2014
The NS1 protein of influenza A viruses is the dedicated viral interferon (IFN)-antagonist. Viruses lacking NS1 protein expression cannot multiply in normal cells but are viable in cells deficient in their ability to produce or respond to IFN.
Fernández, Yolanda, Juan Ortín, Randall, Richard E, Richard E. Randall (190211), Killip, Marian J, Víctor J Asensio, Bengoechea, José A, Pérez-Cidoncha, M, Marian J. Killip (571160), Marian J Killip, Maite Pérez-Cidoncha (195699), Ortín, Juan, Killip, MJ, Ortín, J, Richard E Randall, Juan Ortín (5649007), Yolanda Fernández, Fernández, Y, Asensio, Víctor J, Randall, RE, José A Bengoechea, José A. Bengoechea (124595), Pérez-Cidoncha, Maite, Bengoechea, JA, Víctor J. Asensio (571161), Bengoechea, José A; id_orcid, Maite Pérez-Cidoncha, Asensio, VJ, Yolanda Fernández (268684), Bengoechea, Jose Antonio, Asensio, Víctor José, Randall, Richard E.   +31 more
core   +2 more sources

Enhancing Immune Response and Heterosubtypic Protection Ability of Inactivated H7N9 Vaccine by Using STING Agonist as a Mucosal Adjuvant

Frontiers in Immunology, 2019
Influenza vaccines for H7N9 subtype have shown low immunogenicity in human clinical trials. Using novel adjuvants might represent the optimal available option in vaccine development.
Jian Luo, Jian Luo, Xu-ping Liu, Fei-fei Xiong, Fei-xia Gao, Ying-lei Yi, Min Zhang, Ze Chen, Wen-song Tan   +8 more
doaj   +1 more source

Cloned defective interfering influenza virus protects ferrets from pandemic 2009 influenza A virus and allows protective immunity to be established [PDF]

, 2012
Influenza A viruses are a major cause of morbidity and mortality in the human population, causing epidemics in the winter, and occasional worldwide pandemics.
Cheung, Linda, Dimmock Nigel J., Dove, Brian K., Scott, P. D. (Paul D.), Carroll, Miles W., Linda Cheung, Miles W Carroll, Brian K Dove, Dove Brian K., Taylor Irene, Bassam Hallis, Meng, Bo, Easton, A. J. (Andrew J.), Marriott, Anthony C., Hallis, Bassam, Miles W. Carroll (111071), Dimmock, N. J., Linda Cheung (71020), Andrew J. Easton (111072), Irene Taylor (111066), Scott Paul D., Bo Meng (111065), Hallis Bassam, Taylor, Irene, Andrew J Easton, Paul D Scott, Bo Meng, Brian K. Dove (111063), Meng Bo, Paul D. Scott (111064), Nigel J Dimmock, Marriott Anthony C., Irene Taylor, Anthony C Marriott, Nigel J. Dimmock (111061), Carroll Miles W., Cheung Linda, Bassam Hallis (111069), Easton Andrew J., Anthony C. Marriott (111070)   +39 more
core   +2 more sources

Engineering Antibodies into Targeted Chimeras: From Recognition Modules to Programmable Degraders

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Antibody can be engineered into diverse lysosome‐targeting chimeras that convert target recognition into active degradation. By coupling antibody binding with recruited receptors, encoded domains, conjugated ligands, or nanoparticle scaffolds, these antibody‐associated targeted chimeras (AbTACs) platforms direct extracellular and membrane proteins ...
Kaige Chen, Quanyin Hu
wiley   +1 more source

Further evidence of the circulation of PMV-4 and influenza viruses with N2 - 1957 enzyme in migratory waterfowls [PDF]

, 1989
I n the years 1980—1984, one paramyxovirus type 4 and 11 influenza viruses were isolated from cloacal swabs collected from migratory waterfowls in Fed. Rep. Germany.
Pfleger, A., Eichhorn, Werner, Tumova, B., Stumpa, A., Bachmann, P. A.   +4 more
core   +1 more source

Overview of the Epizootiological Situation on Highly Pathogenic Avian Influenza Virus in Russia in 2019

Проблемы особо опасных инфекций, 2020
This review describes the current situation on highly pathogenic avian influenza virus in 2019 and predicts the possible further spread of avian influenza in Russia.
V. Yu. Marchenko, N. I. Goncharova, Thi Nhai Tran, Khac Sau Trinh, Ngoc Quyen Nguyen, E. V. Gavrilova, R. A. Maksyutov, A. B. Ryzhikov   +7 more
doaj   +1 more source

PB2-Q591K Mutation Determines the Pathogenicity of Avian H9N2 Influenza Viruses for Mammalian Species. [PDF]

PLoS ONE, 2016
Influenza A subtype H9N2 is widespread and prevalent in poultry. It has repeatedly transmitted zoonotically to cause mild influenza-like illness in humans and is regarded as a potential pandemic candidate.
Congrong Wang, Horace Hok Yeung Lee, Zi Feng Yang, Chris Ka Pun Mok, Zhi Zhang   +4 more
doaj   +1 more source

CD4+ T‐cell responses directed towards A/H5N1‐derived haemagglutinin peptides increase in patients with seasonal influenza A virus infection

Clinical &Translational Immunology, Volume 15, Issue 8, 2026.
Abstract Objectives Recent outbreak of influenza A/H5N1 viral infections in birds and mammals worldwide prompted renewed concerns over an emerging H5N1‐related influenza pandemic in the generally immunologically‐naive global population. Cross‐reactive CD4+ T cells between A/H1N1 and A/H5N1 subtypes targeting internal and surface influenza proteins have
Lilith F Allen, Louise C Rowntree, Mitchell Jenzen, Ruth R Hagen, Nathan P Croft, Fiona James, Genevieve E Martin, Anthony W Purcell, Patricia T Illing, Steven Y C Tong, Allen C Cheng, Tom C Kotsimbos, Jason A Trubiano, Katherine Kedzierska, Thi H O Nguyen   +14 more
wiley   +1 more source

Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase [PDF]

, 2010
This work was supported by the Medical Research Council and the Scottish Funding Council.Influenza virus sialidase has an essential role in the virus’ life cycle.
Russell, Rupert James Martin, Thomson, Robin J, Thomson, Robin, Dyason, Jeffrey C, von Itzstein, M, Naffakh, Nadia, S. Kerry, Philip, Nadia Naffakh, Mark von Itzstein, Faith J. Rose, Rameix-Welti, Marie-Anne, Robin J. Thomson, Dyason, Jeffrey, Dyason, JC, Rupert J. M. Russell, van der Werf, S, Russell, Rupert J M, Santosh Rudrawar, Rose, Faith J, Russell, Rupert JM, Kerry, Philip Stephen, Jeffrey C. Dyason, von Itzstein, Mark, Thomson, RJ, J.M. Russell, Rupert, Rudrawar, S, Marie-Anne Rameix-Welti, Kerry, Philip S, Rose, FJ, Naffakh, N, Rameix-Welti, MA, Philip S. Kerry, van Der Werf, Sylvie, Rose, Faith, Rudrawar, Santosh, Sylvie van der Werf   +35 more
core   +1 more source

Pathobiology of avian influenza in wild bird species [PDF]

, 2012
Avian influenza viruses, especially highly pathogenic avian influenza viruses (HPAIV), affect a wide range of species, including humans and have thus become a major concern for veterinary medicine and public health.
Bröjer, Caroline
core   +1 more source