Results 1 to 10 of about 10,426 (187)

Genetic and biological properties of H7N9 avian influenza viruses detected after application of the H7N9 poultry vaccine in China

PLoS Pathogens, 2021
The H7N9 avian influenza virus (AIV) that emerged in China have caused five waves of human infection. Further human cases have been successfully prevented since September 2017 through the use of an H7N9 vaccine in poultry.
Xin Yin, Guohua Deng, Xianying Zeng
exaly   +2 more sources

Influenza virus infection drives upregulation of CD84 across a broad range of immune cells. [PDF]

Clin Transl Immunology
Our findings reveal a link between high CD84 expression in humans and recovery from respiratory viral infections. In influenza virus‐infected mice, CD84 is upregulated on a broad range of innate and adaptive immune cell populations, particularly on activated and influenza virus‐specific T‐cell populations and associated with less disease severity ...
Jia X, Foo IJ, McQuilten HA, Crawford JC, Cabug AF, Gebregzabher D, Chou J, Mettelman RC, Novak T, Van de Velde LA, Thwaites RS, Randolph AG, Thomas PG, Xu J, Wang Z, Kedzierska K, Kedzierski L, Chua BY.   +17 more
europepmc   +2 more sources

H7N9 Influenza Virus in China [PDF]

Cold Spring Harbor Perspectives in Medicine, 2020
In early 2013, human infections caused by a novel H7N9 avian influenza virus (AIV) were first reported in China; these infections caused severe disease and death. The virus was initially low pathogenic to poultry, enabling it to spread widely in different provinces, especially in live poultry markets.
Chengjun, Li, Hualan, Chen
openaire   +2 more sources

Extra Oversight for H7N9 Experiments [PDF]

Science, 2013
The U.S. Department of Health and Human Services (HHS) announces a new review process for certain gain-of-function (GOF) experiments with the avian influenza A (H7N9) virus, some of which are proposed this week by influenza scientists. Specifically, before being undertaken using funds from the HHS, proposed studies that are reasonably anticipated to ...
Harold, Jaffe, Amy P, Patterson, Nicole, Lurie   +2 more
openaire   +2 more sources

H7N9 Influenza Virus Containing a Polybasic HA Cleavage Site Requires Minimal Host Adaptation to Obtain a Highly Pathogenic Disease Phenotype in Mice

Viruses, 2020
Low pathogenic avian influenza (LPAI) H7N9 viruses have recently evolved to gain a polybasic cleavage site in the hemagglutinin (HA) protein, resulting in variants with increased lethality in poultry that meet the criteria for highly pathogenic avian ...
Mable Chan, Anders Leung, Tamiko Hisanaga, Brad Pickering, Bryan D. Griffin, Robert Vendramelli, Nikesh Tailor, Gary Wong, Yuhai Bi, Shawn Babiuk, Yohannes Berhane, Darwyn Kobasa   +11 more
doaj   +1 more source

Gain-of-Function Experiments on H7N9 [PDF]

Science, 2013
Since the end of March 2013, avian influenza A viruses of the H7N9 subtype have caused more than 130 human cases of infection in China, many of which were severe, resulting in 43 fatalities. Although this A(H7N9) outbreak is now under control, the virus (or one with similar properties) could re-emerge as winter approaches.To better assess the pandemic ...
Guan, Y, Peiris, JSM, Steel, J, Tompkins, SM, Topham, DJ, Treanor, JJ, Tripp, RA, Webby, RJ, Webster, RG, Smith, DJ, Compans, RW, García-Sastre, A, Govorkova, EA, Herfst, S, Orenstein, WA, Perez, DR, Richt, JA, Russell, C, Schultz-Cherry, SL, Cardona, C, Fouchier, RA, Kawaoka, Y   +21 more
openaire   +7 more sources

Surveillance of Avian H7N9 Virus in Various Environments of Zhejiang Province, China before and after Live Poultry Markets Were Closed in 2013-2014. [PDF]

PLoS ONE, 2015
To date, there have been a total of 637 laboratory-confirmed cases of human infection with avian influenza A (H7N9) virus across mainland China, with 28% (179/637) of these reported in Zhejiang Province.
Xiaoxiao Wang, Shelan Liu, Haiyan Mao, Zhao Yu, Enfu Chen, Chengliang Chai   +5 more
doaj   +1 more source

Human to human transmission of H7N9 [PDF]

BMJ, 2013
Since the new avian influenza virus, H7N9, first emerged in China, a primary concern has been whether it might spread between humans. The vast majority of the 133 confirmed cases reported so far seem to be epidemiologically unconnected, with many patients reporting a recent history of exposure to live poultry, which are suspected to be a main reservoir
Rudge, James W, Coker, Richard
openaire   +2 more sources

Development of rapid immunochromatographic test for hemagglutinin antigen of H7 subtype in patients infected with novel avian influenza A (H7N9) virus. [PDF]

PLoS ONE, 2014
BACKGROUND: Since human infection with the novel H7N9 avian influenza virus was identified in China in March 2013, the relatively high mortality rate and possibility of human-to-human transmission have highlighted the urgent need for sensitive and ...
Keren Kang, Li Chen, Xiang Zhao, Chengfeng Qin, Zanwu Zhan, Jihua Wang, Wenmei Li, Emmanuel E Dzakah, Weijuang Huang, Yuelong Shu, Tao Jiang, Wuchun Cao, Mingquan Xie, Xiaochun Luo, Shixing Tang   +14 more
doaj   +1 more source

Hemagglutinin-Specific Non-neutralizing Antibody Is Essential for Protection Provided by Inactivated and Viral-Vectored H7N9 Avian Influenza Vaccines in Chickens

Frontiers in Veterinary Science, 2020
Hemagglutination inhibition (HI) and virus neutralization antibody (nAb) do not always correlate with the protection of H7 avian influenza vaccines in mammals and humans.
Zenglei Hu, Zenglei Hu, Zenglei Hu, Zenglei Hu, Jiangyan Zhao, Yiheng Zhao, Xuelian Fan, Jiao Hu, Jiao Hu, Lei Shi, Xiaoquan Wang, Xiaoquan Wang, Xiaowen Liu, Xiaowen Liu, Shunlin Hu, Shunlin Hu, Min Gu, Min Gu, Yongzhong Cao, Yongzhong Cao, Yongzhong Cao, Xiufan Liu, Xiufan Liu, Xiufan Liu, Xiufan Liu   +24 more
doaj   +1 more source