Results 1 to 10 of about 13,281 (220)

Genetic and biological properties of H7N9 avian influenza viruses detected after application of the H7N9 poultry vaccine in China

PLoS Pathogens, 2021
The H7N9 avian influenza virus (AIV) that emerged in China have caused five waves of human infection. Further human cases have been successfully prevented since September 2017 through the use of an H7N9 vaccine in poultry.
Yulei Li, Chengjun Li, Hualan Chen
exaly   +3 more sources

The Protective Effects of the A/ZJU01/ PR8/2013 Split H7N9 Avian Influenza Vaccine Against Highly Pathogenic H7N9 in BALB/c Mice

Cellular Physiology and Biochemistry, 2018
Background/Aims: Since the first case of novel H7N9 infection was reported, China has experienced five epidemics of H7N9. During the fifth wave, a highly pathogenic H7N9 strain emerged. In order to assess whether the H7N9 vaccine based on A/Zhejiang/DTID-
Xiao-Xin Wu, Xi-Long Deng, Dong-Shan Yu, Wei Yao, Hui-Lin Ou, Tian-Hao Weng, Chen-Yu Hu, Feng-Yu Hu, Nan-Ping Wu, Hangping Yao, Fu-Chun Zhang, Lan-Juan Li   +11 more
doaj   +3 more sources

Gain-of-Function Experiments on H7N9 [PDF]

Science, 2013
Since the end of March 2013, avian influenza A viruses of the H7N9 subtype have caused more than 130 human cases of infection in China, many of which were severe, resulting in 43 fatalities. Although this A(H7N9) outbreak is now under control, the virus (or one with similar properties) could re-emerge as winter approaches.To better assess the pandemic ...
Guan, Y, Peiris, JSM, Steel, J, Tompkins, SM, Topham, DJ, Treanor, JJ, Tripp, RA, Webby, RJ, Webster, RG, Smith, DJ, Compans, RW, García-Sastre, A, Govorkova, EA, Herfst, S, Orenstein, WA, Perez, DR, Richt, JA, Russell, C, Schultz-Cherry, SL, Cardona, C, Fouchier, RA, Kawaoka, Y   +21 more
openaire   +9 more sources

H7N9 Influenza Virus in China [PDF]

Cold Spring Harbor Perspectives in Medicine, 2020
In early 2013, human infections caused by a novel H7N9 avian influenza virus (AIV) were first reported in China; these infections caused severe disease and death. The virus was initially low pathogenic to poultry, enabling it to spread widely in different provinces, especially in live poultry markets.
Chengjun, Li, Hualan, Chen
openaire   +2 more sources

Extra Oversight for H7N9 Experiments [PDF]

Science, 2013
The U.S. Department of Health and Human Services (HHS) announces a new review process for certain gain-of-function (GOF) experiments with the avian influenza A (H7N9) virus, some of which are proposed this week by influenza scientists. Specifically, before being undertaken using funds from the HHS, proposed studies that are reasonably anticipated to ...
Harold, Jaffe, Amy P, Patterson, Nicole, Lurie   +2 more
openaire   +2 more sources

H7N9 Influenza Virus Containing a Polybasic HA Cleavage Site Requires Minimal Host Adaptation to Obtain a Highly Pathogenic Disease Phenotype in Mice

Viruses, 2020
Low pathogenic avian influenza (LPAI) H7N9 viruses have recently evolved to gain a polybasic cleavage site in the hemagglutinin (HA) protein, resulting in variants with increased lethality in poultry that meet the criteria for highly pathogenic avian ...
Mable Chan, Anders Leung, Tamiko Hisanaga, Brad Pickering, Bryan D. Griffin, Robert Vendramelli, Nikesh Tailor, Gary Wong, Yuhai Bi, Shawn Babiuk, Yohannes Berhane, Darwyn Kobasa   +11 more
doaj   +1 more source

Surveillance of Avian H7N9 Virus in Various Environments of Zhejiang Province, China before and after Live Poultry Markets Were Closed in 2013-2014. [PDF]

PLoS ONE, 2015
To date, there have been a total of 637 laboratory-confirmed cases of human infection with avian influenza A (H7N9) virus across mainland China, with 28% (179/637) of these reported in Zhejiang Province.
Xiaoxiao Wang, Shelan Liu, Haiyan Mao, Zhao Yu, Enfu Chen, Chengliang Chai   +5 more
doaj   +1 more source

Human to human transmission of H7N9 [PDF]

BMJ, 2013
Since the new avian influenza virus, H7N9, first emerged in China, a primary concern has been whether it might spread between humans. The vast majority of the 133 confirmed cases reported so far seem to be epidemiologically unconnected, with many patients reporting a recent history of exposure to live poultry, which are suspected to be a main reservoir
Rudge, James W, Coker, Richard
openaire   +2 more sources

Identifying novel amino acid substitutions of hemagglutinin involved in virulence enhancement in H7N9 virus strains

Virology Journal, 2021
Background To identify site-specific features of amino acid substitutions that confer enhanced H7N9 virulence in humans, we independently generated mammalian-adapted variants of A/Anhui/1/2013 (AH-H7N9) and A/Shanghai/2/2013 (SH-H7N9) by serial passaging
Ting Zhang, Haiwei Du, Li Guo, Feng Liu, Haoxiang Su, Fan Yang   +5 more
doaj   +1 more source

Supplementation of H7N9 Virus-Like Particle Vaccine With Recombinant Epitope Antigen Confers Full Protection Against Antigenically Divergent H7N9 Virus in Chickens

Frontiers in Immunology, 2022
The continuous evolution of the H7N9 avian influenza virus suggests a potential outbreak of an H7N9 pandemic. Therefore, to prevent a potential epidemic of the H7N9 influenza virus, it is necessary to develop an effective crossprotective influenza ...
Dexin Kong, Dexin Kong, Dexin Kong, Dexin Kong, Taoran Chen, Taoran Chen, Taoran Chen, Taoran Chen, Xiaolong Hu, Xiaolong Hu, Xiaolong Hu, Xiaolong Hu, Shaorong Lin, Shaorong Lin, Shaorong Lin, Shaorong Lin, Yinze Gao, Yinze Gao, Yinze Gao, Yinze Gao, Chunmei Ju, Ming Liao, Ming Liao, Ming Liao, Ming Liao, Huiying Fan, Huiying Fan, Huiying Fan, Huiying Fan   +28 more
doaj   +1 more source