Results 41 to 50 of about 13,281 (220)

Saliva as a source of reagent to study human susceptibility to avian influenza H7N9 virus infection

Emerging Microbes and Infections, 2018
Avian influenza H7N9 viruses are an important public health concern due to their high mortality rate and potentials for future pandemics. We investigated human susceptibility to H7N9 viruses using recombinant H7N9 hemagglutinin (HA) proteins as a probe ...
Ming Tan, Lunbiao Cui, Xiang Huo, Ming Xia, Fengjuan Shi, Xiaoyan Zeng, Pengwei Huang, Weiming Zhong, Weiwei Li, Ke Xu, Liling Chen, Minghao Zhou, Xi Jiang   +12 more
doaj   +1 more source

Allosteric Neutralization by Human H7N9 Antibodies

, 2023
Abstract The avian influenza A virus H7N9 causes severe human infections with more than 30% fatality despite the use of neuraminidase inhibitors. Currently there is no H7N9-specific prevention or treatment for humans. From a 2013 H7N9 convalescent case occurred in Hong Kong, we isolated four H7 hemagglutinin (HA)-reactive monoclonal antibodies (
Xueling Wu, Manxue Jia, HanJun Zhao, Nicholas Morano, Hong Lu, Yin-Ming Lui, Haijuan Du, Jordan Becker, Kwok-Yung Yuen, David Ho, Peter Kwong, Lawrence Shapiro, Kelvin Kai-Wang To   +12 more
openaire   +2 more sources

Avian-Origin Influenza A(H7N9) Infection in Influenza A(H7N9)–Affected Areas of China: A Serological Study [PDF]

The Journal of Infectious Diseases, 2013
Serological surveillance conducted in areas of an outbreak of influenza A(H7N9) infection in China found no seropositivity for antibodies specific for avian-origin influenza A(H7N9) among 1129 individuals of the general population, whereas >6% of 396 poultry workers were positive (on the basis of a hemagglutination inhibition titer of ≥ 80) for this ...
Chen, Y, Yang, SG, Cui, DW, Yao, HP, Lou, JZ, Huo, ZX, Xie, GL, Yu, F, Zheng, SF, Yang, YD, Zhu, YX, Lu, XQ, Liu, XL, Lau, SY, Chan, JFW, To, KKW, Yuen, KY, Chen, H, Li, LJ   +18 more
openaire   +4 more sources

Transcriptome Differences in Normal Human Bronchial Epithelial Cells in Response to Influenza A pdmH1N1 or H7N9 Virus Infection

Cells, 2022
Avian influenza A (H7N9) virus infections frequently lead to acute respiratory distress syndrome and death in humans. The emergence of H7N9 virus infections is a serious public health threat.
Tzu-Hsuan Hsieh, Ya-Jhu Lin, Mei-Jen Hsioa, Hsin-Ju Wang, Lu-Ting Chen, Shu-Li Yang, Chung-Guei Huang   +6 more
doaj   +1 more source

Influenza H7N9 and H9N2 Viruses: Coexistence in Poultry Linked to Human H7N9 Infection and Genome Characteristics [PDF]

Journal of Virology, 2014
ABSTRACT Avian influenza virus A of the novel H7N9 reassortant subtype was recently found to cause severe human respiratory infections in China. Live poultry markets were suspected locations of the human H7N9 infection sources, based on the cases' exposure histories and sequence similarities between viral isolates. To explore the
Yu, Xinfen, Jin, Tao, Cui, Yujun, Pu, Xiaoying, Li, Jun, Xu, Jin, Liu, Guang, Jia, Huijue, Liu, Dan, Song, Shili, Yu, Yang, Xie, Li, Huang, Renjie, Ding, Hua, Kou, Yu, Zhou, Yinyan, Wang, Yayu, Xu, Xun, Yin, Ye, Wang, Jian, Guo, Chenyi, Yang, Xianwei, Hu, Liangping, Wu, Xiaopeng, Wang, Hailong, Liu, Jun, Zhao, Guoqiu, Zhou, Jiyong, Pan, Jingcao, Gao, George F., Yang, Ruifu, Wang, Jun   +31 more
openaire   +3 more sources

Toward Predicting Pandemic Potential: A Comparative Analysis of Virus‐Host Interactions Between Diverse Influenza A Viruses and the Human Innate Immune System

PROTEOMICS, EarlyView.
ABSTRACT Zoonotic infections caused by influenza A viruses (IAVs) of animal origin are a major public health concern, as they may represent the initial step toward the emergence of a pandemic strain. The host range of IAVs is shaped by species‐specific virus‐host interactions, and several host barriers have been identified that restrict the adaptation ...
Antoine Gerodez, Melanie Dos Santos, Mikaël Attia, Killian De Geest, Ibrahim Hamid, Rodrigue Tesse, Ilham Fdillate, Marc Boschmans, Steven Van Borm, Mieke Steensels, Benedicte Lambrecht, Lionel Tafforeau, Caroline Demeret, Cyril Barbezange   +13 more
wiley   +1 more source

Efficacy of a parainfluenza virus 5 (PIV5)-based H7N9 vaccine in mice and guinea pigs: antibody titer towards HA was not a good indicator for protection.

PLoS ONE, 2015
H7N9 has caused fatal infections in humans. A safe and effective vaccine is the best way to prevent large-scale outbreaks in the human population. Parainfluenza virus 5 (PIV5), an avirulent paramyxovirus, is a promising vaccine vector.
Zhuo Li, Jon D Gabbard, Scott Johnson, Daniel Dlugolenski, Shannon Phan, S Mark Tompkins, Biao He   +6 more
doaj   +1 more source

Two‐Dimensional Materials For Lateral Flow Assays: A Critical Review of Functional Roles and Translational Challenges

VIEW, EarlyView.
2D nanosheets, with large surface area, excellent optical/electrical properties, and high specificity, combine with lateral flow assay strips to enable rapid, readable detection, boosting the strips’ development and applications. Abstract Lateral flow assays (LFAs) are widely used for point‐of‐care diagnostics, but their detection capability remains ...
Weimin Xu, Ruping Liu, Na Gao, Jianxiao Zhu, Haowen Jiang, Shouzheng Jiao, Zhicheng Sun, Kai Shen, Gaolian Xu, Minghua Du, Ziyan Li, Yang Wang   +11 more
wiley   +1 more source

Avian Influenza A (H7N9) and related Internet search query data in China

, 2019
The use of Internet-based systems for infectious disease surveillance has been increasingly explored in recent years. However, few studies have used Internet search query or social media data to monitor spatial and temporal trends of avian influenza in ...
Wang, Xuanzhuo, Lu, Jiahai, Chen, Ying, Hu, Wenbiao, Zhang, Yuzhou, Xu, Zhiwei   +5 more
core   +1 more source

Molecular Docking of Potential Inhibitors for Influenza H7N9 [PDF]

Computational and Mathematical Methods in Medicine, 2015
As a new strain of virus emerged in 2013, avian influenza A (H7N9) virus is a threat to the public health, due to its high lethality and pathogenicity. Furthermore, H7N9 has already generated various mutations such as neuraminidase R294K mutation which could make the anti-influenza oseltamivir less effective or ineffective. In this regard, it is urgent
Liu, Zekun, Zhao, Junpeng, Li, Weichen, Wang, Xinkun, Xu, Jingxuan, Xie, Jin, Tao, Ke, Shen, Li, Zhang, Ran   +8 more
openaire   +3 more sources