Results 61 to 70 of about 13,281 (220)

Solving the mystery of H7N9 by crystal balls [PDF]

Cell Research, 2013
How the novel influenza H7N9 virus crossed species barrier from avian to human is intriguing. Extrapolation from previous studies on H5N1 can be misleading as illustrated by crystallographic studies on the H7 hemagglutinin with G226L substitution; crystal structure of the neuraminidase N9 showed that R294K substitution interferes with binding to sialic
openaire   +2 more sources

CD4+ T‐cell responses directed towards A/H5N1‐derived haemagglutinin peptides increase in patients with seasonal influenza A virus infection

Clinical &Translational Immunology, Volume 15, Issue 8, 2026.
Abstract Objectives Recent outbreak of influenza A/H5N1 viral infections in birds and mammals worldwide prompted renewed concerns over an emerging H5N1‐related influenza pandemic in the generally immunologically‐naive global population. Cross‐reactive CD4+ T cells between A/H1N1 and A/H5N1 subtypes targeting internal and surface influenza proteins have
Lilith F Allen, Louise C Rowntree, Mitchell Jenzen, Ruth R Hagen, Nathan P Croft, Fiona James, Genevieve E Martin, Anthony W Purcell, Patricia T Illing, Steven Y C Tong, Allen C Cheng, Tom C Kotsimbos, Jason A Trubiano, Katherine Kedzierska, Thi H O Nguyen   +14 more
wiley   +1 more source

Characteristics of H7N9 cases.

, 2016
Characteristics of H7N9 cases.
Eric H. Y. Lau (160733), Juan Yang (384075), Hongjie Yu (16137), Hui Jiang (102809), Benjamin J. Cowling (91306), Luzhao Feng (376868), Ying Qin (730676), J. S. Malik Peiris (61040), Jiandong Zheng (1889047), Zhibin Peng (230975), Vicky J. Fang (91309), Peng Wu (210686), Victor Virlogeux (1889053), Tim K. Tsang (1889050)   +13 more
core   +1 more source

Intradermal delivery of a fractional dose of influenza H7N9 split vaccine elicits protective immunity in mice and rats

Human Vaccines & Immunotherapeutics, 2018
Vaccination is the most effective method of preventing the spread of the influenza virus. However, the traditional intramuscular (IM) immunization causes fear, pain, and cross infection.
Shanshan Zhou, Tianyu Ren, Hongjing Gu, Cheng Wang, Min Li, Zhongpeng Zhao, Li Xing, Liangyan Zhang, Yi Sun, Penghui Yang, Xiliang Wang   +10 more
doaj   +1 more source

Counteracting Influenza Virus Evolution Through the Full Spectrum of Broadly Protective Antibodies

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Despite the presence of licensed vaccines and therapeutics, influenza viruses remain a major public health concern, as they cause seasonal respiratory infections and pose a pandemic threat through the emergence of zoonotic strains. Although neutralizing antibodies elicited by seasonal vaccination constitute a primary defense against infection,
Yu Adachi, Yoshimasa Takahashi
wiley   +1 more source

Transcriptomic Characterization of the Novel Avian-Origin Influenza A (H7N9) Virus: Specific Host Response and Responses Intermediate between Avian (H5N1 and H7N7) and Human (H3N2) Viruses and Implications for Treatment Options

mBio, 2014
A novel avian-origin H7N9 influenza A virus (IAV) emerged in China in 2013, causing mild to lethal human respiratory infections. H7N9 originated with multiple reassortment events between avian viruses and carries genetic markers of human adaptation ...
Laurence Josset, Hui Zeng, Sara M. Kelly, Terrence M. Tumpey, Michael G. Katze   +4 more
doaj   +1 more source

Comparison of H7N9 and H9N2 influenza infections in mouse model unravels the importance of early innate immune response in host protection

Frontiers in Cellular and Infection Microbiology, 2022
The outcome of infection with influenza A virus is determined by a complex virus-host interaction. A new H7N9 virus of avian origin crossed the species barrier to infect humans, causing high mortality and emerged as a potential pandemic threat.
Cuisong Zhu, Cuisong Zhu, Miaomiao Zhang, Weihui Fu, Yongquan He, Yu Yang, Linxia Zhang, Songhua Yuan, Lang Jiang, Jianqing Xu, Jianqing Xu, Xiaoyan Zhang, Xiaoyan Zhang   +12 more
doaj   +1 more source

Exosome‐Mediated Delivery of PROTACs for Targeted Protein Degradation in Cancer, Neurodegenerative, Infectious, and Inflammatory Diseases

Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are heterobifunctional molecules that hijack the ubiquitin‐proteasome system to drive catalytic, sub‐stoichiometric degradation of disease‐associated proteins, offering a mechanistic advantage over occupancy‐driven inhibitors and access to ‘undruggable’ targets.
Sruti Bagchi Ghosh, Rumpa Banerjee, Hailah M. Almohaimeed, Amany I. Almars, Tahani Ahmad ALMatrafi, Fayez M. Saleh, Zuhair M. Mohammedsaleh, Kranti Kiran Reddy Ealla, Ajoy Kumer, Bikram Dhara   +9 more
wiley   +1 more source

H7N9 influenza and its impact on pregnancy

, 2014
This short article specifically focuses on the new emerging H7N9 influenza which has just been observed since early 2013. As a new disease, it is lack for the knowledge on the new H7N9 influenza.
Viroj Wiwanitkit
core   +1 more source

Antibody Immunity Induced by H7N9 Avian Influenza Vaccines: Evaluation Criteria, Affecting Factors, and Implications for Rational Vaccine Design

Frontiers in Microbiology, 2017
Severe H7N9 avian influenza virus (AIV) infections in humans have public health authorities around the world on high alert for the potential development of a human influenza pandemic. Currently, the newly-emerged highly pathogenic avian influenza A (H7N9)
Zenglei Hu, Zenglei Hu, Xinan Jiao, Xinan Jiao, Xinan Jiao, Xinan Jiao, Xiufan Liu, Xiufan Liu, Xiufan Liu, Xiufan Liu   +9 more
doaj   +1 more source