Results 51 to 60 of about 114,208,131 (218)

Targets of influenza human T-cell response are mostly conserved in H5N1

mBio
Frequent recent spillovers of subtype H5N1 clade 2.3.4.4b highly pathogenic avian influenza (HPAI) virus into poultry and mammals, especially dairy cattle, including several human cases, increased concerns over a possible future pandemic.
John Sidney, A-Reum Kim, Rory D. de Vries, Bjoern Peters, Philip S. Meade, Florian Krammer, Alba Grifoni, Alessandro Sette   +7 more
doaj   +1 more source

Toward Predicting Pandemic Potential: A Comparative Analysis of Virus‐Host Interactions Between Diverse Influenza A Viruses and the Human Innate Immune System

PROTEOMICS, EarlyView.
ABSTRACT Zoonotic infections caused by influenza A viruses (IAVs) of animal origin are a major public health concern, as they may represent the initial step toward the emergence of a pandemic strain. The host range of IAVs is shaped by species‐specific virus‐host interactions, and several host barriers have been identified that restrict the adaptation ...
Antoine Gerodez, Melanie Dos Santos, Mikaël Attia, Killian De Geest, Ibrahim Hamid, Rodrigue Tesse, Ilham Fdillate, Marc Boschmans, Steven Van Borm, Mieke Steensels, Benedicte Lambrecht, Lionel Tafforeau, Caroline Demeret, Cyril Barbezange   +13 more
wiley   +1 more source

Predicting Hotspots for Influenza Virus Reassortment

Emerging Infectious Diseases, 2013
The 1957 and 1968 influenza pandemics, each of which killed ≈1 million persons, arose through reassortment events. Influenza virus in humans and domestic animals could reassort and cause another pandemic.
Trevon L. Fuller, Marius Gilbert, Vincent Martin, Julien Cappelle, Parviez Hosseini, Kevin Y. Njabo, Soad Abdel Aziz, Xiangming Xiao, Peter Daszak, Thomas B. Smith   +9 more
doaj   +1 more source

Environmental factors influencing the spread of the highly pathogenic avian influenza H5N1 virus in wild birds in Europe [PDF]

, 2010
A large number of occurrences of the highly pathogenic avian influenza (HPAI) H5N1 virus in wild birds were reported in Europe. The relationship between the occurrence pattern and environmental factors has, however, not yet been explored.
Si, Y., Wang, T., Skidmore, A.K., Boer, W.F., de, Li, L., Prins, H.H.T.   +5 more
core  

Antigenic drift in H5N1 avian influenza virus in poultry is driven by mutations in major antigenic sites of the hemagglutinin molecule analogous to those for human influenza virus [PDF]

, 2011
H5N1 highly pathogenic avian influenza virus has been endemic in poultry in Egypt since 2008, notwithstanding the implementation of mass vaccination and culling of infected birds.
Arafa, Abdel, Temperton, Nigel J., Giovanni Cattoli, Alessandra Buratin, Mona Meherez Aly, Adelaide Milani, Cattoli, Giovanni, Milani, Adelaide, Zecchin, Bianca, Ilaria Capua, Capua, Ilaria, Eleonora Molesti, Bianca Zecchin, Abdel Arafa, Buratin, Alessandra, Aly, Mona Meherez, Temperton, Nigel, Meherez Aly, Mona, Nigel Temperton, Molesti, Eleonora   +19 more
core   +1 more source

Counting cases, conserving species: addressing highly pathogenic avian influenza in wildlife

Biological Reviews, Volume 101, Issue 5, Page 2190-2213, October 2026.
ABSTRACT Highly pathogenic avian influenza (HPAI) has become a critical threat to wildlife, shifting from a seasonal epizootic to a persistent, year‐round panzootic with global consequences. Here, we summarise the origin, evolutionary mechanisms, and expanding host range of the current H5N1 virus (clade 2.3.4.4b) and assess its impact on wildlife. Over
Ulrich Knief, Sandra Bouwhuis, Anja Globig, Anne Günther, Wouter Courtens   +4 more
wiley   +1 more source

Engineering Antibodies into Targeted Chimeras: From Recognition Modules to Programmable Degraders

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Antibody can be engineered into diverse lysosome‐targeting chimeras that convert target recognition into active degradation. By coupling antibody binding with recruited receptors, encoded domains, conjugated ligands, or nanoparticle scaffolds, these antibody‐associated targeted chimeras (AbTACs) platforms direct extracellular and membrane proteins ...
Kaige Chen, Quanyin Hu
wiley   +1 more source

Migratory status is not related to the susceptibility to HPAIV H5N1 in an insectivorous passerine species [PDF]

, 2009
Migratory birds have evolved elaborate physiological adaptations to travelling, the implications for their susceptibility to avian influenza are however unknown.
Helm, Barbara, Barbara Helm, Beer Martin, Teifke, J.P., Teifke, Jens Peter, Teifke, J., Angele Breithaupt, Martin Beer, Breithaupt Angele, Beer, M., Kalthoff Donata, Teifke Jens P., Helm Barbara, Helm, B., Beer, Martin, Jens P Teifke, Kalthoff, Donata, Breithaupt, Angele, Kalthoff, D., Breithaupt, A., Donata Kalthoff   +20 more
core   +2 more sources

Feathers and flu: identifying data gaps in avian influenza host dynamics to prioritize wildlife conservation Plumas y gripe: identificación de datos faltantes en la dinámica de hospedadores de la influenza aviar para priorizar la conservación de la vida silvestre

Wildlife Monographs, Volume 225, Issue 1, September 2026.
We describe the host response continuum for highly pathogenic avian influenza viruses (HPAIV), including the continuum of host responses to HPAIV infection and exposure based on the primary axis of host competence, ability to infect other hosts, and host vulnerability.
Johanna A. Harvey, Matthew Gonnerman, Shenglai Yin, Cody M. Kent, Joshua Cullen, Jeffery D. Sullivan, Jonathan B. Dain, Nichola J. Hill, Diann J. Prosser, Jennifer M. Mullinax   +9 more
wiley   +1 more source

Timing of Influenza A(H5N1) in Poultry and Humans and Seasonal Influenza Activity Worldwide, 2004–2013

Emerging Infectious Diseases, 2015
Co-circulation of influenza A(H5N1) and seasonal influenza viruses among humans and animals could lead to co-infections, reassortment, and emergence of novel viruses with pandemic potential. We assessed the timing of subtype H5N1 outbreaks among poultry,
Lizette O. Durand, Patrick Glew, Diane Gross, Matthew R. Kasper, Susan C. Trock, Inkyu K. Kim, Joseph S. Bresee, Ruben O. Donis, Timothy M. Uyeki, Marc-Alain Widdowson, Eduardo Azziz-Baumgartner   +10 more
doaj   +1 more source