Results 71 to 80 of about 620,463 (308)

Influenza A and B in a cohort of outpatient children and adolescent with influenza like-illness during two consecutive influenza seasons

Brazilian Journal of Infectious Diseases, 2020
Introduction: Influenza is an important cause of morbimortality worldwide. Although people at the extremes of age have a greater risk of complications, influenza has been more frequently investigated in the elderly than in children, and inpatients than ...
Clarisse M. Machado, Ana Carolina Mamana Fernandes de Souza, Camila Malta Romano, Wilton dos Santos Freire, Ângela Aparecida Costa, Walter Manso Figueiredo, Cláudio S. Pannuti, Expedito J.A. Luna   +7 more
doaj   +1 more source

RIG-I signaling Is essential for influenza B virus-induced rapid interferon gene expression [PDF]

, 2015
Influenza B virus causes annual epidemics and, along with influenza A virus, accounts for substantial disease and economic burden throughout the world.
Diamond, Michael S, Gale, Michael, Jr., Julkunen, Ilkka, Latvala, Sinikka, Makela, Sanna M, Osterlund, Pamela, Westenius, Veera   +6 more
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Circulation of influenza A and B in the Czech Republic from 2000-2001 to 2015-2016

BMC Infectious Diseases, 2019
Background To improve national influenza vaccination recommendations, additional data on influenza A and B virus circulation are needed. Here, we describe the circulation of influenza A and B in the Czech Republic during 16 seasons.
Martina Havlickova, Sophie Druelles, Helena Jirincova, Radomira Limberkova, Alexander Nagy, Anvar Rasuli, Jan Kyncl   +6 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Molecular epidemiology of influenza B virus among hospitalized pediatric patients in Northern Italy during the 2015-16 season.

PLoS ONE, 2017
BackgroundThe influenza B viruses belong to two lineages distinguished by their genetic and antigenic characteristics, which are referred to as the Yamagata and Victoria lineages, designated after their original isolates, B/Yamagata/16/88 and B/Victoria ...
Antonio Piralla, Giovanna Lunghi, Luca Ruggiero, Alessia Girello, Sonia Bianchini, Francesca Rovida, Silvia Caimmi, Gian Luigi Marseglia, Nicola Principi, Fausto Baldanti, Susanna Esposito   +10 more
doaj   +1 more source

Surveillance and vaccine effectiveness of an influenza epidemic predominated by vaccine-mismatched influenza B/Yamagata-lineage viruses in Taiwan, 2011-12 season.

PLoS ONE, 2013
IntroductionThe 2011-12 trivalent influenza vaccine contains a strain of influenza B/Victoria-lineage viruses. Despite free provision of influenza vaccine among target populations, an epidemic predominated by influenza B/Yamagata-lineage viruses occurred
Yi-Chun Lo, Jen-Hsiang Chuang, Hung-Wei Kuo, Wan-Ting Huang, Yu-Fen Hsu, Ming-Tsan Liu, Chang-Hsun Chen, Hui-Hsun Huang, Chi-Hsi Chang, Jih-Haw Chou, Feng-Yee Chang, Tzou-Yien Lin, Wen-Ta Chiu   +12 more
doaj   +1 more source

Antiviral resistance: influenza B [PDF]

, 2013
Currently circulating influenza viruses are resistant to adamantanes and except for a low number of sporadic cases most are sensitive to neuraminidase inhibitors (NI).
Conde, Patrícia, Cristóvão, Paula, Guiomar, Raquel, Pechirra, Pedro   +3 more
core  

Impact of ageing and a synbiotic on the immune response to seasonal influenza vaccination; a randomised controlled trial [PDF]

, 2017
Background & Aims Ageing increases risk of respiratory infections and impairs the response to influenza vaccination. Pre- and probiotics offer an opportunity to modulate anti-viral defenses and the response to vaccination via alteration of the gut ...
Agnieszka Przemska-Kosicka, Brisslert, Bunout, Caroline E. Childs, Catherine Maidens, Czesnikiewicz-Guzik, Davidson, Derhovanessian, Fagnoni, Frasca, Haynes, Haynes, Honglin Dong, Hudon, Kieran Tuohy, Lambert, Ligthart, Lomax, Lorenza Conterno, Maidens, Margot Gosney, McElhaney, Nordin, Olivares, Parveen Yaqoob, Pinna, Przemska-Kosicka, Sarbini, Scholz, Silvi, Sumia Enani, Susan Todd, Thompson, Waldmann, Wang, Wang, Weiskopf, You   +37 more
core   +4 more sources