Results 81 to 90 of about 243,088 (257)

Rationale for vaccination with trivalent or quadrivalent live attenuated influenza vaccines: Protective vaccine efficacy in the ferret model.

PLoS ONE, 2018
Background and aimThe majority of seasonal influenza vaccines are trivalent, containing two A virus strains (H1N1 and H3N2) and one B virus strain. The co-circulation of two distinct lineages of B viruses can lead to mismatch between the influenza B ...
Larisa Rudenko, Irina Kiseleva, Elena Krutikova, Ekaterina Stepanova, Andrey Rekstin, Svetlana Donina, Maria Pisareva, Elena Grigorieva, Kirill Kryshen, Arman Muzhikyan, Marina Makarova, Erin Grace Sparrow, Guido Torelli, Marie-Paule Kieny   +13 more
doaj   +1 more source

siRNA Delivery via Cross‐Linked Gelatin Microparticles Enables Targeted Modulation of Osteogenic‐Vascular Cross‐Talk: An Advanced Human 3D in Vitro Test System for Therapeutic siRNA

Advanced Healthcare Materials, EarlyView.
Osteogenic‐angiogenic cross‐talk is a vital prerequisite for vascularized bone regeneration. In this study, we investigated the effects of siRNA‐mediated silencing of two inhibitory proteins, Chordin and WWP‐1, via CaP‐NP‐loaded gelatin microparticles in osteogenically differentiated microtissues.
Franziska Mitrach, Jonas Kubat, Stefan Simm, Alexandra H. Springwald, Burak Demir, Anton Liebezeit, Michael C. Hacker, Michaela Schulz‐Siegmund   +7 more
wiley   +1 more source

Engineered ETS1‐Nanoconjugate Restores Immune Homeostasis through Dual Immune‐Vascular Modulation in Relapsing and Progressive Multiple Sclerosis

Advanced Healthcare Materials, EarlyView.
The biomimetic nanoplatform IMNP (ETS1 pDNA/PBAE@ITP‐MM) undergoes targeted disassembly at inflammatory vascular sites to release the ETS1 plasmid (pETS1). This release initiates a cascade of effects that inhibit pathogenic pathways and support immune homeostasis. (Abbreviations: EndMT, endothelial‐to‐mesenchymal transition; EC, endothelial cell; TC, T
Feng Zhang, Si‐Bo Yang, Yan Luo, Xiao‐Di Sun, Bo‐Hao Chang, Da‐Qiang Zhou, Jun‐Jie Jiang, Ya‐Nan Li, Jie‐Hong Wu, Hui‐Juan Jin, Hang Yang, Hang Hu, Yi‐Fan Zhou, Bo Hu   +13 more
wiley   +1 more source

Engineering Resatorvid‐Loaded Sub‐Microgels of Epigallocatechin‐3‐gallate/Hyaluronic Acid to Treat Acute Lung Injury

Advanced Healthcare Materials, EarlyView.
This study presents HAEP@Res sub‐microgels as a lung‐targeted delivery system integrating antioxidant activity with anti‐inflammatory therapy. The sub‐microgels demonstrate excellent biocompatibility, efficiently scavenge intracellular ROS, and downregulate pro‐inflammatory cytokines and genes in a Bleo‐induced ALI mouse model. These findings highlight
Bo Liu, Olawale Alimi Alimi, Benjamin Stearnes, Svetlana Romanova, Brady J. Sillman, Mena Asha Krishnan, Kristina Bailey, Benson J. Edagwa, Huanhuan Joyce Chen, Han‐jun Wang, Bin Duan   +10 more
wiley   +1 more source

Molecular Epidemiology and Antigenic Characterization of Seasonal Influenza Viruses Circulating in Nepal

Journal of Nepal Health Research Council, 2017
Background: Influenza is one of the public health burdens in Nepal and its epidemiology is not clearly understood. The objective of this study was to explore the molecular epidemiology and the antigenic characteristics of the circulating influenza ...
Bishnu Prasad Upadhyay, Prakash Ghimire, Masato Tashiro, Megha Raj Banjara   +3 more
doaj   +1 more source

Plant‐Produced Viral Nanoparticles Decorated with Nanobodies Against HER2 Improve Retention and Recruitment of Immune Cells in Solid Tumors

Advanced Healthcare Materials, EarlyView.
Potato virus X is a filamentous RNA plant virus that can be engineered into a molecular tool for cancer therapy. We produced genetically‐encoded virus‐derived nanoparticles decorated with nanobodies targeting cancer cell receptors, epidermal growth factor receptor (EGFR) and human epidermal growth factor 2 (HER2).
Enrique Lozano‐Sanchez, Miguel A. Moreno‐Gonzalez, Fernando Merwaiss, Nicole F. Steinmetz, José‐Antonio Daròs   +4 more
wiley   +1 more source

Recovery of an antiviral antibody response following attrition caused by unrelated infection.

PLoS Pathogens, 2014
The homeostatic mechanisms that regulate the maintenance of immunological memory to the multiple pathogen encounters over time are unknown. We found that a single malaria episode caused significant dysregulation of pre-established Influenza A virus ...
Dorothy H L Ng, John J Skehel, George Kassiotis, Jean Langhorne   +3 more
doaj   +1 more source

Self‐Assembled Inorganic Nanomembrane Tubes: Rolled‐Up Piezoelectrics for Microacoustic Wave‐Based Actuators and Sensors

Advanced Materials, EarlyView.
This study demonstrates a self‐assembly process to generate free‐standing piezoelectric nanomembranes, forming ultracompact microtubular acoustic wave sensors and actuators. The miniaturized 3D piezoelectric platform reported in this work can be applied in telecommunication, energy harvesting, and acoustofluidics. Moreover, the 3D self‐assembly can add
Raphaël C. L‐M. Doineau, Christian N. Saggau, Stefan Baunack, Thomas Gemming, Yara Abdelaal, Robert Weser, Oliver G. Schmidt, Hagen Schmidt, Andreas Winkler, Mariana Medina‐Sánchez   +9 more
wiley   +1 more source

Poking Pluripotency: Nanoinjection Into Human iPSCs

Advanced Materials, EarlyView.
Nanoinjection into hiPSCs: silicon nanotubes effectively transfect human induced pluripotent stem cells (hiPSCs) with mRNA, enabled by a delayed extracellular matrix application and enhanced surface functionalization. Nanoinjection is demonstrated with several reporter mRNA, including co‐transfection of mCherry and GFP.
Jann Harberts, Vuong Thi Thanh Xuan Ho, Yuqi Yang, Yuan Jiang, Roey Elnathan, Nicolas H. Voelcker   +5 more
wiley   +1 more source

Surface‐Capped Protein Nanoparticles for Nonviral Gene Delivery

Advanced Materials, EarlyView.
ABSTRACT Developing simple, safe, and efficient nonviral delivery systems remains a significant challenge in bioengineering. Nanoparticles offer promising gene delivery capabilities with reduced toxicity; however, long‐standing challenges related to effective plasmid encapsulation and delivery exist.
Fjorela Xhyliu, Yao Yao, Yeongun Ko, Grant Grasman, Jeffery E. Raymond, Albert Chang, Yuxuan Deng, Grant Dominic, Michael Triebwasser, Joerg Lahann   +9 more
wiley   +1 more source