Results 61 to 70 of about 14,095,140 (255)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Swine influenza A virus subtype H1N2 in Sweden [PDF]

, 2012
The influenza A virus subtypes H1N1, H1N2 and H3N2 are prevalent in pig populations worldwide. All scientific data point towards swine as the key host species when new human influenza pandemics arise.
Metreveli, Giorgi
core   +1 more source

Multivalent Epigraph Hemagglutinin Vaccine Protects against Influenza B Virus in Mice

Pathogens
Influenza B virus is a respiratory pathogen that contributes to seasonal epidemics, accounts for approximately 25% of global influenza infections, and can induce severe disease in young children.
Erika Petro-Turnquist, Brigette Corder Kampfe, Amber Gadeken, Matthew J. Pekarek, Eric A. Weaver   +4 more
doaj   +1 more source

Evolution of the neuraminidase gene of seasonal influenza A and B viruses in Thailand between 2010 and 2015.

PLoS ONE, 2017
The neuraminidase inhibitors (NAIs) oseltamivir and zanamivir are commonly used for the treatment and control of influenza A and B virus infection. However, the emergence of new influenza virus strains with reduced susceptibility to NAIs may appear with ...
Nipaporn Tewawong, Preeyaporn Vichiwattana, Sumeth Korkong, Sirapa Klinfueng, Nungruthai Suntronwong, Thanunrat Thongmee, Apiradee Theamboonlers, Sompong Vongpunsawad, Yong Poovorawan   +8 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Studies of Spanish influenza and encephalitis lethargica. [PDF]

, 2003
PhDConcomitant with the Spanish influenza and extending to the 1920s encephalitis lethargica (EL), also termed von Economo's disease or sleepy sickness, occurred in epidemic proportion.
Lo, Lily Yen-Ching
core   +2 more sources

The epidemiological signature of influenza B virus and its B/Victoria and B/Yamagata lineages in the 21st century.

PLoS ONE, 2019
We describe the epidemiological characteristics, pattern of circulation, and geographical distribution of influenza B viruses and its lineages using data from the Global Influenza B Study.
Saverio Caini, Gabriela Kusznierz, Verònica Vera Garate, Sonam Wangchuk, Binay Thapa, Francisco José de Paula Júnior, Walquiria Aparecida Ferreira de Almeida, Richard Njouom, Rodrigo A Fasce, Patricia Bustos, Luzhao Feng, Zhibin Peng, Jenny Lara Araya, Alfredo Bruno, Doménica de Mora, Mónica Jeannette Barahona de Gámez, Richard Pebody, Maria Zambon, Rocio Higueros, Rudevelinda Rivera, Herman Kosasih, Maria Rita Castrucci, Antonino Bella, Hervé A Kadjo, Coulibaly Daouda, Ainash Makusheva, Olga Bessonova, Sandra S Chaves, Gideon O Emukule, Jean-Michel Heraud, Norosoa H Razanajatovo, Amal Barakat, Fatima El Falaki, Adam Meijer, Gé A Donker, Q Sue Huang, Tim Wood, Angel Balmaseda, Rakhee Palekar, Brechla Moreno Arévalo, Ana Paula Rodrigues, Raquel Guiomar, Vernon Jian Ming Lee, Li Wei Ang, Cheryl Cohen, Florette Treurnicht, Alla Mironenko, Olha Holubka, Joseph Bresee, Lynnette Brammer, Mai T Q Le, Phuong V M Hoang, Clotilde El Guerche-Séblain, John Paget, Global Influenza B Study team   +54 more
doaj   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Swine influenza A virus subtype H1N2 in Sweden [PDF]

, 2014
The influenza A virus subtypes H1N1, H1N2 and H3N2 are prevalent in pig populations worldwide. All scientific data point towards swine as the key host species for new human influenza pandemics, which have been suggested to evolve in pigs from viral genes
Metreveli, Giorgi
core   +1 more source

Design, Synthesis, and Biological Evaluation of EdAP, a 4′-Ethynyl-2′-Deoxyadenosine 5′-Monophosphate Analog, as a Potent Influenza a Inhibitor

Molecules, 2019
Influenza A viruses leading to infectious respiratory diseases cause seasonal epidemics and sometimes periodic global pandemics. Viral polymerase is an attractive target in inhibiting viral replication, and 4′-ethynyladenosine, which has been ...
Toshifumi Takeuchi, Nongluk Sriwilaijaroen, Ayako Sakuraba, Ei Hayashi, Shinji Kamisuki, Yasuo Suzuki, Hiroshi Ohrui, Fumio Sugawara   +7 more
doaj   +1 more source