Results 51 to 60 of about 14,095,140 (255)

A SINGLE – CENTER STUDY ON THE INCIDENCE OF PCR–DETECTED INFLUENZA A/B RNA IN PATIENTS WITH SEVERE ACUTE RESPIRATORY DISEASE (2015-2019) [PDF]

Biotechnologia Acta
Influenza virus infection remains the leading cause of morbidity and mortality in the autumn-winter period. Along with insights into circulating virus subtypes and seasonal trends, reliable data on the prevalence of influenza among patients with acute ...
Matsas O.Y., Vorobiova O.V., Mulkina O.I., Slobodianiuk O.M.   +3 more
doaj   +1 more source

Emergence of an Influenza B Virus with Antigenic Change [PDF]

Journal of Clinical Microbiology, 2002
ABSTRACT Influenza B virus Yamagata group strains, isolated in the 2000 to 2001 influenza epidemic season, reacted poorly to the polyclonal ferret sera prepared against strains isolated earlier. The results of genetic analysis clarified that a point mutation of the nucleotide at position 126 in the HA1 region and the corresponding one-amino ...
Naoko, Nakagawa, Souichi, Nukuzuma, Shigekazu, Haratome, Shosan, Go, Toshimasa, Nakagawa, Kozaburo, Hayashi   +5 more
openaire   +2 more sources

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cells [PDF]

, 2008
Background: The hemagglutinin (HA) glycoprotein is the principal target of protective humoral immune responses to influenza virus infections but such antibody responses only provide efficient protection against a narrow spectrum of HA antigenic variants ...
Poon Leo L. M., Carsetti Rita, Cinatl, J, Cox Freek, Guan, Yi, Ignace Lasters, Brink, Edward van den, Jongeneelen, M, ter Meulen Jan, Edward van den Brink, de Kruif John, Cinatl Jindrich, van Deventer, E, Peiris, M, Jaap Goudsmit, Carsetti, Rita, Throsby, Mark, Carsetti, R., Leo L M Poon, Cornelissen, L., Arjen Bakker, Kruijf, C.G., de, Throsby Mark, Lasters, I., Rita Carsetti, de Kruif, J, Poon, L.L.M., Freek Cox, Yi Guan, Goudsmit, J., Lisette Cornelissen, Els van Deventer, Cornelissen Lisette, Jongeneelen Mandy, Alard Philippe, Goudsmit Jaap, Guan Yi, Guan, Y, Alard, P., Brink, E., van den, Peiris Malik, Deventer, Els van, Kruif, John de, Cinatl, J., John de Kruif, Jan ter Meulen, Cornelissen, L, Cox, F, Cox, Freek, Goudsmit, J, Cox, F., Poon, LLM, Bakker, A.B.H., Jindrich Cinatl, Lasters, Ignace, Jongeneelen, M., van Deventer Els, Mandy Jongeneelen, Poon, Leo L. M., Meulen, J., van der, Bakker, Arjen, Cinatl, Jindrich, van den Brink, E, Malik Peiris, Peiris, Malik, van den Brink Edward, Deventer, W.B.E., van, Bakker, A, Bakker Arjen, Mark Throsby, Throsby, M., Lasters, I, Guan, Y., Alard, Philippe, ter Meulen, J, Carsetti, R, Philippe Alard, Cornelissen, Lisette, Goudsmit, Jaap, Jongeneelen, Mandy, Peiris, M., Throsby, M, Meulen, Jan ter, Alard, P, Lasters Ignace   +84 more
core   +1 more source

Influenza B virus evolution: diversity of biological properties through the prism of genetic variability

Инфекция и иммунитет
Although the history of the influenza virus existence goes back thousands of years, the first human influenza A virus was discovered only in 1933, when proper models and substrates for virus isolation became available; then the influenza B virus was ...
Irina V. Kiseleva, N. V. Larionova, A. I. Zheltukhina   +2 more
doaj   +1 more source

No serological evidence that harbour porpoises are additional hosts of influenza B viruses. [PDF]

PLoS ONE, 2014
Influenza A and B viruses circulate among humans causing epidemics almost annually. While various hosts for influenza A viruses exist, influenza B viruses have been detected only in humans and seals.
Rogier Bodewes, Marco W G van de Bildt, Cornelis E van Elk, Paulien E Bunskoek, David A M C van de Vijver, Saskia L Smits, Albert D M E Osterhaus, Thijs Kuiken   +7 more
doaj   +1 more source

Role of neuraminidase in the morphogenesis of influenza B virus [PDF]

Journal of Virology, 1994
When ts7, a temperature-sensitive (ts) mutant of influenza B/Kanagawa/73 virus, infected MDCK cells at the nonpermissive temperature (37.5 degrees C), infectious virus was produced at very low levels compared with the yield at the permissive temperature (32 degrees C) and hemagglutinating activity and enzymatic activity of neuraminidase (NA) were ...
F, Yamamoto-Goshima, K, Maeno, T, Morishita, M, Ueda, Y, Fujita, K, Nakajima, S, Yoshii   +6 more
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

POPULATION IMMUNITY TO INFLUENZA VIRUS A(H1N1)pdm09, A(H3N2) AND B IN THE ADULT POPULATION OF THE RUSSIAN FEDERATION LONG-TERM RESEARCH RESULTS

Инфекция и иммунитет, 2017
Analysis of changes in the population immunity level in adults for more than 20 Russian cities, collaborating with the Federal Center for Influenza, to circulating influenza viruses A(H1N1)pdm09, A(H3N2) and B in the period from 2009 to 2015 performed ...
O. S. Konshina, A. A. Sominina, E. A. Smorodintseva, K. A. Stolyarov, I. Yu. Nikonorov   +4 more
doaj   +1 more source

Identification of a PA-binding peptide with inhibitory activity against influenza A and B virus replication. [PDF]

PLoS ONE, 2009
There is an urgent need for new drugs against influenza type A and B viruses due to incomplete protection by vaccines and the emergence of resistance to current antivirals.
Kerstin Wunderlich, Daniel Mayer, Charlene Ranadheera, Anne-Sophie Holler, Benjamin Mänz, Arnold Martin, Geoffrey Chase, Werner Tegge, Ronald Frank, Ulrich Kessler, Martin Schwemmle   +10 more
doaj   +1 more source